VRE fecal colonization/infection in cancer patients

Rolston, Kenneth V. I.; Jiang, Ying; Matar, Madonna

doi:10.1038/sj.bmt.1705639

Cited by 17 publications

(11 citation statements)

References 5 publications

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“…Previous studies from larger centers have reported highly variable VRE colonization rates in HSCT recipients ranging from 5% to 27%, although the rates of VRE bacteremia among colonized patients was similar: approximately 30% across all studies [5,10,11]. A previous study from MSKCC (between August 2004 and February 2006) showed a colonization rate of 29%; 27 among 92 HSCT recipients screened prior to transplant were VRE colonized, and 34% of all colonized persons developed VREB early (within first 35 days) after HSCT [4].…”

Section: Discussionmentioning

confidence: 99%

The Changing Epidemiology of Vancomycin-Resistant Enterococcus (VRE) Bacteremia in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Kamboj

Chung

Seo

et al. 2010

Biology of Blood and Marrow Transplantation

117

105

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The impact of the rising prevalence of vancomycin-resistant Enterococcus (VRE) prior to hematopoietic stem cell transplantation (HSCT) and changes in transplant techniques on risk of VREB (VRE bacteremia) early after HSCT is not known. This is a retrospective study of 247 adult patients who underwent allogeneic HSCT in the years 2008 and 2009 at the Memorial Sloan-Kettering Cancer Center. Sixty-eight of 247 (27.5%) patients were VRE colonized on pretransplant screening. VRE was the leading cause of bacteremia in the first 30 days after HSCT; 23 of 43 (53.5%) patients with positive blood cultures had VRE. Only 13 (57%) of the 23 patients with early VREB were colonized with VRE on pre-HSCT screening cultures. Mortality was directly attributable to VRE infection in 9% of patients with early VREB. VRE is emerging as the most common cause of preengraftment bacteremia in patients undergoing allogeneic HSCT, and is associated with substantial mortality. Pre-HSCT screening for VRE with stool cultures will not identify all patients who are at risk for VREB. The use of alternate agents with activity against Gram-positive bacteria for fever and neutropenia early after HSCT should be evaluated further in prospective studies.

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Section: Discussionmentioning

confidence: 99%

The Changing Epidemiology of Vancomycin-Resistant Enterococcus (VRE) Bacteremia in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Kamboj

Chung

Seo

et al. 2010

Biology of Blood and Marrow Transplantation

117

105

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show abstract

“…Rolston and colleagues 19 looked at patients with hematologic malignancies and found that VRE colonization had a positive predictive value of 29.3% (29/99) for VRE bacteremia and a negative predictive value of 99.9% (2014/2016). Kim and colleagues 27 described a prospective study in an intensive care unit in which 9.2% (17/184) of VRE-colonized patients experienced VRE sterile-site infections.…”

Section: Discussionmentioning

confidence: 99%

“…14 Previous studies have evaluated the predictive value of VRE screening swabs in forecasting the prevalence of VRE among all causes of bacterial infection. [15][16][17][18][19] In this study, we sought to investigate the utility of results obtained with VRE screening swabs in predicting vancomycin resistance among subsequent sterile-site infections with Enterococcus. We hypothesized that among patients with sterile-site Enterococcus infections, prior positive results with VRE screening swabs would reliably predict vancomycin resistance, but prior negative results would not reliably rule out vancomycin resistance.…”

mentioning

confidence: 99%

Predictive utility of swab screening for vancomycin-resistant Enterococcus in selection of empiric antibiotics for Enterococcus sterile-site infections: a retrospective cohort study

et al. 2017

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“…Other studies described rates of early bacteremia with VRE ranging between 3% and 22% and mortality rates varying between 1% and 80% . Rates of VRE bacteremia among colonized patients account for approximately 30% in several analyses . Recently, Bilinski et al .…”

Section: Discussionmentioning

confidence: 99%