VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation

Duan, Yingjie; Peng, Zhong; Zhong, Shuzhu; Zhou, Peng; Huang, Hong; Li, Jianlong; He, Zhangxiu

doi:10.1016/j.ejphar.2023.175610

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IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis

An,

Sun,

Liu

et al. 2023

International Immunopharmacology

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IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis

An,

Sun,

Liu

et al. 2023

International Immunopharmacology

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Regulated vascular smooth muscle cell death in vascular diseases

Yin,

Zhang,

Shen

et al. 2024

Cell Proliferation

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Regulated cell death (RCD) is a complex process that involves several cell types and plays a crucial role in vascular diseases. Vascular smooth muscle cells (VSMCs) are the predominant elements of the medial layer of blood vessels, and their regulated death contributes to the pathogenesis of vascular diseases. The types of regulated VSMC death include apoptosis, necroptosis, pyroptosis, ferroptosis, parthanatos, and autophagy‐dependent cell death (ADCD). In this review, we summarize the current evidence of regulated VSMC death pathways in major vascular diseases, such as atherosclerosis, vascular calcification, aortic aneurysm and dissection, hypertension, pulmonary arterial hypertension, neointimal hyperplasia, and inherited vascular diseases. All forms of RCD constitute a single, coordinated cell death system in which one pathway can compensate for another during disease progression. Pharmacologically targeting RCD pathways has potential for slowing and reversing disease progression, but challenges remain. A better understanding of the role of regulated VSMC death in vascular diseases and the underlying mechanisms may lead to novel pharmacological developments and help clinicians address the residual cardiovascular risk in patients with cardiovascular diseases.

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