Since the phenylalanine (Phe) dipeptide
moiety is referred
to as
an essential structure for building amyloid-β peptide from Alzheimer’s
disease, its wonderful assembly ability to form nanofibers has been
extensively studied. Cross-linked Phe–Phe-based peptide nanofibers
can construct networks, thus encapsulating the drugs to form supramolecular
hydrogels. Recently, scientists have proposed a variety of Phe–Phe-based
macroscopic supramolecular hydrogels and used them in biomedical applications.
Therefore, we summarize the construction strategies of Phe–Phe-based
macroscopic supramolecular hydrogels and list their represented biomedical
applications (e.g., wound healing, eye protection,
cancer therapy, etc.) since the birth of Phe–Phe-based
supramolecular hydrogels. In addition, we present the perspectives
and challenges of Phe–Phe-based macroscopic peptide hydrogels.