A main cable of a long-span suspension bridge is semi-surrounded by a catwalk during construction. Thus, design parameters of a catwalk may have influences on the galloping stability of a main cable during construction. To study the influence of catwalk design parameters on the galloping of steepled main cables, two main foci have been conducted. Firstly, the aerodynamic coefficients of the catwalk with actual design parameters are obtained by numerical simulation based on computational fluid dynamics (CFD), and the numerical results are compared with those of the previous wind tunnel test. Several typical main cables with different cross sections of a long-span suspension bridge during construction are selected, and their Den Hartog coefficients are obtained based on the numerical simulation considering the aerodynamic influences of the catwalks. Then four typical working conditions of a main cable which have great potential to occur galloping are selected based on the galloping analyze, and their aerodynamic coefficients considering the influence of the catwalk with different design parameters are obtained. The influence of the catwalk design parameters on galloping of the main cables is analyzed based on the Den Hartog criterion. Results indicate that catwalk design parameters have evident influences on aerodynamic coefficients and galloping of the main cables. The parameters of the catwalk which are favorable for suppressing the galloping of the main cables are determined, which establish a good guideline for the galloping-resistant design of the catwalk-main cable system on suspension bridges.