Vulnerable Atherosclerotic Plaque

Correlation of Vulnerable Coronary Plaques to Sudden Cardiac Events. Lessons from a Myocardial Infarction-prone Animal Model (the WHHLMI Rabbit)

“…In sudden cardiac events, plaque rupture is the most common cause of plaque complications. Rupture-prone plaques, which are characterized by possessing an easily disrupted/fissured and occlusive thrombus, have a large lipid core and a thin fibromuscular cap accompanied by many macrophages and other inflammatory cells on or beneath the cap surface (6)(7)(8).…”

“…These enzymes are considered to make the fibrous cap fragile (7-9) because they can digest the extracellular matrix in the fibrous cap and subsequently lead to thrombus formation (7)(8)(9). Based on such studies, rupture-prone plaques have come to be considered a crucial trigger in the process of sudden cardiac events and also a target for clinical intervention.…”

Identification of heterogeneous elastic properties in stenosed arteries: a numerical plane strain study

“…Computer Methods in Biomechanics and Biomedical Engineering, 2011, 14(12), [1][2][3][4][5][6][7][8][9][10] The reference data are the result of the computation of a FE model with about 130 000 CPE8H elements (hybrid plane strain quadratic quadrangular elements). This element allows to treat the hydrostatic pressure as an independent variable and is recommended for quasiincompressible cases (ABAQUS 6.…”

“…But it is more difficult to draw conclusions for patients with moderate stenosis. Moreover the phenomenon of artery remodelling makes this geometrical criterion alone insufficient (Casscells et al 2003).…”

“…Computer Methods in Biomechanics and Biomedical Engineering, 2011, 14(12), [1][2][3][4][5][6][7][8][9][10] The originality of this study is to numerically investigate the identifiability of the heterogeneities elastic parameters from simulated PC-MRI data (Draney et al 2002). In particular, the effects of the FE mesh, of the a priori parameters values, of the data spatial resolution and of white noise corrupting experimental data are studied.…”