Vulvar carcinoma in situ: A report of 28 cases

Paola, Guillermo R. di; Rueda-Leverone, Nidia Gómez; Belardi, María G.; Vighi, Susana

doi:10.1016/0090-8258(82)90096-8

Cited by 12 publications

(2 citation statements)

References 14 publications

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“…Multicentric disease has been reported in patients with VIN. [18][19][20][21] The multicentricity of VIN is age-related, decreasing from 59% in women aged 20 to 34 to 10% in patients over 50 years of age. 21 Colposcopy of the vulva (also described as vulvoscopy) with the application of 3% to 5% acetic acid is nonmandatory for the diagnosis of VIN usual type and sometimes it gives confounding results.…”

mentioning

confidence: 99%

Squamous Vulvar Intraepithelial Neoplasia

Preti¹,

Seters²,

Sideri³

et al. 2005

Clinical Obstetrics and Gynecology

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mentioning

confidence: 99%

Squamous Vulvar Intraepithelial Neoplasia

Preti¹,

Seters²,

Sideri³

et al. 2005

Clinical Obstetrics and Gynecology

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“…, 1983;zur Hausen et al, 1984;zur Hausen, 1985;Reid et al, 1984;Gissmann and Schneider, 1986). HPV-16 (Ikenberg et al, 1983;Boshart et al, 1984) and, less frequently, HPV-18 and HPV-33 are associated with cervical and vulvar pre-cancerous lesions and cervical and anogenital carcinomas (Di Paola et al, 1982;Diirst et al, 1983). However, HPV-16 is also associated with bowenoid papulosis (BP) (Diirst et al, 1983;Gross et al, 1985Gross et al, , 1986Obalek et al, 1986), a multifocal disease of external genitalia with histological features of Bowen's atypia, usually regressing spontaneously after a duration of several months or years.…”

mentioning

confidence: 99%

Abrogated NK‐cell lysis of human papillomavirus (HPV)‐16‐bearing keratinocytes in patients with pre‐cancerous and cancerous HPV‐induced anogenital lesions

Malejczyk¹,

Majewski²,

Jabłońska³

et al. 1989

Intl Journal of Cancer

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Natural-cell-mediated cytotoxicity against K-562 erythroleukemic cells and human papillomavirus (HPV)-16 harboring Sk-v keratinocytes was tested in 38 age- and sex-matched healthy volunteers and in patients with HPV-induced benign and malignant anogenital lesions: 9 persons with HPV-16-induced bowenoid papulosis (BP), 8 with anogenital carcinomas (5 with HPV-16- or 33-associated squamous-cell carcinomas of Bowen's type and 3 with HPV-6-associated Buschke-Loewenstein verrucous carcinomas) and 12 with HPV-6-induced condylomata acuminata. Both K-562 and Sk-v cells were killed by a non-adherent CD16+ subset of PBMC as revealed by cell fractionation on the basis of their adherence to plastic and by treatment with Leu-IIb monoclonal antibody (MAb) and complement. "Cold" target competitive assays demonstrated that both cell types inhibited lysis of labelled Sk-v cells. In patients with BP and anogenital carcinomas induced by HPV-16 or 33, there was a significant (at least at p less than 0.01) decrease of Sk-v cell lysis as compared with the healthy control group. Anti-K-562 activity was not affected. In patients with anogenital carcinomas the degree of Sk-v lysis was decreased in proportion to the duration of lesions (correlation coefficient-r = -0.79). Neither anti-K-562 nor anti-Sk-v cytotoxicities were significantly affected in patients with condylomata and with HPV-6 associated verrucous carcinomas. Short-term (3 hr) pre-incubation of normal PBMC with sera from patients with BP and HPV-16-associated anogenital carcinomas resulted in significant inhibition of their ability to lyse Sk-v cells. Lysis of K-562 cells remained unaffected. In patients with carcinomas, the suppressive effect of sera was associated with a lowering of the ability of their PBMC to lyse Sk-v cells (r = -0.79). In patients with longer tumor persistence, the suppressive effect of serum was proportionally higher (r = 0.86).

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Lesions of the Male and Female External Genitalia Associated with Human Papillomaviruses

Gross¹

1987

Papillomaviruses and Human Disease

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Vulvar carcinoma in situ: A report of 28 cases

Cited by 12 publications

References 14 publications

Squamous Vulvar Intraepithelial Neoplasia

Squamous Vulvar Intraepithelial Neoplasia

Abrogated NK‐cell lysis of human papillomavirus (HPV)‐16‐bearing keratinocytes in patients with pre‐cancerous and cancerous HPV‐induced anogenital lesions

Lesions of the Male and Female External Genitalia Associated with Human Papillomaviruses

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