W16-P-024 Effect of long-term diet and N-3 fatty acid intervention on asymmetric dimethylarginine (ADMA)

Eid, H.M.A.; Ainesen, H.; Hjerkinn, Elsa M.; Lyberg, Torstein; Ellingsen, Ingrid; Seljeflot, I.

doi:10.1016/s1567-5688(05)80420-9

Cited by 7 publications

(8 citation statements)

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“…We therefore investigated if serum levels of different n-3 PUFA modified the association between the risk of AMI and circulating ADMA. However, we observed no association between serum n-3 PUFA levels and plasma ADMA levels, which is in agreement with a recently published intervention study from Norway showing no effect of n-3 PUFA supplementation on ADMA levels in males with long-standing hyperlipidemia [15]. Although we did not detect significant interactions, the risk of AMI related to ADMA was particularly strong among patients with levels of ALA below median, whereas no association was observed among patients with higher levels.…”

Section: Discussionsupporting

confidence: 92%

“…A randomized intervention trial, among men with long-standing hyperlipidemia, revealed no differences in ADMA levels after n-3 PUFA supplementation [15]. However, a prospective study revealed lower plasma ADMA concentrations in rats treated with EPA and DHA compared with rats given olive oil [16], and ingestion of a high fat meal, in diabetes patients, has been associated with elevated plasma ADMA levels [17].…”

Section: Introductionmentioning

confidence: 99%

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Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Borgeraas

Strand

Pedersen

et al. 2012

Cardiology Research and Practice

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Background. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. A previous rat study revealed an ADMA lowering effect following treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs). We sought to examine if an association between plasma ADMA and risk of acute myocardial infarction (AMI) was modified by serum n-3 PUFA status. Methods. The cohort included 1364 patients who underwent coronary angiography for suspected coronary artery disease in 2000-2001. Fatal and nonfatal AMI events were registered until December 31, 2006. Risk associations with AMI were estimated across ADMA quartiles (linear trend) and the upper decile. Results. No association between concentration of any n-3 PUFA and ADMA was observed. Only ADMA levels in upper decile were significantly associated with AMI with a multivariate adjusted hazard ratio (HR) (95% confidence interval) versus the rest of the population of 2.11 (1.34, 3.32). The association was strengthened among patients with below median levels of α-linolenic acid (ALA) (HR 3.12 (1.64, 5.93)), but was only influenced by longer chain n-3 PUFA after additional adjustments for HbA1c, estimated glomerular filtration rate, and hypercholesterolemia. Conclusions. The association of ADMA with risk of AMI is influenced by serum n-3 PUFA and particularly ALA.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Borgeraas

Strand

Pedersen

et al. 2012

Cardiology Research and Practice

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“…They reported that although no change in ADMA was observed in the group, the decrease in the L-arginine/ADMA ratio because of aging was more suppressed than it was in the placebo group. 21 It is possible that EPA's ADMA reduction effect may have been particularly emphasized in our study, because each of the subject patients had backgrounds of cerebral infarction, many of which were accompanied by hypertension and DM. Moreover, in the study in which EPA was administered to spontaneously hypertensive rats, the reduction in the level of ADMA was greater in the EPA-administered group than it was in the group that was administered olive oil, 22 supporting the fact that EPA reduces ADMA.…”

Section: Discussionmentioning

confidence: 89%

Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study

Hagiwara

Nishiyama

Katayama

2011

Journal of Stroke and Cerebrovascular Diseases

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“…The results compare to another dietary intervention study that demonstrated no change in ADMA levels after omega-3 fatty acid supplementation (27). In that study, ADMA levels were unchanged after 3 years of supplementation, despite good measured compliance.…”

Section: Discussionmentioning

confidence: 46%

The Impact of Fiber Supplementation on ADMA Levels

King

DeLegge

2009

Nut in Clin Prac

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BACKGROUND Asymmetric dimethyl arginine (ADMA) is an emerging biomarker that has been associated with oxidative metabolism and increased cardiovascular risk. Little information is available regarding the effect of diet on ADMA. METHODS We studied 86 adults with overweight/obesity as part of a clinical trial of psyllium supplementation to determine whether 3 months of such supplementation would affect ADMA levels. There were 41 people in the intervention group who received 14 g/day of psyllium in addition to their usual diet compared to 45 controls who followed their usual diet alone. The two groups were comparable at baseline in demographic characteristics and BMI. RESULTS Baseline ADMA levels were elevated in this overweight/obese population compared to published reference values in healthy persons (.75umol/L vs. .50umol/L). The change in ADMA levels over 3 months was not different in the psyllium group compared to the control group (−.03umol/L vs. −.01umol/L, p=.73). CONCLUSIONS These findings do not support a significant effect of psyllium fiber supplementation on ADMA.

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W16-P-024 Effect of long-term diet and N-3 fatty acid intervention on asymmetric dimethylarginine (ADMA)

Cited by 7 publications

References 0 publications

Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study

The Impact of Fiber Supplementation on ADMA Levels

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