Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre

Namuduri, R.; Lim, Timothy Yk; Yam, P.S.; Gatsinga, Rene; Lim-Tan, Soo Kim; Chew, Sung Hock; Koh, Mark Ja; Mansor, Sorsiah

doi:10.11622/smedj.2019014

Cited by 15 publications

(19 citation statements)

References 15 publications

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“…Patients who met the following criteria were included in the study: (1) confirmed histologic diagnosis of vulvar BCC, (2) underwent initial surgery in our Institution (Centre Hospitalier Intercommunal de Creteil), (3) available clinicopathologic data and medical history, and (4) available histologic slides with all histologic margins.…”

Section: Patients and Samplesmentioning

confidence: 99%

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Flipo

Bani

Rejaibi

et al. 2021

International Journal of Gynecological Pathology

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Basal cell carcinoma (BCC) is the most frequent skin cancer but <1% of the cases develop in the vulva. Histoprognostic features of vulvar BCCs are not recognized and, consequently, the treatment of the disease is not well codified. To overcome this lack of knowledge, we have performed a retrospective analysis of vulvar BBCs to assess the value of various histological features regarding the disease outcome. In all, 19 patients surgically treated for a vulvar BCC in the Centre Hospitalier Intercommunal de Créteil from March 1, 2000 to September 26, 2019 were retrieved. Clinical and histologic features were reviewed in all cases and analyzed in comparison with disease recurrence and patient's survival. The median age of the patients was 74 (range 54-99) yr. Tumor location on the labium majus was the most frequent (68%). None presented with a medical condition related to BCC. All the patients were treated by surgery alone, except one who benefited from additional radiotherapy. We found a significant association between tumor size and recurrences (P = 0.031). Other features associated with disease outcome were tumor thickness, treatment type, and surgical margins. Recurrence was observed for tumors larger than 20 mm with a surgical margin of less than 3 mm. A combination of tumor size, thickness, and surgical margin are histoprognostic factors more significant than tumor subtype.

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Section: Patients and Samplesmentioning

confidence: 99%

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Flipo

Bani

Rejaibi

et al. 2021

International Journal of Gynecological Pathology

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“…Dear Sir, I thank De Giorgi et al for their comment on our paper. (1,2) I agree that in the light of strong clinical evidence and the numerous indexed papers of the past few years, dermatoscopy should have been at least mentioned. Dermatoscopy features of vulvar basal cell carcinomas (BCCs) are well recognised, such as linear and arborising telangiectasia, pinkish background, blue ovoid nests, white shiny structures and brown dots.…”

Section: E T T E R T O T H E E D I T O Rmentioning

confidence: 88%

Authors’ reply: Comment on: Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre

Namuduri¹,

Lim²,

Yam³

et al. 2020

smedj

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“…Most BCCs are indolent, only infiltrate locally, and rarely metastasize ( 18 ). As a result of delayed visits and diagnosis, the tumor size of genital BCCs tends to be large.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the higher incidence, females had better DSS than males, and the cause remains to be elucidated. Most BCCs are indolent, only infiltrate locally, and rarely metastasize (18). As a result of delayed visits and diagnosis, the tumor size of genital BCCs tends to be large.…”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

et al. 2021

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IntroductionBasal cell carcinoma (BCC) located on the genitalia is rare; data on the clinicopathologic features and survival outcomes are only available through case reports and small case series studies.PurposeThis study aimed to explore the epidemiology and identify the prognostic factors of genital BCCs.MethodsWe queried the 18 registries of the Surveillance, Epidemiology, and End Results database for patients with primary BCCs of the genital skin from 2000 through 2017. The primary endpoint was overall survival (OS) and disease specific survival (DSS). Kaplan-Meier survival analysis was conducted to assess the impact of clinicopathological variables on OS and DSS. Multivariate Cox proportional hazards model was performed to evaluate risk factors for OS.ResultsA total of 1,607 cases of genital BCCs were identified. The cohort was composed of 1,352 women (84.1%) and 255 men (15.9%). The median (P25, P75) age of the entire cohort was 73(63–82)years. White patients accounted for 87.2% of the cases. For women and men, the most common site of involvement was the labia majora (89.6%) and scrotum (74.5%), respectively. The majority of patients with genital BCC had localized disease (75.5%). Kaplan-Meier survival analysis showed that female genital BCCs experienced better DSS than men (209.1 months vs 194.8 months); for men, BCCs located on the scrotum had better DSS and OS than those on the penis (P < 0.05 for both endpoints). All patients with distant disease died of disease-specific death, and the average survival time was 8.2 months. Multivariate analysis revealed that age, primary site, and stage were independent determinants of OS for men, while tumor size, histologic subtype, and race were not. For women, factors associated with worse OS included increasing age, tumor size more than 2 cm, and distant disease; factors associated with a decreased risk included “other” and “unknown” races.ConclusionThe prognosis of genital BCCs is excellent, while the survival of distant disease is very poor. Despite similar clinicopathologic features and overall survival outcomes, men and women should be treated as two different entities when making survival predictions.

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Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre

Cited by 15 publications

References 15 publications

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Authors’ reply: Comment on: Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

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