Vortex-Assisted Dispersive Molecularly Imprinted Polymer-Based Solid Phase Extraction of Acetaminophen from Water Samples Prior to HPLC-DAD Determination

Abstract

In the present study, acetaminophen (ACT) molecularly imprinted polymer (ACT-MIP) were successfully synthesized via surface imprinting polymerization. The structural and morphological properties of ACT-MIP were characterized using various analytical techniques. ACT-MIP were used as an adsorbent in a vortex-assisted dispersive molecularly imprinted solid-phase micro-extraction (VA-d-μ-MISPE), coupled with a high-performance liquid chromatography–diode array detector (HPLC-DAD) method for the determination of ACT in water samples. Influential parameters such as the mass of adsorbent, vortex speed, extraction time, desorption volume, and desorption time were optimized using a multivariate approach. Under optimum conditions, the maximum binding capacities of ACT-MIP and NIP (non-imprinted polymers) were 191 mg/g and 71.5 mg/g, respectively. The linearity was attained across concentrations ranging from 0.630 to 500 µg/L, with a coefficient of determination of 0.9959. For ACT-MIP, the limit of detection (LOD) and limit of quantification (LOQ), enhancement factor, and precision of the method were 0.19 ng/L, 0.63 ng/L, 79, and <5%, respectively. The method was applied in the analysis of spiked water samples, and satisfactory percentage recoveries in the range of 95.3–99.8% were obtained.

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

“…To eliminate any possible error, due to residual Saxa retained on the electrode' surface, in between differential pulse voltammetric (DPV) measurements, the electrode was soaked in 5 % ethanol for 5 min while stirring followed by rinsing with milli Q water. The NIP modified CPEs were made using the same process, while using NIP instead of MIP [29,31].…”

“…MIPs have found vast applications in the fields of solid phase extraction of natural products [28–33], environmental applications [34–36] and as carriers for drug delivery [37–41]. Also, MIPs were reported to be excellent modifiers in electrochemical sensors designed for different analytes including: pharmaceutical compounds [42–45], metal ions [46, 47] and biological molecules as virus [48, 49], bacteria [50, 51] and proteins [52, 53].…”

“…MIPs have found vast applications in the fields of solid phase extraction of natural products [28][29][30][31][32][33], environmental applications [34][35][36] and as carriers for drug delivery [37][38][39][40][41]. Also, MIPs were reported to be…”

Molecularly Imprinted Polymers: Selective Extraction Materials for Sample Preparation

“…As mentioned above, MIPs can be incorporated into other sample-preparation microextraction techniques. For example, the incorporation of MIPs to Dispersive (Micro)Solid Phase Extraction (D-µ-SPE) has received special attention in recent years, and it is reflected in this Special Issue in the comprehensive review by Thilini Madurangika Jayasinghe and Moreda-Piñeiro [13] and in the article by Mpayipheli et al [14] devoted to the develop-ment of a Vortex-Assisted Dispersive Molecularly Imprinted Polymer-Based Solid Phase Extraction method for the determination of acetaminophen from water samples.…”

Nanocomposite membranes for the removal of dyes

“…As a result, a substantial number of adsorbent materials with attractive characteristics have been used in the above-mentioned analytical sample preparation methods. These include molecularly imprinted polymers [52,53], porous organic polymers [54], covalent organic frameworks [55,56], zeolites [57], layered double hydroxide [58], carbon nanomaterials [59,60], and MOFs [11,48,61,62], among others. The application of MOFs as adsorbents in various solid phase-based extraction methods has recently emerged due to their remarkable properties.…”