Voxel-based morphometric gray matter correlates of daytime sleepiness

Gray matter atrophy in narcolepsy: An activation likelihood estimation meta-analysis

“…The hypothalamus, NAcc, PFC, and temporal lobe are specifically vulnerable to this disease. The correlations found between imaging alterations and neurocognitive deficits in these regions are consistent with previous reports that hypothalamus plays a significant role in the neuronal losses affecting hypocretinergic structures (Row, 2007) and the PFC is involved in daytime sleepiness (Killgore et al, 2012) and positive emotions (Oishi et al, 2013). These findings indicate that the narcoleptic morphological diminutions may implicate a network of brain regions reflecting the altered hypocretinergic structures as well as the main cognitive symptoms such as memory, attention, and executive functions involved in narcolepsy.…”

Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults

“…The MRI sleep literature to date has most frequently reported associations between sleep quality and the OFC and wider mPFC, with smaller volume linked with a diagnosis of primary insomnia, 4,5 greater severity of insomnia symptoms, 4 daytime sleepiness, 9 early-morning awakening, 8 and reduced "sleep credit" (i.e., the difference between habitual sleep and subjectively reported minimum hours of sleep needed) 22 and NREM SWA. 10 Although our cross-sectional analyses did not find relationships between sleep quality and mPFC volume, longitudinal analyses detected significant correlations between sleep quality and atrophy within the OFC and mPFC.…”

“…5 Although few studies have explored the relationship between sleep and brain structure in healthy individuals, crosssectional correlations have been reported between the volume of the OFC and early-morning awakening 8 and daytime sleepiness. 9 Furthermore, reduction in non-REM (NREM) slow wave activity (SWA) in older adults has been associated with age-related decreases in gray matter density within the medial prefrontal cortex (mPFC). 10 To our knowledge, no studies have assessed the relationship between sleep quality and longitudinal change in brain structure.…”

Understanding Recent Insights in Sleep and Posttraumatic Stress Disorder from a Research Domain Criteria (RDoC) Framework

“…Cells A number of studies have shown that reduced gray matter volume in regions of the ventromedial prefrontal cortex (vmPFC) is associated with sleep complaints such as chronic insomnia [21], excessive daytime sleepiness [22], and obstructive sleep apnea [23]. Structural changes in the brain are also present in individuals with both sleep and trauma-related symptom complaints.…”