Využití droplet-based mikrofluidních technik při přípravě mikročástic

Abstract

Microparticles are widely used in myriad fields such as pharmaceuticals, foods, cosmetics, and other industrial fields. Compared with traditional methods for synthesizing microparticles, microfluidic techniques provide very powerful platforms for creating

Programmed pH-responsive core–shell nanoparticles for precisely targeted therapy of ulcerative colitis

“…Specifically, the pharmaceutical excipients used in this study (F127, EPO, and L100) are all FDA-approved and are generally recognized as safe. [11][12][13]26 In addition, the preparation process is not involved with any organic solvent. Thus, the CNs@EPO@L100 nanoparticles showed good biocompatibility according to the cytotoxicity experiment (Fig.…”

“…They have been widely used in the development of pharmaceutical products because of their pH responsiveness and excellent safety. [11][12][13] Notably, EPO dissolves under acidic conditions due to its tertiary amino group, while L100 dissolves at a pH higher than 6 because it contains a large number of carboxyl groups. Therefore, effective treatment of UC can be achieved by a rational design of programmed pHresponsive nanotherapeutics using EPO and L100.…”

Eudragit E100/Hesperidin 3D Printing Filaments: Preparation, Characterization, and In Vitro Release Studies

“…Emphasis is given to filament formulations based on poly(vinyl acetate) (PVA), poly(vinylpyrrolidone) (PVP), poly(ethylene glycol) (PEG), and poly(caprolactone) (PCL) (and their composites) containing drugs, intended for printing pharmaceutical solid solutions with personalized and reproducible geometries and dosages, for application in controlled drug delivery systems [9][10][11][12][13]. Regarding the research and development of alternative and functional polymers for controlled drug release, Eudragit ® E 100 (E100) can be highlighted, whose solubility depends on the pH of the medium [14]. It is a synthetic acrylic thermoplastic copolymer with good mechanical strength, and is biocompatible, biodegradable, and safe for human oral administration [15].…”

“…In addition, research over the last decade has explored the use of polymers in the form of films, ophthalmic solutions, sprays, and transdermal and vaginal implants [18][19][20]. Its importance in programmed release formulations is also justified by the fact that this polymer can increase the dissolution rate and bioavailability of poorly water-soluble drugs, while improving the physical stability of amorphous solid dispersions [14]. In this sense, the search for alternative dosage forms with E100, which are more efficient for encapsulation, transport, and controlled release of drugs in the gastrointestinal tract, is currently an open field of research in materials and pharmaceutical technology.…”