Vomiting and diarrhea in a woman with systemic lupus erythematosus

Liao, Wei‐Chih; Yaun, Wei-Hsin; Su, Chien–Wei; Hou, Ming‐Chih; H, Lin; Lee, Fa-Yauh

doi:10.1016/j.jcma.2014.06.012

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The majority of the patients have mild symptoms, and life-threatening complications are rare. Common gastroenterological manifestations are pancreatitis, protein-losing enteropathy, acalculous cholecystitis, vasculitis, diarrhea, and ascites [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Protein-Losing Enteropathy as the First Presentation of Systemic Lupus Erythematosus in a Resource-Limited Setting in Sri Lanka: A Case Report

Ramesh¹,

Suganthan²,

Selvaratnam³

et al. 2023

Cureus

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Protein-losing enteropathy (PLE) is one of the rare gastrointestinal manifestations of systemic lupus erythematosus (SLE), which can manifest several years before the diagnosis of SLE. PLE should be suspected in patients with hypoalbuminemia in the absence of urinary protein loss and normal liver functions without any other manifestations of malnutrition. Due to the non-specificity of the imaging and histological findings, it is difficult to diagnose PLE in resource-limited settings. Thus, it is underdiagnosed. We report the case of a 38-year-old Sri Lankan (South Asian) female who is a diagnosed patient with hypothyroidism and has presented with worsening generalized body swelling and ascites for two months. She had hypoalbuminemia without proteinuria. Thus, the clinical diagnosis of PLE was suspected. The diagnosis of SLE was suspected because of significant alopecia, high titer (1:1000) antinuclear antibody (ANA) positivity, and hypocomplementemia. Though confirmatory tests such as Tc-99 albumin scintigraphy and stool alpha-1 anti-trypsin were not available in our resource-limited setting, the diagnosis of the SLE-associated proteinlosing enteropathy was made as the patient fulfilled the European Alliance of Associations for Rheumatology (EULAR) criteria for SLE and also by excluding all the other possible causes of PLE.

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Section: Introductionmentioning

confidence: 99%

Protein-Losing Enteropathy as the First Presentation of Systemic Lupus Erythematosus in a Resource-Limited Setting in Sri Lanka: A Case Report

Ramesh¹,

Suganthan²,

Selvaratnam³

et al. 2023

Cureus

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“…To diagnose LE in SLE patients clinically, abdominal computed tomography (CT), angiography, gastrointestinal endoscopy, and abdominal ultrasound are commonly used [14] , [15] , [16] . Abdominal CT is useful in diagnosing LE [10] .…”

Section: Introductionmentioning

confidence: 99%

A nomogram to predict the risk of lupus enteritis in systemic lupus erythematosus patients with gastroinctestinal involvement

et al. 2021

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Background: Lupus enteritis (LE), a main cause of acute abdominal pain in systemic lupus erythematosus (SLE) patients, is a serious and potentially fatal complication. This study aimed to identify clinical serological indicators to establish a nomogram to assess LE in SLE patients with gastrointestinal manifestations. Methods: The clinical and laboratory data of SLE patients with gastrointestinal manifestations that were hospitalized in the West China Hospital from January 2010 to January 2020 were retrospectively analyzed. The least absolute shrinkage and selection operator logistic regression model was used to select potentially relevant features. Subsequently, a nomogram was developed using multivariable logistic analysis. The performance of the nomogram was evaluated using a receiver operating characteristic curve, a calibration curve, and decision curve analysis (DCA). Findings: We included a total of 8,505 SLE patients, of which 251 had experienced gastrointestinal manifestations. The patients were randomly divided into training (n = 176) and validation (n = 75) groups. The LRA (LE Risk Assessment) model consisted of 11 significantly associated variables, which included complement 4, antineutrophil cytoplasmic antibody, albumin, anion gap, age, D-dimer, platelet, serum chlorine, anti-Sj€ ogren's-syndrome-related antigen A, anti-ribosomal P protein, and anti-ribonucleoprotein. In the training and validation cohorts, the areas under the curve were 0.919 (95% confidence interval [CI]: 0.876À0.962) and 0.870 (95% CI: 0.775À0.964), respectively. The nomogram demonstrated excellent performance in the calibration curve and DCA. Interpretation: The LRA model exhibits good predictive ability in assessing LE risk in SLE patients with gastrointestinal manifestations.

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Gastrointestinal involvement in systemic lupus erythematosus: A systematic review

Frittoli

Vivaldo

Costallat

et al. 2021

Journal of Translational Autoimmunity

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Vomiting and diarrhea in a woman with systemic lupus erythematosus

Cited by 3 publications

References 5 publications

Protein-Losing Enteropathy as the First Presentation of Systemic Lupus Erythematosus in a Resource-Limited Setting in Sri Lanka: A Case Report

Protein-Losing Enteropathy as the First Presentation of Systemic Lupus Erythematosus in a Resource-Limited Setting in Sri Lanka: A Case Report

A nomogram to predict the risk of lupus enteritis in systemic lupus erythematosus patients with gastroinctestinal involvement

Gastrointestinal involvement in systemic lupus erythematosus: A systematic review

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