The study is motivated by the quality degradation of groundwater with emphasis on salinity between 2012 and 2018 in an aquifer, namely Azarshahr aquifer, located in Western Asia (a case of north-west of Iran), adjacent to Lake Urmia. The groundwater of Azarshahr plain in the south-east, namely, the nutritional zone of the plain, has a low amount of salts (0.7–18.06 mg/L), but by moving to the north-west and west of the plain, which is the location of the outflow of water, the concentration of salts is significantly increased (35.42–87.5 mg/L). Ca–Cl has the cardinal influence on quality of water, making it different from the common type of fresh waters in Iran (Ca–HCO3). High concentrations of SO42−, Cl−, and Na+ detected in almost all the water samples, which indicates aquifer’s good quality for portable applications. Regarding agricultural applications, from 2012 to 2018, the percentage of samples in the good class of C2S1 has been reduced by 35%, which could also be a further indicator of increasing salinity in the aquifer. The spatial distribution of electrical conductivity (EC), cations, and anions tends to follow an increasing pattern toward western regions. Comparing the results of hydrochemical analysis of Lake Urmia with the corresponding results from the groundwater in Azarshahr plain, there is an acceptable correlation between the hydrochemical features of Lake Urmia with the saltwater of western parts of the Azarshahr plain. Hence, it is likely that another source of water salination in this plain, especially in western parts, is the influx from Urmia Lake. Due to the presence of clay mass of mountains between the Lake Urmia and Azarshahr plain as well as the lack of a hydraulic relationship, the probability of penetration of saline water from reinforced water reservoirs of Lake Urmia to the aquifer of Azarshahr plain is further strengthened.