Volunteering, Subjective Sleep Quality, and Chronic Inflammation: A 5-Year Follow-Up of the National Social Life, Health, and Aging Project

Kim, Seoyoun; Yoon, Hyunwoo

doi:10.1177/0164027520922624

Cited by 10 publications

(6 citation statements)

References 51 publications

(74 reference statements)

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“…Second, inflammation is a key factor strongly associated with depression. The study reported that short sleep duration and insomnia symptoms were associated with increases in inflammatory cytokines such as CRP and IL6 [ 40 , 41 ]. Third, good sleep helps boost levels of melatonin [ 42 ], a molecule that regulates pleiotropic effects that reduce symptoms of depression [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Nocturnal Sleep Duration and Insomnia symptoms with depressive symptoms among 44,900 Chinese Han adults aged 30–79 in Southwest China

Gao¹,

Tang²,

Mao³

et al. 2023

BMC Psychiatry

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Background Although there are several cross-sectional and prospective studies on the relationship between sleep duration /insomnia symptoms and depression symptoms, the results of these studies are still not conclusive, and few studies have further analyzed the association between sleep duration and depressive symptoms in adults by gender and age. Thus, this study aimed to investigate the relationship between nocturnal sleep duration and insomnia symptoms with depression symptoms, and further examine whether the association was impacted by age and gender in a large-scale Han Chinese population in southwest China. Methods A cross-sectional study was performed that included 44,900 participants from 18 districts in southwest China from September 2018 to January 2019. The study comprised 42,242 individuals in the final analysis. Depressive symptoms were investigated using the PHQ-2 questionnaires. Multivariate logistic regression analysis was performed to investigate the relationship between nocturnal sleep duration and insomnia symptoms with depression symptoms as well as the influence of age and gender. Results After adjusting for multiple variables, those with nocturnal sleep duration < 7 h had a higher odds ratio for depression (OR:1.47, 95%CI 1.31–1.65) compared to participants whose nocturnal sleep duration was in the range of 7-8 h. Notably, there is a higher association in those aged below 45 years (OR:1.91, 95%CI 1.52–2.41) and in female participants (OR:1.57, 95%CI 1.35–1.82). However, nocturnal sleep duration longer than 9 h was not associated with depression symptoms in either the whole population analysis or the subgroup analysis. Insomniacs had a higher odds ratio for depression(OR:1.87, 95%CI 1.84–2.36, respectively) compared to non-insomniacs. There is a higher association in those aged 45–60 years (OR:2.23, 95%CI 1.82–2.73) and in female participants (OR:2.17, 95%CI 1.84–2.56). Further subgroup analysis by age and gender at the same time showed the association between sleep deprivation and depression was highest among women aged below 45 years, while the association between insomnia and depression was the highest among men aged 45–59 years. Conclusion Short nocturnal sleep duration and insomnia symptoms were positively associated with the risk of depressive symptoms among Chinese Han adults aged 30–79 in Southwest China, especially the middle-aged population and females should be more concerned.

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Section: Discussionmentioning

confidence: 99%

Association between Nocturnal Sleep Duration and Insomnia symptoms with depressive symptoms among 44,900 Chinese Han adults aged 30–79 in Southwest China

Gao¹,

Tang²,

Mao³

et al. 2023

BMC Psychiatry

View full text Add to dashboard Cite

show abstract

“…First, a major explanation is inflammation, a key factor strongly associated with depression [ 33 ]. Studies have reported both short and long sleep durations and poor sleep quality to be associated with increased inflammatory cytokines such as CRP and IL6 [ 34 – 36 ]. Second, good sleep quality could help increase levels of melatonin [ 37 ], a pleiotropic regulator molecule that has been reported to alleviate depressive symptoms [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

The association of sleep duration and quality with depressive symptoms in older Chinese women

et al. 2022

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Poor sleep quality or short and long sleep duration are associated with many negative health outcomes, such as diabetes, hypertension, and fatigue, which may directly or indirectly correlate with poor mental health. Although, the association between sleep duration and quality, and depressive symptoms has been examined, the results of these studies were inconsistent and evidence specifically on older women is lacking. Therefore, we designed a cross-sectional study to evaluate the association between sleep duration and quality, and depressive symptoms in a relatively large sample of older Chinese women. The data were collected from 1,429 older women aged ≥60 years during bone-health examinations in Shanghai. Information on sleep duration and quality were assessed using a self-reported questionnaire. Depressive symptoms were assessed using the Zung self-rating depression scale (SDS), and depressive symptoms were considered present for SDS scores ≥ 45. Logistic regression models were used to analyze the association between sleep and depressive symptoms. After adjusting for all potential confounding factors, a J-shaped association was found between sleep duration and depressive symptoms. When a sleep duration of 6–8 hours was set as a reference, the odds ratios and 95% confidential intervals of short and long sleep duration were 1.31 (0.99, 1.73) and 2.10 (1.40, 3.16), respectively. Moreover, sleep quality was inversely associated with the prevalence of depressive symptoms (p for trend = 0.040). When the SDS cut-off score defining depressive symptoms was changed to 40 and 50, these associations were somewhat weakened, but the trend did not change. This study replicated and extended prior research findings that sleep duration and quality may influence mental health in older women.

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“…It has been suggested that poor sleep quality may lead to a series of changes in hormonal, metabolic, and inflammatory status of the people. For example, insomnia has been related with insulin resistance, activated inflammatory response, and enhanced systematic oxidative stress (Hashemipour, Ghorbani, Khashayar, & Olfati, 2021 ; Irwin & Vitiello, 2019 ; Kim & Yoon, 2020 ), all of which may lead to protein synthesis impairment and sarcopenia, a major cause of physical frailty in the older (Cleasby, Jamieson, & Atherton, 2016 ; Umegaki, 2016 ). Studies are needed for further clarification of the mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Association between insomnia and frailty in older population: A meta‐analytic evaluation of the observational studies

et al. 2022

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Introduction:Poor sleep quality has been suggested as a risk factor of frailty. However, previous studies that evaluated the association between insomnia and frailty in older population showed inconsistent results. We performed a meta-analysis to comprehensively evaluate the association.Methods: Observational studies related to the aim of the meta-analysis were identified by search of PubMed, Embase, and Web of Science databases. A random-effect model incorporating the potential between-study heterogeneity was used to pool the results.Results: Twelve studies including 16,895 old people contributed to the meta-analysis.Pooled results suggested a significant association between insomnia and frailty in the older population (odds ratio [OR]: 1.95, 95% confidence interval [CI]: 1.52-2.41, p < .001; I 2 = 80%). Subgroup analyses showed consistent association between different symptoms of insomnia and frailty, including difficulty in falling asleep (OR: 1.45), difficulty in maintaining sleep (OR: 1.23), early morning awakening (OR: 1.21), and non-restorative sleep (OR: 1.84, p for subgroup difference = .15). Results were also consistent for subgroup analyses according to the study country, sample size, cutoffs of age for defining the older population, proportions of men, diagnostic criteria for frailty, adjustment of depression, and scores of study quality (p for subgroup difference all > .05). However, a stronger association was observed for insomnia detected with the Athens Insomnia Scale (OR: 2.92) than that with Pittsburgh Sleep Quality Index (OR: 1.30) or self-reporting (OR: 1.60, p for subgroup difference = .002). Conclusion:Insomnia is independently associated with frailty in the older population.

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Volunteering, Subjective Sleep Quality, and Chronic Inflammation: A 5-Year Follow-Up of the National Social Life, Health, and Aging Project

Cited by 10 publications

References 51 publications

Association between Nocturnal Sleep Duration and Insomnia symptoms with depressive symptoms among 44,900 Chinese Han adults aged 30–79 in Southwest China

Association between Nocturnal Sleep Duration and Insomnia symptoms with depressive symptoms among 44,900 Chinese Han adults aged 30–79 in Southwest China

The association of sleep duration and quality with depressive symptoms in older Chinese women

Association between insomnia and frailty in older population: A meta‐analytic evaluation of the observational studies

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