Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses

Shin, Yong Beom; Kim, Seong-Jang; Kim, In-Ju; Kim, Yong-Ki; Kim, Dong-Soo; Park, Jae Heung; Yeom, Seok Ran

doi:10.1080/02699050600677071

Cited by 28 publications

(11 citation statements)

References 20 publications

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“…PET and SPECT studies of mild TBI consistently have found deficits in prefrontal metabolic activity (e.g. Fontaine et al 1999;Shin et al 2006;Kato et al 2007;Lewine et al 2007). A handful of mild TBI fMRI executive function studies to date have, for the most part, found relative deficits in lateral prefrontal cortex activation similar to PET/SPECT research (Chen et al 2003(Chen et al , 2004(Chen et al , 2008Ptito et al 2007;Lovell et al 2007;Mayer et al 2009).…”

Section: Introductionmentioning

confidence: 84%

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Witt

Lovejoy

Pearlson

et al. 2010

Brain Imaging and Behavior

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Up to one-third of patients with mild traumatic brain injury (TBI) demonstrate persistent cognitive deficits in the 'executive' function domain. Mild TBI patients have shown prefrontal cortex activity deficits during the performance of executive tasks requiring active information maintenance and manipulation. However, it is unclear whether these deficits are related to the executive processes themselves, or to the degree of mental effort. To determine whether prefrontal deficits also would be found during less effortful forms of executive ability, fMRI images were obtained on 31 mild TBI patients and 31 control participants during three-stimulus auditory oddball task performance. Although patients and controls had similar topographical patterns of brain activity, region-of-interest analysis revealed significantly decreased activity in right dorsolateral prefrontal cortex for mild TBI patients during target stimulus detection. Between-group analyses found evidence for potential compensatory brain activity during target detection and default-mode network dysfunction only during the detection of novel stimuli.

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Section: Introductionmentioning

confidence: 84%

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Witt

Lovejoy

Pearlson

et al. 2010

Brain Imaging and Behavior

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“…Since TBI might occur in different areas in each patient, one might expect group SPM analysis of TBI to show little significance. However, SPM analysis of PET and SPECT images has identified a number of abnormalities in a wide number of areas, including the frontal lobe (Kato et al, 2007;Levine et al, 2002;Nakayama et al, 2006;Shin et al, 2006;Stamatakis et al, 2002), temporal lobe (Kato et al, 2007;Stamatakis et al, 2002), hippocampus (Shin et al, 2006), parahippocampal gyrus (Shin et al, 2006), and cerebellum (Kato et al, 2007) during performance on a task or at rest. It is unclear from these analyses whether the group SPM abnormalities were due to focal lesions of large intensity scattered widely across the brain in different individuals, or due to diffuse uptake tracer decreases across several brain regions in many group members.…”

Section: Introductionmentioning

confidence: 99%

Statistical Parametric Mapping and Cluster Counting Analysis of [¹⁸F] FDG-PET Imaging in Traumatic Brain Injury

Zhang

Mitsis

Chu

et al. 2010

Journal of Neurotrauma

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In this study we investigated regional cerebral glucose metabolism abnormalities of [(18)F] fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in traumatic brain injury (TBI). PET images of 81 TBI patients and 68 normal controls were acquired and a word list learning task was administered during the uptake period. The TBI group included 35 patients with positive structural imaging (CT or MRI) findings soon after injury, 40 patients with negative findings, and 6 cases without structural imaging. Statistical parametric mapping (SPM) analysis was applied with several levels of spatial smoothing. Cluster counting analysis was performed for each subject to identify abnormal clusters with contiguous voxel values that deviated by two standard deviations or more from the mean of the normal controls, and to count the number of clusters in 10 size categories. SPM maps demonstrated that the 81 patients had significantly lower FDG uptake than normal controls, widely across the cortex (including bilateral frontal and temporal regions), and in the thalamus. Cluster counting results indicated that TBI patients had a higher proportion of larger clusters than controls. These large low-FDG-uptake clusters of the TBI patients were closer to the brain edge than those of controls. These results suggest that deficits of cerebral metabolism in TBI are spread over multiple brain areas, that they are closer to the cortical surface than clusters in controls, and that group spatial patterns of abnormal cerebral metabolism may be similar in TBI patients with cognitive deficits with and without obvious acute abnormalities identified on structural imaging.

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“…241 Researchers also are showing a renewed interest in the autoregulatory vascular and rCBF effects that occur as a result of head trauma. 242 As nuclear medicine continues to progress through the era of molecular imaging, numerous novel radiopharmaceuticals currently in development or being used for research purposes may be 241 Researchers also are showing a renewed interest in the autoregulatory vascular and rCBF effects that occur as a result of head trauma. 242 Nuclear medicine brain SPECT potential for TBI neuroimaging TBI may encompass a multitude of pathological findings, and clinical presentation, such as post-concussive syndrome, may represent an overlap of other concurrent disease processes or preexisting processes.…”

Section: Single Photon Emission Computed Tomographymentioning

confidence: 99%

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

Amyot

Arciniegas

et al. 2015

Journal of Neurotrauma

175

147

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The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in 2009, according to the Centers for Disease Control and Prevention. It is a contributing factor in 30.5% of injury-related deaths among civilians. Additionally, since 2000, more than 260,000 service members were diagnosed with TBI, with the vast majority classified as mild or concussive (76%). The objective assessment of TBI via imaging is a critical research gap, both in the military and civilian communities. In 2011, the Department of Defense (DoD) prepared a congressional report summarizing the effectiveness of seven neuroimaging modalities (computed tomography [CT], magnetic resonance imaging [MRI], transcranial Doppler [TCD], positron emission tomography, single photon emission computed tomography, electrophysiologic techniques [magnetoencephalography and electroencephalography], and functional near-infrared spectroscopy) to assess the spectrum of TBI from concussion to coma. For this report, neuroimaging experts identified the most relevant peer-reviewed publications and assessed the quality of the literature for each of these imaging technique in the clinical and research settings. Although CT, MRI, and TCD were determined to be the most useful modalities in the clinical setting, no single imaging modality proved sufficient for all patients due to the heterogeneity of TBI. All imaging modalities reviewed demonstrated the potential to emerge as part of future clinical care. This paper describes and updates the results of the DoD report and also expands on the use of angiography in patients with TBI.

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Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses

Cited by 28 publications

References 20 publications

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Statistical Parametric Mapping and Cluster Counting Analysis of [¹⁸F] FDG-PET Imaging in Traumatic Brain Injury

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

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Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: Group and individual analyses

Cited by 28 publications

References 20 publications

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Statistical Parametric Mapping and Cluster Counting Analysis of [18F] FDG-PET Imaging in Traumatic Brain Injury

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

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Statistical Parametric Mapping and Cluster Counting Analysis of [¹⁸F] FDG-PET Imaging in Traumatic Brain Injury