Vulvovaginal Candidosis

Donders, Gilbert; Ruban, Katerina S.; Bellen, Gert; Grinceviciene, Sivtrigaile

doi:10.1002/9781119380924.ch15

Cited by 2 publications

(3 citation statements)

References 123 publications

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“…GSM was previously known as vulvovaginal atrophy or atrophic vaginitis (Caretto et al, 2017;Donders et al, 2019). When women reach perimenopause, ovarian function declines, resulting in lower estrogen levels.…”

Section: Effect Of Probiotics On Gsmmentioning

confidence: 99%

The role of probiotics in vaginal health

Mei¹,

2022

Front. Cell. Infect. Microbiol.

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Probiotics have been widely used in the treatment of intestinal diseases, but the effect of probiotics on female reproductive tract health is still controversial. Lactobacillus is the most abundant microorganism in the vagina, which is related to the vaginal mucosal barrier. Lactobacillus adheres to the vaginal epithelium and can competitively antagonize the colonization of pathogens. The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer. We review the research progress of probiotics represented by Lactobacillus in gynecological diseases such as human papilloma virus (HPV) infection, bacterial vaginosis (BV) and Genitourinary Syndrome of Menopause (GSM), so as to provide basis for further exerting the role of probiotics in women’s health.

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Section: Effect Of Probiotics On Gsmmentioning

confidence: 99%

The role of probiotics in vaginal health

Mei¹,

2022

Front. Cell. Infect. Microbiol.

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“…In more recent cases, miconazole was replaced with fluconazole, which is preferred when systemic treatment is required. This is because of the improved safety and predictable absorption of fluconazole when administered orally . In contrast to fluconazole, miconazole is approved for topical administration only in humans.…”

Section: Introductionmentioning

confidence: 99%

“…This is because of the improved safety and predictable absorption of fluconazole when administered orally. 25 In contrast to fluconazole, miconazole is approved for topical administration only in humans. It is used in the treatment of fungal or yeast infections of the skin or vagina and for the treatment of oropharyngeal candidiasis in patients 16 years and older.…”

Section: Introductionmentioning

confidence: 99%

Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors

Sharma,

Madia,

Tudino

et al. 2023

J. Med. Chem.

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Developing drugs for brain infection by Naegleria fowleri is an unmet medical need. We used a combination of cheminformatics, target-, and phenotypic-based drug discovery methods to identify inhibitors that target an essential N. fowleri enzyme, sterol 14-demethylase (NfCYP51). A total of 124 compounds preselected in silico were tested against N. fowleri . Nine primary hits with EC 50 ≤ 10 μM were phenotypically identified. Cocrystallization with NfCYP51 focused attention on one primary hit, miconazole-like compound 2a . The S -enantiomer of 2a produced a 1.74 Å cocrystal structure. A set of analogues was then synthesized and evaluated to confirm the superiority of the S -configuration over the R -configuration and the advantage of an ether linkage over an ester linkage. The two compounds, S - 8b and S - 9b , had an improved EC 50 and K D compared to 2a . Importantly, both were readily taken up into the brain. The brain-to-plasma distribution coefficient of S - 9b was 1.02 ± 0.12, suggesting further evaluation as a lead for primary amoebic meningoencephalitis.

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Vulvovaginal Candidosis

Cited by 2 publications

References 123 publications

The role of probiotics in vaginal health

The role of probiotics in vaginal health

Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors

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