W1991 Is Colonoscopy Screening Mandatory for Post-Ltx Recipients?

Nicolaas, Jerome Sint; Tjon, Sze W.; Metselaar, Herold J.; Kuipers, Ernst J.; Man, Robert A. de; van, M.E. Leerdam

doi:10.1016/s0016-5085(09)63549-6

Cited by 1 publication

(14 citation statements)

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“…When the exclusion criteria were applied, the final 29 studies were included for review ( Figure 1) (2,6,16,36,37,40) were of high, 15 of medium (3,35,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)) and 8 of low quality according to the DQS (38,39,(54)(55)(56)(57)(58)(59). A pretransplantation screening protocol for LTx evaluation was mentioned in 2 studies (16,37 (3,6,37,40,45,52,53). Weighted age-matched control IR for the overall IR pooled analysis: In total, for 13 studies an age at the end of follow-up was extracted (2,6,16,35,37,40,(44)(45)(46)…”

Section: Study Selectionmentioning

confidence: 99%

“…After pooling the 10 studies (Figure 4) (2,6,16,37,40,45,49,52,53) (48,65,66 (6,37). One of these two studies reported a mean age of LTx of 56 years (37).…”

Section: Risk Of Crc In Post-ltx Patients: a Meta-analysis Of Follow-mentioning

confidence: 99%

“…To be eligible, studies could be randomized controlled trials or prospective or retrospective cohort studies. Sufficient data on incidence or risk of CRC had to be provided, such as the 10-year IR, standardized incidence ratio, cases (16). When studies lacked sufficiently detailed data, attempts were made to contact the corresponding authors by formal letter and email to obtain missing information.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…Six studies (2,6,16,36,37,40) were of high, 15 of medium (3,35,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)) and 8 of low quality according to the DQS (38,39,(54)(55)(56)(57)(58)(59). A pretransplantation screening protocol for LTx evaluation was mentioned in 2 studies (16,37). In the Rotterdam center, pretransplant colon evaluation was part of the standard workup for LTx.…”

Section: Study Selectionmentioning

confidence: 99%

“…After attempts to contact all corresponding authors (n = 29) of included studies, 7 of them provided additional data for the overall cohort, non-PSC cohort and observed events, and mean follow-up (3,6,37,40,45,52,53). Weighted age-matched control IR for the overall IR pooled analysis: In total, for 13 studies an age at the end of follow-up was extracted (2,6,16,35,37,40,(44)(45)(46)49,(51)(52)(53). In 2 of 13 studies, a standard deviation for age could also be extracted, resulting in a study-specific normal distribution (35,37).…”

Section: Study Selectionmentioning

confidence: 99%

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Risk of Colorectal Carcinoma in Post-Liver Transplant Patients: A Systematic Review and Meta-analysis

Nicolaas

Jonge²,

Steyerberg

et al. 2010

American Journal of Transplantation

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Liver transplant patients (LTx) have an increased risk for developing de novo malignancies, but for colorectal cancer (CRC) this risk is less clear. We aimed to determine whether the CRC risk post-LTx was increased. A systematic search was performed in MEDLINE and Cochrane databases to identify studies published between 1986 and 2008 reporting on the risk of CRC postLTx. The outcomes were (1) CRC incidence rate (IR per 100 000 person-years (PY)) compared to a weighted age-matched control population using SEER and (2) relative risk (RR) for CRC compared to the general population. If no RR data were available, the RR was estimated using SEER. Twenty-nine studies were included. The overall post-LTx IR was 119 (95% CI 88-161) per 100 000 PY. The overall RR was 2.6 (95% CI 1.7-4.1). The non-primary sclerosing cholangitis (PSC) IR was 129 per 100 000 PY (95% CI 81-207). Compared to SEER (71 per 100 000 PY), the non-PSC RR was 1.8 (95% CI 1.1-2.9). In conclusion, the overall transplants and the subgroup non-PSC transplants have an increased CRC risk compared to the general population. However, in contrast to PSC, non-PSC transplants do not need an intensified screening strategy compared to the general population until a prospective study further defines recommendations.

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Section: Study Selectionmentioning

confidence: 99%

“…After pooling the 10 studies (Figure 4) (2,6,16,37,40,45,49,52,53) (48,65,66 (6,37). One of these two studies reported a mean age of LTx of 56 years (37).…”

Section: Risk Of Crc In Post-ltx Patients: a Meta-analysis Of Follow-mentioning

confidence: 99%

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%