Vulvodynia—new and more effective approaches to therapy

Bates, Christine; Timmins, D J

doi:10.1258/0956462021924802

Cited by 17 publications

(17 citation statements)

References 4 publications

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“…A total of nine articles were identified for possible inclusion in the review. The search yielded one open‐label trial ; six nonexperimental studies, i.e., one nonrandomized prospective cohort study of patients receiving sequentially applied treatment protocols including anticonvulsants , three retrospective case series , and two retrospective chart reviews ; and finally, two case reports . There were no randomized controlled trials identified.…”

Section: Resultsmentioning

confidence: 99%

“…The anticonvulsants examined in the available literature included gabapentin , pregabalin , lamotrigine , and carbamazepine . Topical gabapentin, instead of orally administered gabapentin, was the focus of one retrospective investigation .…”

Section: Resultsmentioning

confidence: 99%

“…Most of the articles reviewed here consisted of descriptive studies, retrospective chart reviews, and case reports . The proportions of patients for whom symptom relief was achieved with anticonvulsant use were the main outcomes reported; these are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of the Utility of Anticonvulsant Pharmacotherapy in the Treatment of Vulvodynia Pain

Leo

2013

The Journal of Sexual Medicine

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Introduction Anticonvulsants have increasingly been invoked in the treatment of vulvodynia. However, the evidence supporting this treatment approach has not been systematically assessed. Aim The study aims to evaluate the efficacy of anticonvulsant pharmacotherapy in the treatment of vulvodynia. Methods A comprehensive search of the available literature was conducted. Main Outcome Measure An assessment of the methodological quality of published reports addressing the utility of anticonvulsants in the treatment of vulvodynia was undertaken. Results The search yielded nine published reports, i.e., one open-label trial, six nonexperimental studies, and two case reports. A number of methodological shortcomings were identified in several of the reports with respect to study design, including small sample sizes, lack of placebo or other comparison groups, inadequate outcome measures, among others. The vast majority of studies employed gabapentin. Evidence supporting the benefit of anticonvulsants studied to date was limited, i.e., based predominantly upon descriptive/observational reports. There were no systematic investigations into the comparative efficacy of different anticonvulsant agents in the treatment of vulvodynia. Conclusion Although some vulvodynia-afflicted patients derive symptom relief from anticonvulsants, there is, as yet, insufficient evidence to support the recommendation of anticonvulsant pharmacotherapy in the treatment of vulvodynia. Additional investigations, employing randomized controlled trials, are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of the Utility of Anticonvulsant Pharmacotherapy in the Treatment of Vulvodynia Pain

Leo

2013

The Journal of Sexual Medicine

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“…26 This work has been borne out in other studies. 27 Glossodynia, a psychosomatic disorder with painful sensations in the mouth and throat, especially of the tongue, which have no definable cause, also responds to gabapentin. 28 Gabapentin is useful in treating "hot flashes" and hypothermia, and thus temperaturesensitive dermatoses.…”

Section: Skin Sensitivity Allodynia and Gabapentinmentioning

confidence: 99%

The role of gabapentin in treating diseases with cutaneous manifestations and pain

Scheinfeld

2003

Int J Dermatology

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Gabapentin is a very promising medication in the treatment of post-herpetic neuralgia and pain. Because dermatological patients suffer pain from painful tumors, after surgery, in conjunction with neuropathic ulcers, during dressing changes involving serious medical conditions, its applications seem manifold. Future studies must assess its role in the treatment of pruritus and other dermatological conditions involving pain or alteration of sensation.

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“…In some cases the dynias occur secondarily, but more often, despite an exhaustive evaluation, no etiology is found. Two case series (8,9) of vulvodynia have shown good clinical response to gabapentin.…”

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confidence: 99%

Pregabalin-Induced Remission in a 62-Year-Old Woman with a 20-Year History of Vulvodynia

Jerome

2007

Pain Research and Management

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A case of a 62-year-old woman presenting with a 20-year history of vulvodynia previously unresponsive to medical treatment is described. The epidemiology, phenomenology and medical management of vulvodynia is reviewed. The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition.

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Vulvodynia—new and more effective approaches to therapy

Cited by 17 publications

References 4 publications

A Systematic Review of the Utility of Anticonvulsant Pharmacotherapy in the Treatment of Vulvodynia Pain

A Systematic Review of the Utility of Anticonvulsant Pharmacotherapy in the Treatment of Vulvodynia Pain

The role of gabapentin in treating diseases with cutaneous manifestations and pain

Pregabalin-Induced Remission in a 62-Year-Old Woman with a 20-Year History of Vulvodynia

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