VP49.01: Outcome of pregnancy complicated by second trimester prelabour rupture of membranes: a prospective cohort study

Abstract

aortic pulse wave velocity (PWVao) at four pre-specified gestational windows (11-19 +6 , 20-27 +6 , 28-33 +6 , ≥34 weeks). Results were compared to controls (n = 78), using parametric and non-parametric tests. Results: 63 data sets were obtained from women with pre-existing diabetes mellitus and 80 data sets from the low-risk control group. PWVao was found to be consistently higher amongst pregnant women with pre-existing diabetes mellitus than in low-risk controls throughout pregnancy, reaching statistical significance at 20-27 +6 and ≥34 weeks of gestation (p < 0.001). Conclusions: Our study demonstrates that pregnant women with type 1 and type 2 diabetes mellitus possess different hemodynamics compared to low-risk controls, with arterial stiffness significantly higher in the second and third trimester. A larger, longitudinal study is required to assess the value of arterial stiffness measurements as a prognostic marker for pregnancy complications in this population.