vvd Is Required for Light Adaptation of Conidiation-Specific Genes of Neurospora crassa, but Not Circadian Conidiation

Shrode, Lori Bailey; Lewis, Zachary A.; White, L.; Bell-Pedersen, Deborah; Ebbole, Daniel J.

doi:10.1006/fgbi.2001.1264

Cited by 128 publications

(117 citation statements)

References 55 publications

(82 reference statements)

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“…In Neurospora, after the initial rapid induction of lightinducible genes, the responses quickly decrease and stay at low levels (Schrott 1981;Arpaia et al 1999;Heintzen et al 2001;Schwerdtfeger and Linden 2001;Shrode et al 2001), the results of light insensitivity. Similar to the kinetics of the induction of immediate-early genes, WC proteins first become hyperphosphorylated after 15-30 min in LL, and then the levels of their phosphorylation decrease and are maintained at levels that are higher than those in DD (Talora et al 1999;Schwerdtfeger andLinden 2000, 2001;Cheng et al 2003a;He et al 2005).…”

Section: Photoadaptation In Neurosporamentioning

confidence: 99%

“…Finally, factors such as VVD can also play an important role in mediating the photoadaptive responses in Neurospora (Heintzen et al 2001;Schwerdtfeger andLinden 2001, 2003;Shrode et al 2001). VVD is a wcdependent LOV-domain containing a blue-light photoreceptor (Cheng et al 2003a;Schwerdtfeger and Linden 2003).…”

Section: Photoadaptation In Neurosporamentioning

confidence: 99%

“…In Neurospora, despite the continuous presence of light, levels of immediate light-induced genes quickly decrease to relatively low levels after 2 h in constant light (LL) (Schrott 1981;Arpaia et al 1999;Cheng et al 2001a;Schwerdtfeger and Linden 2001;Shrode et al 2001). In addition, shifting Neurospora from low-to high-intensity light can trigger a second light induction (Arpaia et al 1999;Schwerdtfeger and Linden 2001).…”

mentioning

confidence: 99%

“…At the molecular level, the mechanism for photoadaptation is not well understood in Neurospora, although VVD and protein kinase C (PKC) have been implicated in this process (Arpaia et al 1999;Heintzen et al 2001;Schwerdtfeger and Linden 2001;Shrode et al 2001;Franchi et al 2005). VVD is a small protein consisting mostly of a single LOV domain and is another blue-light photoreceptor (Cheng et al 2003a;Schwerdtfeger and Linden 2003) that acts as a repressor of light responses.…”

mentioning

confidence: 99%

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Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation

He¹,

Liu²

2005

Genes Dev.

193

239

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Section: Photoadaptation In Neurosporamentioning

confidence: 99%

Section: Photoadaptation In Neurosporamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation

He¹,

Liu²

2005

Genes Dev.

193

239

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“…VVD is a small protein that acts as a repressor of light responses by desensitization of the WCC photoreceptor system (Heintzen et al 2001;Schwerdtfeger and Linden 2001;Shrode et al 2001). It is a blue light photoreceptor (Heintzen et al 2001;Cheng et al 2003b) containing a flavin-binding LOV domain (Schwerdtfeger and Linden 2003), but its mode of action is not known.…”

Section: Signal Transduction Of Lightmentioning

confidence: 99%

Transcriptional and post-transcriptional regulation of the circadian clock of cyanobacteria and Neurospora

Brunner¹,

Schafmeier²

2006

Genes Dev.

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Circadian clocks are self-sustained oscillators modulating rhythmic transcription of large numbers of genes. Clock-controlled gene expression manifests in circadian rhythmicity of many physiological and behavioral functions. In eukaryotes, expression of core clock components is organized in a network of interconnected positive and negative feedback loops. This network is thought to constitute the pacemaker that generates circadian rhythmicity. The network of interconnected loops is embedded in a supra-net via a large number of interacting factors that affect expression and function of core clock components on transcriptional and post-transcriptional levels. In particular, phosphorylation and dephosphorylation of clock components are critical processes ensuring robust self-sustained circadian rhythmicity and entrainment of clocks to external cues. In cyanobacteria, three clock proteins have the capacity to generate a self-sustained circadian rhythm of autophosphorylation and dephosphorylation independent of transcription and translation. This phosphorylation rhythm regulates the function of these clock components, which then facilitate rhythmic gene transcription, including negative feedback on their own genes. In this article, we briefly present the mechanism of clock function in cyanobacteria. We then discuss in detail the contribution of transcriptional feedback and protein phosphorylation to various functional aspects of the circadian clock of Neurospora crassa.Circadian rhythms are found in numerous light-perceiving organisms including cyanobacteria, algae, fungi, plants, insects, and vertebrates. The rhythms are supported by cell-autonomous circadian clocks, which regulate expression of a large number of genes on the level of transcription (for review, see Transcriptional/translational feedback loops are hallmarks of circadian clocks in all organisms. In eukaryotes, expression of core clock components is organized in a complex network of interconnected positive and negative feedback loops (for review, see Dunlap and Loros 2004;Gachon et al. 2004;Hardin 2005). This network of gene expression is assumed to generate circadian rhythmicity. Elimination of key components of these interconnected loops disrupts many, if not all, rhythmic outputs, depending on the organism. Expression, subcellular localization, assembly, function, and turnover of clock components are crucial for circadian rhythmicity, and thus, the core clock is embedded in a supra-net of cellular machinery regulating various aspects of clock function. Protein phosphorylation and dephosphorylation are important regulatory mechanisms that are critical for self-sustained circadian rhythmicity and entrainment of clocks to external cues. It is unclear to what extent reversible phosphorylations are mechanistically instrumental for generation of rhythmicity in eukaryotic clocks.Recent findings have shown that clock proteins in cyanobacteria generate a self-sustained circadian rhythm of autophosphorylation and dephosphorylation, which is independent of tra...

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Neurospora Photoreceptors

Dunlap¹,

Loros²

2005

Handbook of Photosensory Receptors

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vvd Is Required for Light Adaptation of Conidiation-Specific Genes of Neurospora crassa, but Not Circadian Conidiation

Cited by 128 publications

References 55 publications

Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation

Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation

Transcriptional and post-transcriptional regulation of the circadian clock of cyanobacteria and Neurospora

Neurospora Photoreceptors

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