W-reactivation and W-mutagenesis of gamma-irradiated phage lambda

Бреслер, С. Е.; Kalinin, V.L.; Shelegedin, V. N.

doi:10.1016/0027-5107(78)90105-7

Cited by 30 publications

(6 citation statements)

References 22 publications

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“…Phage damage by agents other than UVirradiation also show W-reactivation, such as gamma radiation (Bresler et al 1978), nitious acid (Ono and Shimazu 1966), hydroxylamine (Vizdalova 1969), nitrogen mustard (Kerr and Hart 1972), and 5-bromouracil incorporation before UV-irradiation (Kneser et al 1965;Kerr and Hart 1972).…”

Section: *mentioning

confidence: 99%

The Role of Inducible DNA Repair in W-Reactivation and Related Phenomena

Knudson¹

1983

Progress in Molecular and Subcellular Biology

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Section: *mentioning

confidence: 99%

The Role of Inducible DNA Repair in W-Reactivation and Related Phenomena

Knudson¹

1983

Progress in Molecular and Subcellular Biology

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“…These increases are called Weigle-reactivation (W-reactivation) or Weigle-mutagenesis (W-mutagenesis) respectively (Weigle, 1953;Witkin, 1976). Not only lesions produced by UV-irradiation but also those produced by treatment of 2-phages with chemical mutagens such as nitrogen mustard, hydroxylamine or ionising radiation can be repaired by UV-induced repair processes in host cells (Kerr and Hart, 1972;Bresler et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

UV-induced reactivation and mutagenesis of?-phages after treatment with 8-Methoxypsoralen or thiopyronine and light

Yasui

Winckler

Laskowski

1981

Radiat Environ Biophys

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Lesions, which were produced on lambda-phages DNA by the photosensitization effect of 8-methoxypsoralen (8-MOP) can be repaired by UV-induced repair systems (W-reactivation) in Escherichia coli wild type host cells. By optimum induction of the repair system, about 45% of the 8-MOP lesions are repaired. The survival of lambda-phages inactivated by the photodynamic action of thiopyronine (TP) is only negligibly increased by the same UV-induced repair systems. However, the frequencies of clear plaque mutations of 8-MOP treated as well as TP treated lambda-phages increase in similar fashion if the host cells of wild type have been irradiated with UV. These results show the different capacities of induced repair systems in repairing different types of lesions. They also suggest that some types of base damages are repaired more error-prone than other DNA-lesions.

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“…The frequency of mutants among the surviving phages is also increased (Weigle, 1953;Bresler et al, 1978). The reactivation of phage lambda is dependent on functional recA % lexA +, and lig + genes of the E. coli host ceils (Defais et al, 1971;Kerr and Hart, 1972;Miura and Tomizawa, 1968;Bresler et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

“…Kerr and Hart (1973) showed that WR is not specific for UV irradiated phages: WR occurs, although less effectively, in hydroxylamine, nitrous acid, nitrogen mus-tard, and BU inactivated phages. More recently the WR of gamma-irradiated phage lambda in UV exposed cells was described (Bresler et al, 1978). In contrast to radiation inactivated phages, WR of phages inactivated by chemical agents was found with a recA strain ofE.…”

Section: Introductionmentioning

confidence: 99%

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W-reactivation of phage lambda in X-irradiated mutants ofEscherichia coli K-12

Martignoni

Haselbacher

1980

Radiat Environ Biophys

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The survival of UV irradiated phage lambda was increased on X-irradiated E. coli K-12 host cells over that on unirradiated cells. The frequency of c mutants among the surviving phages was to a similar extent increased by the X-ray exposure of the host cells as by UV light. This W-reactivation of phage lambda occurred in uvrA, polA, and recB mutants besides the wild type at about equal X-ray doses, however, at a reduced reactivation efficiency compared with the wild type. W-reactivation was undetectable in recA mutants. While maximal UV induced W-reactivation occurred 30 min after irradiation, the maximal X-ray induced reactivation was found immediately after irradiation. Chloramphenicol (100 micrograms/ml) and nitrofurantoin (50 micrograms/ml) inhibited W-reactivation of phage lambda if added before irradiation of the host cells, indicating the necessity of protein synthesis for W-reactivation.

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W-reactivation and W-mutagenesis of gamma-irradiated phage lambda

Cited by 30 publications

References 22 publications

The Role of Inducible DNA Repair in W-Reactivation and Related Phenomena

The Role of Inducible DNA Repair in W-Reactivation and Related Phenomena

UV-induced reactivation and mutagenesis of?-phages after treatment with 8-Methoxypsoralen or thiopyronine and light

W-reactivation of phage lambda in X-irradiated mutants ofEscherichia coli K-12

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