Voxel-based analysis of the diffusion tensor

Abe, Osamu; Takao, Hidemasa; Gonoi, Wataru; Sasaki, Hiroki; Murakami, Masaya; Kabasawa, Hiroyuki; Kawaguchi, Hiroshi; Goto, Masayoshi; Yamada, Hideaki; Yamasue, Hidenori; Kasai, Kiyoto; Aoki, Shigeki; Ohtomo, Kuni

doi:10.1007/s00234-010-0716-3

Cited by 60 publications

(44 citation statements)

References 57 publications

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“…FreeSurfer also provides the labels and statistical analysis of the segmented subcortical structures (Abe et al, 2010;Fischl et al, 2002;Fischl et al, 2004). Figure 2 shows the seven FreeSurfersegment subcortical structures discussed herein: i.e., the cerebellum, thalamus, caudate, putamen, pallidum, hippocampus, and amygdala.…”

Section: Imagingmentioning

confidence: 99%

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Sex differences in cortical and subcortical human brain anatomy

Herron¹,

Kang

Woods

2015

F1000Res

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Previous research has reported many sex differences in cortical and subcortical anatomy, but only a subset of findings is consistent across studies. Here, we used improved Freesurfer-based automated methods to analyze the properties of the cortex and seven subcortical structures in young, right-handed subjects (69 male and 69 female), carefully matched in age and education. Significant sex differences were observed. Females had greater gyral complexity (i.e., greater bending energy). In contrast, males had greater unadjusted cortical surface area (+10.3%), but area differences were reduced (to +2.8%) when area was adjusted for total intracranial volume (ICV). There were no significant omnibus sex differences in cortical thickness. Males showed larger unadjusted subcortical gray matter structural volumes, as well as larger ICV-adjusted volumes in the amygdala. These results help to resolve some of the inconsistencies in previous studies of sex differences in brain anatomy.

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Section: Imagingmentioning

confidence: 99%

“…Significant results in boldface. et al, 2010;Barta & Dazzan, 2003;Ronan et al, 2006;Salat et al, 2004). When we adjust overall cortical surface area for ICV, males had modest but significantly greater surface area, particularly in the frontal lobe.…”

Section: Cortical Sex Differencesmentioning

confidence: 99%

Sex differences in cortical and subcortical human brain anatomy

Herron¹,

Kang

Woods

2015

F1000Res

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“…Two of the most common causes of false positive results are minor misregistrations between treated and control groups, and failure to correct for multiple comparisons. 48,49 In this study, we have taken a number of steps to ensure accurate registration including the use of: (1) high-resolution, high-SNR diffusion-weighted images, (2) an unbiased MDT registration strategy, and (3) registration software specifically optimized for small animal image data. To correct for any residual misregistrations, images were spatially smoothed with a three-voxel 3D Gaussian kernel consistent with general guidelines for voxelwise analysis.…”

Section: Pitfalls Of Voxelwise Analysismentioning

confidence: 99%

Diffusion Tensor Imaging Reveals White Matter Injury in a Rat Model of Repetitive Blast-Induced Traumatic Brain Injury

CalabreseEvan

DuFu

GarmanRobert

et al. 2014

Journal of Neurotrauma

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Blast-induced traumatic brain injury (bTBI) is one of the most common combat-related injuries seen in U.S. military personnel, yet relatively little is known about the underlying mechanisms of injury. In particular, the effects of the primary blast pressure wave are poorly understood. Animal models have proven invaluable for the study of primary bTBI, because it rarely occurs in isolation in human subjects. Even less is known about the effects of repeated primary blast wave exposure, but existing data suggest cumulative increases in brain damage with a second blast. MRI and, in particular, diffusion tensor imaging (DTI), have become important tools for assessing bTBI in both clinical and preclinical settings. Computational statistical methods such as voxelwise analysis have shown promise in localizing and quantifying bTBI throughout the brain. In this study, we use voxelwise analysis of DTI to quantify white matter injury in a rat model of repetitive primary blast exposure. Our results show a significant increase in microstructural damage with a second blast exposure, suggesting that primary bTBI may sensitize the brain to subsequent injury.

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“…In an effort to better understand the pathophysiology of MDD and develop more effective treatments, much research has focused on delineating the structure and function of this mood regulation network. Although many studies have focused on the function of the network (Drevets et al, 2008b;Hafeman et al, 2012;Mayberg, 2003a, b;Murray et al, 2011;Phillips, 2006), including functional connectivity between key brain regions (Craddock et al, , 2012Greicius, 2008Greicius, , 2007James et al, 2009;Seminowicz et al, 2004;Sheline et al, 2010), others have focused on the structural connectivity of the network, ie, the white matter (WM) pathways between brain regions (Abe et al, 2010;Blood et al, 2010;Cole et al, 2012;Cullen et al, 2010;Kieseppa et al, 2010;Korgaonkar et al, 2011;Ma et al, 2007;Tha et al, 2013;Wu et al, 2011;Zhu et al, 2011;Zou et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous DTI studies have looked for WM integrity differences in patients with MDD (Abe et al, 2010;Blood et al, 2010;Cole et al, 2012;Cullen et al, 2010;Kieseppa et al, 2010;Korgaonkar et al, 2011;Ma et al, 2007;Tha et al, 2013;Wu et al, 2011;Zhu et al, 2011;Zou et al, 2008). However, the findings have been highly variable with respect to the location and direction of the difference in FA (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Reconciling Variable Findings of White Matter Integrity in Major Depressive Disorder

Choi

Holtzheimer

Franco

et al. 2013

Neuropsychopharmacol

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Diffusion tensor imaging (DTI) has been used to evaluate white matter (WM) integrity in major depressive disorder (MDD), with several studies reporting differences between depressed patients and controls. However, these findings are variable and taken from relatively small studies often using suboptimal analytic approaches. The presented DTI study examined WM integrity in large samples of medication-free MDD patients (n ¼ 134) and healthy controls (n ¼ 54) using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) approaches, and rigorous statistical thresholds. Compared with health control subjects, MDD patients show no significant differences in fractional anisotropy, radial diffusivity, mean diffusivity, and axonal diffusivity with either the VBM or the TBSS approach. Our findings suggest that disrupted WM integrity does not have a major role in the neurobiology of MDD in this relatively large study using optimal imaging acquisition and analysis; however, this does not eliminate the possibility that certain patient subgroups show WM disruption associated with depression.

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Voxel-based analysis of the diffusion tensor

Abstract: The discrepancy among these results was not explained in full, but possible explanations were misregistration and smoothing for the SPM-based methods and insensitivity to FA changes outside the local centers of white matter bundles for TBSS-based method.

Cited by 60 publications

References 57 publications

Sex differences in cortical and subcortical human brain anatomy

Sex differences in cortical and subcortical human brain anatomy

Diffusion Tensor Imaging Reveals White Matter Injury in a Rat Model of Repetitive Blast-Induced Traumatic Brain Injury

Reconciling Variable Findings of White Matter Integrity in Major Depressive Disorder

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