Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors

Khoury, Jinane El; Renald, Marie-Hélène; Plantier, F.; Avril, Marie-Françoise; Moyal‐Barracco, Micheline

doi:10.1016/j.jaad.2016.01.034

Cited by 29 publications

(20 citation statements)

References 12 publications

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“…Concerning age, our findings are concordant with the literature age distribution, ranging from 26 to 84 years 1,5,6 …”

Section: Reportsupporting

confidence: 92%

“…2d) had nonpigmented nodules with polymorphous vessels (lacunes, elongated telangiectasias and some glomerular vessels), together with some shiny white areas. Patient 4 had a bluish nodule with an overall morphology already described elsewhere; 1 dermoscopy showed a greyish‐blue, homogeneous pigmentation, without any vascular pattern (Fig. 2b).…”

Section: Reportmentioning

confidence: 53%

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Vulval hidradenoma papilliferum: a clinical and dermoscopic study

Tosti

Salvini

Barisani

et al. 2020

Clin. Exp. Dermatol.

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Summary Hidradenoma papilliferum (HP) is a rare, slow‐growing, benign adnexal tumour with apocrine differentiation. It usually affects the anogenital region in adult women and is clinically polymorphous, mimicking other benign or malignant neoformations. The dermoscopic features of vulval HP have not been reported yet. We report the clinical and dermoscopic features in a case series of histopathologically proven vulval HPs. Dermoscopy may be a useful tool for the diagnosis of vulval HP. To our knowledge, our paper represents the first report of dermoscopic findings in a series of vulval HPs in a multiracial population.

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“…Concerning age, our findings are concordant with the literature age distribution, ranging from 26 to 84 years 1,5,6 …”

Section: Reportsupporting

confidence: 92%

Section: Reportmentioning

confidence: 53%

Vulval hidradenoma papilliferum: a clinical and dermoscopic study

Tosti

Salvini

Barisani

et al. 2020

Clin. Exp. Dermatol.

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“…Lin et al (12) discovered that CK5, CK8 and CK14 can be expressed in the sweat gland tissues, while only CK5 and CK14, instead of CK8, can be expressed in the sebaceous gland. El-Khoury et al (13) revealed that different types of CK expression levels are present in different hair structures. For instance, CK15 expression exists in the hair bulb stem cells, CK1 and CK10 expression levels are present in the inner root sheath of the hair follicle, CK14 and CK15 expression levels are detectable in the outer layer of the outer root sheath, and CK6, CK16 and CK17 expression levels exist in the inner layer of the outer root sheath, which are consistent with the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Cytokeratin expression in epidermal stem cells in skin adnexal tumors

Xiao-fang

Wang

et al. 2018

Oncol Lett

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The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. The expression levels of the seven types of CK in different kinds of skin appendages were observed and recorded. The expression levels of the seven types of CK in the 132 cases of skin adnexal tumor tissues were different. CK10 was mainly expressed in squamous cell carcinoma, but it was not expressed in basal cell carcinoma. CK19 was expressed in basal cell carcinoma, but its expression was not detected in squamous cell carcinoma. As the degree of differentiation was increased in the epidermis, hair follicle and sebaceous gland, the expressed molecular weight of CK was augmented gradually. The expression levels of five types of CK (namely, CK8, CK10, CK14, CK18 and CK19) could be measured in the squamous cell carcinoma and basal cell carcinoma. Statistical analysis revealed that there were statistically significant differences in the expression levels of these five types of CK in the two cell carcinomas (P<0.05). Five types of CK, i.e., CK7, CK8, CK17, CK18 and CK19, had markedly different expression levels in hair follicle tumor and sweat gland tumor, which were statistically significant (P<0.05). The expression levels of a group of CKs detected by virtue of semi-quantitative analysis via immunohistochemistry can be regarded as one of the important indexes for clinical diagnosis of skin adnexal tumors.

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“…HP is a benign cutaneous adnexal neoplasm, commonly arising in the vulva of adult women, mainly on the labia majora, although it has also been described in other locations of the anogenital area, including the labia minora, interlabial sulcus, clitoris, posterior fourchette, mons pubis, perineum and anal region . In a review on HP location in a large series of cases, there were no perianal examples.…”

Section: Discussionmentioning

confidence: 99%