von Willebrand's disease and psychotic disorders: co‐segregation and genetic associations

Lee, Yu-Sang; Miller, Mary M.; Hassett, Andrea Cortese; Lee-Kim, Byung-Yeon; Kim, Jung Jin; Haracznak, Michelle; Ranade, Swati; Wood, Joel; Reddy, Ravinder; Kupfer, David J.; Bontempo, Franklin A.; Nimgaonkar, Vishwajit L.

doi:10.1111/j.1399-5618.2004.00103.x

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…S100A11 has been observed to be overexpressed in colorectal, gastric, prostrate and pancreatic cancers [35]. Previous work by us and others have shown an increase in expression of S100A8, S100A9 and S100A10 in mouse or rat brain in response to chronic treatment with antidepressants and olanzapine [7,36,37]. Future studies are needed to determine whether the changes in S100a11 gene expression observed in rat frontal cortex are medication effects or markers of inflammation.…”

Section: Additional Genes Down-regulated By Lithiummentioning

confidence: 84%

The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder

Fatemi

Reutiman

Folsom

2009

Biochemical Society Transactions

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Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4-4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy in the treatment of bipolar disorder, but their molecular targets and mode of action are largely unknown. A few studies have begun to shed light on potential targets of lithium treatment that may be involved in lithium's therapeutic effect. We have recently conducted a microarray study of rat frontal cortex following chronic treatment (21 days) with lithium. Chronic treatment with lithium led to a significant (at least 1.5-fold) down-regulation of 151 genes and up-regulation of 57 genes. We discuss our results in the context of previous microarray studies involving lithium and gene-association studies to identify key genes associated with chronic lithium treatment. A number of genes associated with bipolar disorder, including Comt (catechol-O-methyltransferase), Vapa (vesicle-associated membrane protein-associated protein A), Dtnb (dystrobrevin beta) and Pkd1 (polycystic kidney disease 1), were significantly altered in our microarray dataset along with genes associated with synaptic transmission, apoptosis and transport among other functions.

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Section: Additional Genes Down-regulated By Lithiummentioning

confidence: 84%

The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder

Fatemi

Reutiman

Folsom

2009

Biochemical Society Transactions

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“…In the control group, an increase in the number of major alleles of rs11846959 was significantly associated with a decrease in expression of the AAT protein. Finally, vWF polymorphisms have also been implicated in schizophrenia and bipolar disorder but only in studies investigating co-segregation and genetic associations between von Willebrand’s disease and psychotic disorders 49 . We found that a higher number of major alleles of rs12829220 was significantly associated with an increasing level of the vWF in controls (Table 3 , Fig.…”

Section: Discussionmentioning

confidence: 99%

Associations between SNPs and immune-related circulating proteins in schizophrenia

Chan

Cooper

Frank

et al. 2017

Sci Rep

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Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia. However, despite the convergence of evidence, direct links between the genetic and proteomic findings are still lacking for schizophrenia. We investigated associations between single nucleotide polymorphisms (SNPs) from the custom-made PsychArray and the expression levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 matched controls. We identified associations between 81 SNPs and 29 proteins, primarily involved in immune/inflammation responses. Significant SNPxDiagnosis interactions were identified for eight serum proteins including Factor-VII[rs555212], Alpha-1-Antitrypsin[rs11846959], Interferon-Gamma Induced Protein 10[rs4256246] and von-Willebrand-Factor[rs12829220] in the control group; Chromogranin-A[rs9658644], Cystatin-C[rs2424577] and Vitamin K-Dependent Protein S[rs6123] in the schizophrenia group; Interleukin-6 receptor[rs7553796] in both the control and schizophrenia groups. These results suggested that the effect of these SNPs on expression of the respective proteins varies with diagnosis. The combination of patient-specific genetic information with blood biomarker data opens a novel approach to investigate disease mechanisms in schizophrenia and other psychiatric disorders. Our findings not only suggest that blood protein expression is influenced by polymorphisms in the corresponding gene, but also that the effect of certain SNPs on expression of proteins can vary with diagnosis.

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“…To the best of our knowledge, no article (in English) has been published regarding levels of vWF, a reliable marker of endothelial cell activation, in schizophrenia or bipolar disorder. One study of psychotic disorders reported association and genetic linkage between bipolar I disorder and the vWF gene (37). Our findings in the current study of elevated levels of vWf suggest that endothelial cell activation is of importance in both schizophrenia and bipolar disorder, consistent with new findings of endothelial dysfunction in schizophrenia (38).…”

Section: Discussionmentioning

confidence: 99%

Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor

et al. 2009

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von Willebrand's disease and psychotic disorders: co‐segregation and genetic associations

Abstract: These studies are consistent with association and linkage between vWF and BD I. However, given the relatively small sample, stochastic variation is an alternative explanation.

Cited by 4 publications

References 24 publications

The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder

The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder

Associations between SNPs and immune-related circulating proteins in schizophrenia

Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor

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