Multi-field coupling problems are taken more and more attention mainly because of the higher requirement of load, efficiency, and reliability in aero-engine operation. This research takes an aero-engine compressor as the research object, 3D flow field and structural models are established. For the method of cyclic symmetric, single-sector model is selected as the calculation domain. Considering the influence of former stator wakes, compressor flow field is simulated. The article analyzes the distribution law of unsteady aerodynamic load on rotor blade. Based on Kriging model, load transfer of aerodynamic pressure and temperature is achieved from flow field to blade structure. Then the effects of centrifugal force, aerodynamic pressure and temperature load are discussed on compressor vibration characteristic and structural strength. The results show dominant fluctuation frequencies of aerodynamic load on rotor blade are manly at frequency doubling of stator-rotor interaction, especially at one time frequency (1 Â f 0 ). Magnitude and pulsation amplitude on pressure surface are far greater than that on suction surface. Load transfer with Kriging model has a higher precision, it can meet the requirement of multi-field coupling dynamic calculation. In multi-field coupling interaction, temperature load makes the natural vibration frequencies decrease obviously, centrifugal force is the main source of deformation and stress. Bending stress induced by aerodynamic pressure and temperature load can counteract part of bending stress induced by centrifugal force. However, temperature load causes the maximum displacement of blade-disk system to increase.