Voxel-Based Morphometry in Individual Patients: A Pilot Study in Early Huntington Disease

Mühlau, Mark; Wohlschläger, A. M.; Gaser, Christian; Valet, M.; Weindl, A.; Nunnemann, Sabine; Peinemann, Alexander; Etgen, Thorleif; Ilg, Rüdiger

doi:10.3174/ajnr.a1390

Cited by 58 publications

(49 citation statements)

References 39 publications

(23 reference statements)

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“…Statistical analysis included voxel-wise Crawford's modified t test for single-subject assessment (Crawford and Howell 1998), which can be easily implemented as a general linear model in SPM8 by changing the default option to `equal variance' (Mühlau et al 2009). Age and gender were included in the statistical model as covariates.…”

Section: Methodsmentioning

confidence: 99%

Visual imagery and functional connectivity in blindness: a single-case study

et al. 2015

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We present a case report on visual brain plasticity after total blindness acquired in adulthood. SH lost her sight when she was 27. Despite having been totally blind for 43 years, she reported to strongly rely on her vivid visual imagery. Three-Tesla magnetic resonance imaging (MRI) of SH and age-matched controls was performed. The MRI sequence included anatomical MRI, resting-state functional MRI, and task-related functional MRI where SH was instructed to imagine colours, faces, and motion. Compared to controls, voxel-based analysis revealed white matter loss along SH's visual pathway as well as grey matter atrophy in the calcarine sulci. Yet we demonstrated activation in visual areas, including V1, using functional MRI. Of the four identified visual resting-state networks, none showed alterations in spatial extent; hence, SH's preserved visual imagery seems to be mediated by intrinsic brain networks of normal extent. Time courses of two of these networks showed increased correlation with that of the inferior posterior default mode network, which may reflect adaptive changes supporting SH's strong internal visual representations. Overall, our findings demonstrate that conscious visual experience is possible even after years of absence of extrinsic input.

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Section: Methodsmentioning

confidence: 99%

Visual imagery and functional connectivity in blindness: a single-case study

et al. 2015

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“…Future studies including larger number of participants and providing neuropathological data will be needed to confirm this hypothesis. Regarding MRI analysis, although single-subject voxel-based morphometry is not statistically ideal, it has proven to be a useful technique used in numerous studies of patients with neurodegenerative disease [19–21]. …”

Section: Discussionmentioning

confidence: 99%

Logopenic Aphasia due to a Strategic Stroke: New Evidence from a Single Case

Riancho

Pozueta

Santos

et al. 2017

JAD

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Among primary progressive aphasias (PPAs), logopenic variant PPA (lv-PPA) is usually related to Alzheimer’s disease. Although it has been widely clinically and pathologically evaluated, the topography in LPA is still controversial. We report a patient presenting with a logopenic syndrome due to a strategic lesion located in the superior and middle temporal gyrus and compare our findings with those of a PiB-PET positive lv-PPA patient matched by age, gender, and education. We consider that our study provides new anatomical clues to better understand the cognitive mechanisms underlying the logopenic syndrome.

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“…Huntington's disease causes muscles discoordination and cognitive and behavioral alterations. The finding of ventricular dilatation, as well as basal ganglia atrophy, is very sensitive, but poorly specific (26,27) .…”

Section: "Tram-track Sign" In Optic Nerve Sheath Meningiomamentioning

confidence: 99%

Sinais em neurorradiologia: parte 2

et al. 2011

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The use of signs for interpretation of images in neuroradiology is extremely useful. Some signs are quite specific and, in some cases, pathognomonic. In this second part of their essay, the authors describe 15 additional neuroradiological signs. Main characteristics of imaging findings will be approached and the significance of their role in the clinical practice will be discussed. Keywords: Radiological signs; Neuroradiology; Computed tomography; Magnetic resonance imaging.O uso de sinais na interpretação de imagens na neurorradiologia é extremamente útil. Muitos sinais são bastante específicos e em alguns casos, patognomônicos. Nesta segunda parte os autores descreverão 15 sinais neurorradiológicos adicionais. Serão novamente abordadas as principais características de imagem de cada um e sua importân-cia na prática clínica. Unitermos: Sinais radiológicos; Neurorradiologia; Tomografia computadorizada; Imagem por ressonância magnética. Abstract "High heel foot print sign" in the skull baseThe high heel foot print sign (Figure 1) is useful in the understanding of the intricate anatomy of the skull base and represent two relevant foramina. The anterior aspect of the high heel footprint represents the foramen ovale (FO), and the posterior aspect (the heel itself) the foramen spinosum (FS). The mandibular nerve, one of the three branches of the trigeminal nerve, is the main FO component (1) . Also, the otic Figure 1. Axial CT image demonstrating normal appearance of the skull base. The high heel foot print sign is evidenced. The small arrow indicates the foramen spinosum, and the large arrow, the foramen ovale. Anteriorly to the high heel footprint is the Vesalius foramen (venous foramen) (arrowhead). ganglion, the accessory meningeal artery, the lesser petrosal nerve and the emissary veins are found in this foramen. The middle meningeal artery is in the FS (2) , and the absence of such artery is related to the persistent stapedial artery (3) . "Lemon sign" in spina bifidaThe lemon sign (Figure 2) is an useful sign in the detection of spina bifida and is commonly associated with hydrocephalus and Arnold-Chiari II malformation (4) . Such sign can be found in up to 98% of cases of spina bifida (5) . The lemon sign is not exclusive to spina bifida and can be observed in cases of encephalocele, thanatophoric dys-

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Voxel-Based Morphometry in Individual Patients: A Pilot Study in Early Huntington Disease

Cited by 58 publications

References 39 publications

Visual imagery and functional connectivity in blindness: a single-case study

Visual imagery and functional connectivity in blindness: a single-case study

Logopenic Aphasia due to a Strategic Stroke: New Evidence from a Single Case

Sinais em neurorradiologia: parte 2

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