VP63.12: Endometrial pathology in asymptomatic tamoxifen users: the experience of a Portuguese tertiary referral centre

Abstract

Virtual poster abstracts Methods: Systematic review of papers in PubMed, EMBASE and Cochrane computerised bibliographic databases for eligible studies. Peer reviewed studies including RCTs, prospective and retrospective cohort and case-control studies with more than 10 patients were eligible. When available, contrast-enhancement ultrasound characteristics for the tissue studied, data on diagnostic accuracy, sensitivity, specificity, negative and positive predictive value, interclass correlation coefficient was extracted or calculated. Results: 26 studies met our inclusion criteria. The results entail a detailed description of contrast-enhancement characteristics of different types of tissue, providing a basis for diagnostic differentiation in gynecology. CEUS readily showed to be applicable for monitoring of therapies and predicting the best treatment option. This review also shows the limited number of methodological high-quality clinical studies and structural reports on CEUS application in gynecology. Conclusions: CEUS is a promising diagnostic tool, however, if we aim at an established role of CEUS in daily gynecological practice, we should make a joined effort in setting up methodological high-quality clinical studies with appropriate reference testing, and report contrast-enhancement characteristics and quantitative parameters in a consistent manner. VP63.12 Endometrial pathology in asymptomatic tamoxifen users: the experience of a Portuguese tertiary referral centre