Vulvovaginal-gingival Lichen Planus: Association with Lichen Planopilaris and Stratified Epithelium-specific Antinuclear Antibodies

Olszewska, Małgorzata; Banka-Wrona, Agnieszka; Skrok, Anna; Rakowska, Adriana; Górska, Renata; Solomon, Lynn W.; Rudnicka, Lidia

doi:10.2340/00015555-2141

Cited by 7 publications

(10 citation statements)

References 45 publications

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“…Thus, IIF analysis alone is not conclusive for the diagnosis of CUS, while the DIF findings have been associated only with CUS and not with OLP, to date. The only exception in which SES‐ANA in vivo binding was detected is in VVG‐LP, whose clinical features, however, are different from those of CUS (Olszewska et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…To date, the presence of speckled IgG antibody deposits in the lower third of the epithelium has been described only in CUS and not in any other immunological disease, even though Chorzelski has described positive DIF findings in 4 cases without oral lesions (Chorzelski et al, ; Olszewska, Jarząbek‐Chorzelska, Kołacińska‐Strasz, Blaszczyk, & Jabłońska, ). Only in vulvovaginal‐gingival‐pilar LP (VVG‐LP), an in vivo SES‐ANA deposition was detected, also in the genital mucosa, but the disease presents with several clinical features different from those of CUS; hence, further research is required to clarify the immunological relationship between CUS and VVG‐LP (Olszewska et al, ).…”

Section: Reviewmentioning

confidence: 99%

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Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria

et al. 2019

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Chronic ulcerative stomatitis (CUS) is an immune‐mediated disorder characterized by oral erosions and ulcers usually refractory to conventional treatments. The disease often involves middle‐aged and older women with painful lesions sometimes resembling those of erosive oral lichen planus (OLP). The most affected sites are the buccal mucosa, the gingiva and the tongue, but the skin is involved in 22.5% of cases. Histopathologic features in CUS are non‐specific and indistinguishable from those of OLP, with the exception of the presence of a mixed infiltrate composed of lymphocytes and plasma cells. Direct immunofluorescence (DIF) analysis reveals the presence of stratified epithelium‐specific antinuclear antibodies (SES‐ANA) in the lower third of the epithelium. The IgG antibodies detected on DIF are directed against the ∆Np63α isoform of p63 expressed in the nuclei of the epithelial basal cells. A distinguishing feature of CUS is the low response to conventional corticosteroid therapy and the good outcome with hydroxychloroquine at the dosage of 200 mg/day or higher dosages. This paper presents a comprehensive review of CUS and is accompanied by a new case report (the 73rd case) and a proposal for updated diagnostic criteria.

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Section: Discussionmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria

et al. 2019

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“…The term “vulvovaginal‐gingival‐pilar (VVGP) syndrome” was coined by Olszewska et al . to highlight high percentage of the coexistence of lichen planopilaris . Taking into consideration the significant propensity for scarring in VVG‐LP, the development of cicatricial alopecia should not be a surprising finding.…”

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confidence: 99%

“…The first‐line treatment suggested by most of the authors is the use of topical corticosteroids or tacrolimus and, when indicated, introduction of systemic prednisolone with azathioprine or mycophenolate mofetil. Early therapy with systemic immunosuppression usually needs to be combined with surgical management of the strictures and stenosis …”

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confidence: 99%