Vulvitis chronica plasmacellularis (Zoon's vulvitis)

Kavanagh, G.M.; Burton, P.; Kennedy, Cameron

doi:10.1111/j.1365-2133.1993.tb03320.x

Cited by 40 publications

(32 citation statements)

References 5 publications

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“…Vulvar chronic, well-circumscribed, glistening, glazed, single or multiple erythematous patches with a faint orange hue were the typical clinical aspects. 2,7 Multiple pinpoint brighter purpuric spots ('Cayenne pepper spots') and erosive lesions were supportive clinical features. On histological examination, the most important parameter was a percentage of plasma cells in the dermal infiltrate >50%.…”

Section: Study Patientsmentioning

confidence: 98%

Comparative study on topical immunomodulatory and anti‐inflammatory treatments for plasma cell vulvitis: long‐term efficacy and safety

Virgili

Borghi

Minghetti

et al. 2014

Acad Dermatol Venereol

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Section: Study Patientsmentioning

confidence: 98%

Comparative study on topical immunomodulatory and anti‐inflammatory treatments for plasma cell vulvitis: long‐term efficacy and safety

Virgili

Borghi

Minghetti

et al. 2014

Acad Dermatol Venereol

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“…Well-circumscribed erythematous patches on the inner surface of the labia minora and the periurethral area are the typical clinical aspects; multiple purpuric pinpoint spots and erosive lesions may also be observed [1, 2, 4, 7, 8]. …”

Section: Introductionmentioning

confidence: 99%

“…Its precise incidence is unknown [1] as well as its aetiopathogenesis, although a variety of triggering factors have been suspected [2,3,4,5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Tacrolimus 0.1% Ointment: Is It Really Effective in Plasma Cell Vulvitis?

Mantovani¹,

Lauriola²,

Marzola³

et al. 2008

Dermatology

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Background: Plasma cell vulvitis is a clinically and histologically well-characterized chronic disease that usually relapses after various topical therapies. Considering the inflammatory nature of the disease, the new topical calcineurin inhibitors have been also employed successfully in few cases of Zoon’s balanitis, the corresponding male condition. Objective: The aim of our study is to evaluate the effectiveness of tacrolimus ointment in a small group of plasma cell vulvitis sufferers. Methods: 4 women affected by biopsy-proved plasma cell vulvitis were enrolled, after informed consent. The topical drug was applied twice daily for 6 weeks, then tapered on the basis of the clinical results. Symptoms and objective parameters were obtained periodically at the beginning, after 6 weeks and up to the end of the topical treatment. A final biopsy was performed in 3 out of our 4 patients. The follow-up is still ongoing. Results: The comparative analysis of subjective, objective and histopathological data has shown discordant and less encouraging results than those reported for the corresponding male condition. Conclusion: At the moment, topical tacrolimus could be considered an alternative treatment for plasma cell vulvitis only in cases resistant to conventional therapies.

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“…The incidence of PCV is unknown, as well as its aetiopathogenesis, although a variety of triggering factors have been hypothesized [1,2,3,4,5,19]. The presence of a lichenoid infiltrate containing a predominance of plasma cells as a distinctive histological marker suggests a polyclonal stimulation of B cells [23].…”

Section: Discussionmentioning

confidence: 99%

“…All the study patients received the diagnosis at our Vulva Unit, based on both clinical and histological features. Chronic, well-circumscribed glistening, glazed, single or multiple erythematous patches with a faint orange hue affecting mainly the inner surface of the labia minora and the periurethral area but also the vestibule, the introitus, the clitoris and the fourchette were the typical clinical aspects [2,19] (fig. 1).…”

Section: Methodsmentioning

confidence: 99%

Symptoms in Plasma Cell Vulvitis: First Observational Cohort Study on Type, Frequency and Severity

Corazza

Minghetti

Borghi³

2015

Dermatology

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Background: Studies assessing symptoms of plasma cell vulvitis (PCV) are lacking. Objectives: To assess the prevalence and severity of PCV-related symptoms and identify possible associations between patient characteristics, clinical features of PCV and treatments administered before a definitive diagnosis. Methods: Thirty-six patients affected with PCV were included. Data were collected by direct interview and clinical examination. Results: Thirty patients (83.3%) complained of symptoms: burning was the most frequent (80.6%) while dyspareunia was the severest. Of the symptomatic patients, 73.3% experienced severe symptoms. Severity of symptoms was not associated with age at onset and duration of PCV. Almost 70% of the patients had previously undergone treatments. Conclusions: Symptoms in PCV are frequent and more than often severe. Neither age at onset nor duration of the disease nor the extent of vulvar involvement were associated with symptom severity. Both the delay in diagnosis and the inappropriate previous treatments seem to indicate frequent misdiagnosis.

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Vulvitis chronica plasmacellularis (Zoon's vulvitis)

Abstract: Vulvitis chronica plasmacellularis (Zoon's vulvitis) is rare. We describe a case in whom all the typical features, as delineated by Zoon, are demonstrated.

Cited by 40 publications

References 5 publications

Comparative study on topical immunomodulatory and anti‐inflammatory treatments for plasma cell vulvitis: long‐term efficacy and safety

Comparative study on topical immunomodulatory and anti‐inflammatory treatments for plasma cell vulvitis: long‐term efficacy and safety

Tacrolimus 0.1% Ointment: Is It Really Effective in Plasma Cell Vulvitis?

Symptoms in Plasma Cell Vulvitis: First Observational Cohort Study on Type, Frequency and Severity

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