Vulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series

Sartor, Rita Abigail; Lawson, Ashli; Moncada-Madrazo, Mariana; Altchek, Chloé; Vash‐Margita, Alla; Cron, Julia

doi:10.1016/j.jpag.2023.01.003

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…21 This proinflammatory milieu could, therefore, be related not only to the typical clinical manifestations of COVID-19 but also to these cutaneous signs. 6,19 In conclusion, SARS-CoV-2 pandemic seems to be related to acute genital ulcerations in a double way: on the one hand, COVID-19 infection and vaccination is being recognized as an emerging trigger of LU, [4][5][6][7][8][9][10][11][12][13] and on the other hand, restrictive measures implemented during lockdown have produced an increase in child abuse. [14][15][16] The awareness of LU, even though it represents a rare entity, helps to avoid unnecessary investigations, and treatment, and to possibly reduce patients and family anxiety.…”

Section: Discussionmentioning

confidence: 99%

“…21 This proinflammatory milieu could, therefore, be related not only to the typical clinical manifestations of COVID-19 but also to these cutaneous signs. 6,19…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, SARS-CoV-2 pandemic seems to be related to acute genital ulcerations in a double way: on the one hand, COVID-19 infection and vaccination is being recognized as an emerging trigger of LU, 4–13 and on the other hand, restrictive measures implemented during lockdown have produced an increase in child abuse. 14–16…”

Section: Discussionmentioning

confidence: 99%

“…1 More recently, during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, LU cases appear either related to SARS-CoV-2 vaccination or infection. [4][5][6][7][8][9][10][11][12][13] Moreover, SARS-CoV-2 pandemic resulted in restricted social and school activities, psycho-physical stress, and work issues that caused a rise in child abuse, 14,15 even if this condition remains underdetected 16 ; therefore, clinicians should remain vigilant of sexual child abuse as a mimicker of LU, focusing also on the girl's safety and security, comfortable environment, and psychological support. We describe 2 girls who presented in the pediatric emergency room (ER) with acute vulvar ulcers during SARS-CoV-2 pandemic.…”

Section: Introductionmentioning

confidence: 99%

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Lipschütz ulcers due to SARS-CoV-2 infection: a neglected diagnosis in emergency room

Brambilla,

Bolcato,

Volonté

et al. 2024

International Journal of Women’s Dermatology

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Background: Primary acute genital ulcers, or Lipschütz ulcers (LU), are nonsexually transmitted, painful, self-limiting, nonrecurrent vulvar ulcers with unclear pathogenesis, representing a challenging diagnosis in emergency setting. LU have recently been described in association with severe acute respiratory syndrome coronaVirus 2 (SARS-CoV-2) infection and vaccination. Objective: The aim of this study is to describe 2 cases of LU due to SARS-CoV-2 infection, highlighting the diagnostic process, differential diagnosis, disease course, and management options. Methods: We describe 2 young females (12 and 9 years old) who presented to pediatric emergency room with the sudden onset of well-demarcated, painful, vulvar ulcers with fibrinous necrotic center. Results: Both patients tested positive to SARS-CoV-2 nasal swab, and, at physical examination, no other lesions were found in other cutaneous or mucosal sites. Sexual abuse was excluded in both cases, as well as infectious and autoimmune diseases. Supportive analgesic therapy was administered, and complete remission of lesions was observed at follow-up visits without evidence of scarring. Limitations: The main limitation of this work is represented by the small number of cases described. Conclusion: Even though extremely rare, LU related to COVID-19 are an emerging entity to be considered in the diagnosis of acute genital ulcerations. Multidisciplinary diagnostic workup of genital ulcers must be established in order to exclude sexual child abuse, to ensure patient safety, and to avoid unnecessary treatment and familial anxiety.

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Section: Discussionmentioning

confidence: 99%

“…21 This proinflammatory milieu could, therefore, be related not only to the typical clinical manifestations of COVID-19 but also to these cutaneous signs. 6,19…”

Section: Discussionmentioning

confidence: 99%