Voxel-based lesion symptom mapping analysis of depressive mood in patients with isolated cerebellar stroke: A pilot study

Kim, Na Young; Lee, Sang Chul; Shin, Ji Cheol; Park, Ji Eun; Kim, Yong-Wook

doi:10.1016/j.nicl.2016.11.011

Cited by 25 publications

(27 citation statements)

References 58 publications

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“…To date, there has been minimal sophisticated lesion-symptom mapping in the affective domain. One exception is a recent voxel-based study by Kim and colleagues [61], where left posterior CB damage was associated with depressive mood severity in 24 patients with isolated CB stroke ( Fig. 2).…”

Section: Relating Function To Structure In Cerebellar Diseasementioning

confidence: 93%

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

et al. 2019

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Sporadically advocated over the last two centuries, a cerebellar role in cognition and affect has been rigorously established in the past few decades. In the clinical domain, such progress is epitomized by the "cerebellar cognitive affective syndrome" ("CCAS") or "Schmahmann syndrome." Introduced in the late 1990s, CCAS reflects a constellation of cerebellar-induced sequelae, comprising deficits in executive function, visuospatial cognition, emotion-affect, and language, over and above speech. The CCAS thus offers excellent grounds to investigate the functional topography of the cerebellum, and, ultimately, illustrate the precise mechanisms by which the cerebellum modulates cognition and affect. The primary objective of this task force paper is thus to stimulate further research in this area. After providing an up-to-date overview of the fundamental findings on cerebellar neurocognition, the paper substantiates the concept of CCAS with recent evidence from different scientific angles, promotes awareness of the CCAS as a clinical entity, and examines our current insight into the therapeutic options available. The paper finally identifies topics of divergence and outstanding questions for further research.

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Section: Relating Function To Structure In Cerebellar Diseasementioning

confidence: 93%

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

et al. 2019

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“…Recently, increased understanding of brain networks involved in the pathophysiology of depression ( 50 ) motivated more refined anatomic interpretation of stroke lesion location linked to PSD. Furthermore, severity of PSD was reported to be associated with lesion location ( 51 , 52 ) but not with lesion size ( 52 ).…”

Section: Association Of Stroke Lesion With Psdmentioning

confidence: 99%

Post-Stroke Depression: Impact of Lesion Location and Methodological Limitations—A Topical Review

Nickel

Thomalla

2017

Front. Neurol.

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Post-stroke depression (PSD) affects approximately one-third of all stroke patients. It hinders rehabilitation and is associated with worse functional outcome and increased mortality. Since the identification of PSD is a significant clinical problem, clinicians and researchers have tried to identify predictors that indicate patients at risk of developing PSD. This also includes the research question whether there is an association between PSD and stroke lesion characteristics, e.g., lesion size and lesion location. Early studies addressing this question are largely limited by technical constraints and, thus, focused on simple lesion characteristics such as lesion side or proximity of the lesion to the frontal pole of the brain. More recent studies have addressed the impact of involvement of specific neuronal circuits in the stroke lesion. State-of-the-art methods of lesion symptom mapping to study PSD have only been applied to small patient samples. Overall, results are controversial and no clear pattern of stroke lesions associated with PSD has emerged, though there are findings suggesting that more frontal stroke lesions are associated with higher incidence of PSD. Available studies are hampered by methodological limitations, including drawbacks of lesion analysis methods, small sample size, and the issue of patient selection. These limitations together with differences in approaches to assess PSD and in methods of image analysis limit the comparability of results from different studies. To summarize, as of today no definite association between lesion location and PSD can be ascertained and the understanding of PSD rests incomplete. Further insights are expected from the use of modern lesion inference analysis methods in larger patient samples taking into account standardized assessment of possible confounding parameters, such as stroke treatment and reperfusion status.

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“…Therefore, this method is able to capture the graded degree of impairment often seen following brain injury. This technique has been used in stroke patients to study language functions ( Fridriksson et al, 2016 , Mirman et al, 2015 , Dronkers et al, 2004 ), including speech fluency ( Bates et al, 2003 ), speech comprehension ( Bates et al, 2003 , Dronkers et al, 2004 ), and speech production ( Borovsky et al, 2007 , Basilakos et al, 2015 , Fridriksson et al, 2010 ), as well as other behavioral impairments such as post-stroke swallowing difficulties ( Galovic et al, 2017 ), somatosensory deficits ( Meyer et al, 2016 , Preusser et al, 2015 ), high level perceptual deficits ( Karnath et al, 2004 ), and even depression ( Kim et al, 2017 ), among others. A summary of the techniques involved in VLSM is presented in Fig.…”

Section: Voxel-based Lesion-symptom Mapping (Vlsm)mentioning

confidence: 99%

Connectome-based lesion-symptom mapping (CLSM): A novel approach to map neurological function

Gleichgerrcht

Fridriksson

Rorden

et al. 2017

NeuroImage: Clinical

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Lesion-symptom mapping is a key tool in understanding the relationship between structure and function in neuroscience as it can provide objective evidence about which regions are crucial for a given process. Initial limitations with this approach were largely overcome by voxel-based lesion-symptom mapping (VLSM), a method introduced in the early 2000s, which allows for a whole-brain approach to study the association between damaged areas and behavioral impairment by applying an independent statistical test at every voxel. By doing so, this technique eliminated the need to predefine regions of interest or classify patients into groups based on arbitrary cutoff scores. VLSM has nonetheless its own limitations; chiefly, a bias towards recognizing cortical necrosis/gliosis but with poor sensitivity for detecting injury along long white matter tracts, thus ignoring cortical disconnection, which can per se lead to behavioral impairment. Here, we propose a complementary method that, instead, establishes a statistical relationship between the strength of connections between all brain regions of the brain (as defined by a standard brain atlas) and the array of behavioral performance seen in patients with brain injury: connectome-based lesion-symptom mapping (CLSM). Whole-brain CLSM therefore has the potential to identify key connections for behavior independently of a priori assumptions with applicability across a broad spectrum of neurological and psychiatric diseases. We propose that this approach can further our understanding of brain-structure relationships and is worth exploring in clinical and theoretical contexts.

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Voxel-based lesion symptom mapping analysis of depressive mood in patients with isolated cerebellar stroke: A pilot study

Cited by 25 publications

References 58 publications

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

Post-Stroke Depression: Impact of Lesion Location and Methodological Limitations—A Topical Review

Connectome-based lesion-symptom mapping (CLSM): A novel approach to map neurological function

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