Vulnerability and Resilience of Estuaries to Contamination by Antibiotics and Antibiotic‐Resistant Bacteria: A Challenge for the Next Decade

Petit, Fabienne; Berthe, Thierry; Budzinski, Hélène; Leclercq, Roland; Cattoir, Vincent; Andremont, Antoine; Oberlé, Kenny; Laverman, Anniet M.; Denamur, Erick

doi:10.1002/9781119007739.ch2

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…Anthropogenic activities such as aquaculture, livestock and poultry farming, chemical/pharmaceutical production, and residential activities generate large amounts of waste that contains various antimicrobial compounds, such as heavy metals, biocides, human/animal medicines, and antibiotics. These wastes can be released, sometimes without any treatments, to the various environments and consequently promote selective pressures for the development of antibiotic-resistant bacteria and genes [19][20][21][22]. In addition, with current technology, even in developed countries, the removal capacity in wastewater treatment plants has been reported to not be adequate in regard to eliminating antibiotics and ARGs [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic Resistance Genes in the Saigon River Impacted by Anthropogenic Activities

Truong

Hoang²,

Tran

et al. 2021

Water

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Despite of a high abundance of antibiotics, heavy metals, and organic matters detected in the Saigon River in Ho Chi Minh City, the level and spread of antibiotic resistance genes in this river are poorly understood. In this study, total 10 antibiotic resistance genes (ARGs), including genes conferring resistance to aminoglycosides (aac(6)-Ib-cr), β-lactam antibiotics (blaCTX-M, blaSHV, blaTEM), quinolones (qnrA, qnrB), sulfonamides (sul1, sul2), trimethoprim (dfrA), efflux pump (oqxB), and three genes of genetic elements, including integron classes 1, 2, and 3 (intI1, intI2, intI3), are quantified by qPCR. Water samples were collected from the industrial, agricultural, residential, and less impacted areas for the wet and dry seasons. The results present high occurrence rates for 10 ARGs that were observed in all the sampling sites with the following order: sul1, sul2, dfrA > aac(6)-Ib-cr > blaCTX-M, blaSHV, blaTEM > qnrA, qnrB. Although the levels of ARGs and integrons in the dry season were found about to be about one order of magnitude higher than those in the wet season, the exact mechanisms for this are not fully clear. The correlation analysis presented here suggests that the contamination of organic matter and nutrients from agricultural, industrial, and residential activities likely contributes to the prevalence of ARGs, integrons, total bacterial load, and the potential development and spread of antibiotic resistance in the aquatic environments considered here.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic Resistance Genes in the Saigon River Impacted by Anthropogenic Activities

Truong

Hoang²,

Tran

et al. 2021

Water

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“…Wastes arising from human activities are rich in recalcitrant compounds such as antimicrobials, metals and biocides, which can reach water bodies and contribute significantly to the selection of resistant bacteria phenotypes (Petit et al, 2014). Although water courses seem to play a key role in the maintenance of resistance phenotypes in nature, little attention has been paid to the influence of human activities on the prevalence of resistance in these resources (Pruden et al, 2012;Czekalski et al, 2015;Yang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance in surface waters from a coastal lagoon of Southern Brazil under the impact of anthropogenic activities

Leite¹,

Chaves²,

Nunes³

et al. 2019

Rev. ambiente água

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Wastes arising from human activities can reach water bodies and contribute significantly to the presence of antibiotic resistant bacterial populations in aquatic environments. The objective of this study was to evaluate the cultivable antibiotic resistant bacterial populations from a coastal lagoon impacted by agriculture and urbanization activities. Water samples were collected in low and peak season and characterized regarding physicochemical variables, microbiological indicators and the presence of antimicrobial residues. In order to analyze the presence of resistant bacterial populations, the samples were grown in the presence of nalidixic acid, ceftazidime, imipenem and tetracycline. Genes associated with β-lactamic resistance (blaCTX-M-like, blaGES-like, blaOXA-51, blaOXA-23-like, blaSHV-like, blaTEM-like and blaSPM-1), class I integron and efflux systems (tetA, tetB, acrA, acrB, tolC, adeA, adeB, adeR, adeS, mexB, mexD, mexF and mexY) were analyzed by conventional in vitro amplification. Although antimicrobials residues were below the detection limit, resistant bacteria and resistance determinants - blaGES, class I integron, adeS, acrA, acrB, tolC, mexB, mexF - were present at almost all points, in both seasons and for all antimicrobials assessed. The high numbers of resistant bacteria counts observed after the antibiotic treatment were positively correlated to the urbanization effects on the Lagoon. Some resistant populations were even higher in the low season samples, indicating the importance of a systematic evaluation of antibiotic resistance on water resources.

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Management of the Marine Environment: Transdisciplinary and Systemic Approach

Prouzet¹,

Monaco

Sébastien³

2019

Encyclopedia of Water

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Since the beginning of the twentieth century, observations have shown a significant degradation of aquatic environments. This degradation has got worse in the past century in all regions of the Globe. This is observed in many estuarine areas vital for the growth of high‐value species. Given the state of degradation of these coastal environments, their vulnerability to the anthropic effects and the natural hazards has become stronger whereas their resilience capacities have become significantly lower. The same goes for the many human communities living from the exploitation of living resources that can no longer ensure the sustainability of their fishing or farming activities. In addition to all these modifications the impacts, now proven, of climate change alter the temperature of water masses and biogeochemical characteristics of marine ecosystems. This integrated vision of the marine environment and of the aims of research makes it possible to address the issue of environmental governance and the problems involved in coordinating the knowledge and functions of scientific, social, economic and political actors. The three authors who are specialized in different fields of research exchange their points of view, redefine the terms, notions, concepts, and the questions related to the exercise of transdisciplinarity.

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Vulnerability and Resilience of Estuaries to Contamination by Antibiotics and Antibiotic‐Resistant Bacteria: A Challenge for the Next Decade

Cited by 4 publications

References 65 publications

Prevalence of Antibiotic Resistance Genes in the Saigon River Impacted by Anthropogenic Activities

Prevalence of Antibiotic Resistance Genes in the Saigon River Impacted by Anthropogenic Activities

Antibiotic resistance in surface waters from a coastal lagoon of Southern Brazil under the impact of anthropogenic activities

Management of the Marine Environment: Transdisciplinary and Systemic Approach

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