Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

Abstract

A voxel-wise longitudinal PRM analytic approach can identify patterns of disease progression in smokers with and without chronic obstructive pulmonary disease.

Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation

“…Parametric response mapping of paired CT has been investigated extensively as an analytical technique to better phenotype airway obstruction in COPD . Most of these studies are associated with multicenter observational trials such as the COPDGene and SPIROMICS, where imaging protocols are selected to produce image quality consistent across participating sites.…”

“…A clear trend between the contribution of fSAD and PD is observed. FH, Fred Hutchinson Cancer Research Center; fSAD, functional small airways disease; KI, Karolinska University Hospital; PD, parenchymal disease; PRM, parametric response mapping; UM, University of Michigan airway obstruction in COPD [21][22][23][24][25][26]. Most of these studies are associated with multicenter observational trials such as the COPDGene and SPIROMICS,27,28 where imaging protocols are selected to pro-duce image quality consistent across participating sites.…”

Advances in Chronic Obstructive Pulmonary Disease Imaging

“…Prior studies have suggested that small airways disease is a precursor of emphysema 1 . The investigators have provided further evidence on this notion by demonstrating that baseline PRM fSAD is independently associated with emphysema at 5-yr follow-up 67 . Other investigators have shown that the lobar distribution of emphysema is also related to different patterns of progression.…”

Insights into Chronic Obstructive Pulmonary Disease Epidemiology, Phenotypes and Outcomes from SPIROMICS

“…Mathematical model simulations showed that fSAD may be a transitional pathologic phase between normal lung and emphysema 30 . Subsequent 5-year longitudinal analyses from COPDGene supported this hypothesis 31 . In summary, these remarkable advances in chest imaging have improved our understanding of COPD and have helped characterise some of its clinical phenotypes.…”