Vrk1

Abstract

OverviewIntracellular membrane trafficking in eukaryotes is a multiple step process consisting in the budding of vesicles from a donor compartment, their translocation into the cytoplasm along cytoskeletal elements, their tethering, and subsequent fusion with the membrane of the target compartment. Membrane fusion is based on SNARE proteins, classified into two categories, vesicular (v)-SNAREs and target (t)-SNAREs present on the acceptor membrane. It is the specific pairing of v-SNAREs with their cognate t-SNAREs in trans which is responsible for bringing the lipid bilayers close together, and the zippering of SNAREs