Vulvar melanoma at the M. D. Anderson Cancer Center: 25 years later

Verschraegen, Claire F.; Benjapibal, Mongkol; Supakarapongkul, W.; Levy, Lawrence B.; Ross, Merrick I.; Atkinson, E. Neely; Bodurka, Diane C.; Kavanagh, John J.; Kudelka, Andrzej P.; Legha, Sewa S.

doi:10.1046/j.1525-1438.2001.01043.x

Cited by 136 publications

(97 citation statements)

References 24 publications

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“…Most frequent symptoms are bleeding, itching/burning, mass, miction disturbances, discharge, alterations in previously existing nevi, particularly increase in size and pigmentation, inguinal swelling, and pain. Most of the melanomas of the female genitalia are thick (>2 mm) at the time of diagnosis [17,35,36]. The reported 5-year survival rates range from 27 to 59% for vulvar primary tumors and from 13 to 33% for vaginal primary tumors [17,33,34,36,37].…”

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

“…Most of the melanomas of the female genitalia are thick (>2 mm) at the time of diagnosis [17,35,36]. The reported 5-year survival rates range from 27 to 59% for vulvar primary tumors and from 13 to 33% for vaginal primary tumors [17,33,34,36,37]. Meanwhile, the overall 5-year survival rate for cutaneous melanoma in Germany is reported at 81% [2].…”

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

“…Meanwhile, the overall 5-year survival rate for cutaneous melanoma in Germany is reported at 81% [2]. Sig-nificant predictors of survival of mucosal melanomas of the female genitalia are tumor thickness, clinical stage (including lymph node status), ulceration of the tumor and amelanosis [14,17,36,38]. The mainstay of therapy again is surgical excision, although much debate exists regarding the extent of resection needed to obtain local control.…”

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

“…The mainstay of therapy again is surgical excision, although much debate exists regarding the extent of resection needed to obtain local control. Up to the 1980s more radical procedures (radical vulvectomy, radical vaginectomy, bilateral inguinofemoral lymphadenectomy) were performed and recommended [33,36,37]. Since then, several groups have found no advantage of radical surgery regarding overall survival, locoregional control or distant control compared to wide local excision with clear margins, although this may be curative in thin lesions only [14,17,35,36,38,39].…”

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

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Primary Extracutaneous Malignant Melanoma: A Comprehensive Review with Emphasis on Treatment

et al. 2004

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Extracutaneous malignant melanomas (EMM) require special consideration in the field of oncology due to their rareness and – depending on the localization – the frequency of late diagnosis with consecutive poor prognosis. Only 4–5% of all primary melanomas do not arise from the skin. Most frequently they originate from the mucous membranes lining the respiratory, digestive, and genitourinary tracts or in the eyes as well as in the cerebral meninges. Extracutaneous melanomas are considered to be biologically more aggressive than cutaneous melanomas. The Clark level and Breslow index used for evaluation of cutaneous melanomas are not applicable to EMM and, at present, there are no consistent, internationally accepted therapy standards for this form of the disease. For this reason, this review focuses primarily on the literature pertaining to therapeutic strategies as well as epidemiologic, biological, and diagnostic aspects of this disease.

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Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

Section: Melanoma Of the Female Genitaliamentioning

confidence: 99%

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Primary Extracutaneous Malignant Melanoma: A Comprehensive Review with Emphasis on Treatment

et al. 2004

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“…Subsequently, four other studies including 17 cases of vulvar melanomas were published. 19,[22][23][24] The groin detection rate ranged from 83 to 100%. The sentinel lymph node procedure was introduced in our institution for cutaneous melanoma in 1998.…”

Section: Discussionmentioning

confidence: 99%

Vulvar melanoma: report on eleven cases and review of the literature

et al. 2010

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Context and objeCtive: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature.design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo.Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results:The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. ConClusions:The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method. RESUMOContexto e objetivo: Melanoma de vulva é uma doença rara. Descrevemos a experiência de uma instituição e revisamos a literatura. ConClusões: O prognóstico das pacientes com melanoma de vulva geralmente é ruim, com tendência a recorrência regional e à distância. A profundidade de invasão e envolvimento linfonodal são os principais fatores prognósticos. Na maioria dos casos a ressecção da lesão com margens adequadas pode substituir a vulvectomia. A linfadenectomia inguino-femoral eletiva ainda é o procedimento padrão para estadiamento linfonodal. Pesquisa do linfonodo sentinela é factível e deve ser realizada por equipe multidisciplinar com experiência no método.

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