Vγ9Vδ2-T cells as antigen presenting cells for iNKT cell based cancer immunotherapy

Werter, Inge M.; Schneiders, Famke L.; Scotet, Emmanuel; Verheul, Henk M.W.; Gruijl, Tanja D. de; Vliet, Hans J. van der

doi:10.4161/21624011.2014.955343

Cited by 2 publications

(3 citation statements)

References 10 publications

(9 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Two experimental models were designed by Werter et al to eliminate cancer cells via Vγ9Vδ2 T-cell/BTN3A1, which is working as an antigen presenting cell for the invariant natural killer T-cells (iNKT) [ 163 ]. Both approaches were shown to result in the Vγ9Vδ2 T-cells that have the capacity to act as antigen presenting cells for iNKT via trogocytosis of membrane-associated antigens, which can act as APS to propagate Th1 biased anti-tumor immune responses within tumor microenvironment [ 163 ]. These models are in agreement with the previous studies, which demonstrated that the PAg-induced Vγ9Vδ2 T-cells could recognize and kill a variety of cancer cells both in vitro as well as in vivo, such as nasopharyngeal, colon, pancreatic adenocarcinomas, breast carcinoma, melanoma, as well as the large number of hematological tumors [ 155 , 164 , 165 , 166 , 167 ].…”

Section: Discussionmentioning

confidence: 99%

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Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins

et al. 2018

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Butyrophilins (BTNs) are a group of the moonlighting proteins, some members of which are secreted in milk. They constitute a large family of structurally similar type 1 transmembrane proteins from the immunoglobulin superfamily. Although the founding member of this family is related to lactation, participating in the secretion, formation and stabilization of milk fat globules, it may also have a cell surface receptor function. Generally, the BTN family members are known to modulate co-stimulatory responses, T cell selection, differentiation, and cell fate determination. Polymorphism of these genes was shown to be associated with the pathology of several human diseases. Despite their biological significance, structural information on human butyrophilins is rather limited. Based on their remarkable multifunctionality, butyrophilins seem to belong to the category of moonlighting proteins, which are known to contain intrinsically disordered protein regions (IDPRs). However, the disorder status of human BTNs was not systematically investigated as of yet. The goal of this study is to fill this gap and to evaluate peculiarities of intrinsic disorder predisposition of the members of human BTN family, and to find if they have IDPRs that can be attributed to the multifunctionality of these important proteins.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins

et al. 2018

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“…These cells play different roles in the immune response, such as cytokine production, antigen presentation, killer cell activity enhancement, and immune cell regulation ( 43 ). In contrast to αβT cells, γδT cells are not limited by APCs, which have the ability to recognize danger signals and then activate targeted cells ( 51 , 52 ). Crowley et al.…”

Section: The Roles and Functions Of γδ T Lymphocytes In Innate And Ad...mentioning

confidence: 99%

The role of γδT lymphocytes in atherosclerosis

Xu,

Chen,

Fan

et al. 2024

Front. Immunol.

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Atherosclerosis poses a significant threat to human health, impacting overall well-being and imposing substantial financial burdens. Current treatment strategies mainly focus on managing low-density lipids (LDL) and optimizing liver functions. However, it’s crucial to recognize that Atherosclerosis involves more than just lipid accumulation; it entails a complex interplay of immune responses. Research highlights the pivotal role of lipid-laden macrophages in the formation of atherosclerotic plaques. These macrophages attract lymphocytes like CD4 and CD8 to the inflamed site, potentially intensifying the inflammatory response. γδ T lymphocytes, with their diverse functions in innate and adaptive immune responses, pathogen defense, antigen presentation, and inflammation regulation, have been implicated in the early stages of Atherosclerosis. However, our understanding of the roles of γδ T cells in Atherosclerosis remains limited. This mini-review aims to shed light on the characteristics and functions of γδ T cells in Atherosclerosis. By gaining insights into the roles of γδ T cells, we may uncover a promising strategy to mitigate plaque buildup and dampen the inflammatory response, thereby opening new avenues for effectively managing this condition.

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Vγ9Vδ2-T cells as antigen presenting cells for iNKT cell based cancer immunotherapy

Cited by 2 publications

References 10 publications

Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins

Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins

The role of γδT lymphocytes in atherosclerosis

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