Abstract:esraa ismaiL , ‡ Xuanhong cheng , ‡ guruprasaD a. giriDharan , § anD paLaniappan seThu * † Nonsurgical bleeding occurs in a significant proportion of patients implanted with continuous-flow ventricular assist devices (CF-VADs) and is associated with nonphysiologic flow with diminished pulsatility. An in vitro vascular pulse perfusion model seeded with adult human aortic endothelial cells (HAECs) was used to identify biomarkers sensitive to changes in pulsatility. Diminished pulsatility resulted in an ~45% decr… Show more
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