Von Meyenburg complex clinically presenting as metastatic liver nodule: A rare finding in an elderly male

Shirazi, Nadia; Chauhan, Neena; Chandra, Smita; Kumar, Sunil Saini

doi:10.4103/jlp.jlp_55_19

Cited by 7 publications

(7 citation statements)

References 5 publications

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“…Abnormal development of the portal tract, including the bile duct, is the primary cause of MHL. Moreover, progression from bile duct hamartoma to iCCA has been reported in previous studies [11,12]. Although the mechanism and histopathological association between MHL and bile duct hamartoma have not been uncovered since both hamartomas include bile duct structures, iCCA should be considered in the differential diagnosis when malignant transformation of MHL is suspected.…”

Section: Discussionmentioning

confidence: 84%

Progression of a persisting mesenchymal hamartoma to intrahepatic cholangiocarcinoma 24 years after the initial diagnosis: A case report

Gang

Choi

Lee

et al. 2022

Ann Hepatobiliary Pancreat Surg

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Mesenchymal hamartoma of the liver (MHL) is a rare benign tumor that often presents in early childhood, and it rarely occurs in adulthood. Aberrant development of the portal tract is a known cause of MHL. Although limited information is available on the natural course of MHL, malignant transformation has been reported in a few cases. Here, we report a case of a 26-year-old female with intrahepatic cholangiocarcinoma secondary to unresected MHL. The patient underwent resection of the hepatic mass, which was diagnosed as MHL at 2 years of age, due to an increase in mass size and a suspicion of malignant transformation during work-up. Histopathology confirmed intrahepatic adenosquamous carcinoma in the background of MHL, with a T2N0M0 pathological stage (stage II). The surgical margin was free from tumor cells. The patient fully recovered postoperatively and started receiving adjuvant chemotherapy. Previous case reports have only reported about the development of undifferentiated embryonal sarcoma or angiosarcoma as malignant transformation of MHL. Cases of other malignancies have not been published; however, it is difficult to rule out the occurrence of various malignancies related to the portal tract when considering the pathogenesis of the disease. To the best of our knowledge, this is the first case report of adenocarcinoma of bile duct origin secondary to MHL. This case report suggests that aggressive surgical management should be considered after the initial diagnosis of MHL.

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Section: Discussionmentioning

confidence: 84%

Progression of a persisting mesenchymal hamartoma to intrahepatic cholangiocarcinoma 24 years after the initial diagnosis: A case report

Gang

Choi

Lee

et al. 2022

Ann Hepatobiliary Pancreat Surg

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“…Klasyfikowany jest jako wrodzone, nienowotworowe zaburzenie rozwojowe dróg żółciowych typu hamartoma [1,2,3]. Często współistnieje z innymi wrodzonymi chorobami wątroby (wrodzone włóknienie wątroby, wielotorbielowatość nerek dziedziczona autosomalnie dominująco, choroba Caroliego) [4,5]. Częstość występowania zależy od wieku -w populacji dorosłych na podstawie dużej serii materiałów sekcyjnych wynosi 5,6%, u dzieci 0,9% [4,5,6].…”

Section: Wprowadzenieunclassified

“…Często współistnieje z innymi wrodzonymi chorobami wątroby (wrodzone włóknienie wątroby, wielotorbielowatość nerek dziedziczona autosomalnie dominująco, choroba Caroliego) [4,5]. Częstość występowania zależy od wieku -w populacji dorosłych na podstawie dużej serii materiałów sekcyjnych wynosi 5,6%, u dzieci 0,9% [4,5,6]. Makroskopowo są to rozrzucone w wątrobie liczne, rzadziej pojedyncze guzki, zlokalizowane pod torebką Glissona.…”

Section: Wprowadzenieunclassified

“…Według Singhal i wsp. złotym standardem w diagnostyce tych rzadkich zmian jest wykonanie biopsji wątroby [5,11].…”

Section: Dyskusjaunclassified

“…chorzy z dolegliwościami spowodowanymi dużymi rozmiarami torbieli lub ze znacznym upośledzeniem pracy wątroby powinni być poddani leczeniu. Proponuje stosowanie drenażu przezskórnego z skleroterapią, resekcję chirurgiczną lub marsupializację oraz leczenie objawowe [5]. Odradza się rutynowe stosowanie markera CA-19-9 do diagnozowania transformacji nowotworowej.…”

Section: Dyskusjaunclassified

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Von Meyenburg complexes in a patient with chronic gastritis - a case report

Brodowski

Pawłowski

Borowik

et al. 2022

J Educ Health Sport

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Introduction: Bile ducts hamartoma (von Meyenburg complexes) is a common but unknown pathology of the liver. It can lead to the widening of the bile ducts. It is usually detected incidentally in asymptomatic patients. There are indications of transformation into bile duct cancer or hepatocellular carcinoma.Aim of the study: The aim of the study is to draw attention to a little known, but common pathology - von Meyenburg complexes and to sensitize medical professionals to the implications it may cause during the diagnostic process.Material and methods: We conducted a case study. The research material was the patient's medical history.Case report: A 60-year-old man came to the Gastrology Clinic due to chronic epigastric pain and tenderness in the navel area. Colonoscopy ruled out pathology in the large intestine. After six months, the pain worsened. The result of the gastroscopy allowed the diagnosis of chronic gastritis, which was probably the cause of the problem. The abdominal ultrasound showed a suspicion of renal cell carcinoma of the right kidney, but the neoplastic process was excluded on the basis of the abdominal computed tomography. In the same study, for the first time, numerous minor hypodense lesions in the liver were detected. The final diagnosis was made on the basis of magnetic resonance cholangiography, where the disseminated, T2 hyperintense cystic areas were described. This suggested a biliary scythe.Conclusions: Despite the asymptomatic occurrence of biliary hamartoma, it is important to remember about the possible transformation into a malignant neoplasm. It should be considered in the differential diagnosis of disseminated liver lesions. Patients should be treated symptomatically.

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Developmental, Familial, and Metabolic Disorders

Kanel

2024

Atlas of Liver Pathology

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Von Meyenburg complex clinically presenting as metastatic liver nodule: A rare finding in an elderly male

Cited by 7 publications

References 5 publications

Progression of a persisting mesenchymal hamartoma to intrahepatic cholangiocarcinoma 24 years after the initial diagnosis: A case report

Progression of a persisting mesenchymal hamartoma to intrahepatic cholangiocarcinoma 24 years after the initial diagnosis: A case report

Von Meyenburg complexes in a patient with chronic gastritis - a case report

Developmental, Familial, and Metabolic Disorders

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