Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice

Abstract

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Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats

“…It is well known that physical exercise inhibits the activation of NF-κB signal caused by inflammation [22,23]. In particular, voluntary wheel exercise in rodents induces changes in several signaling molecules by inhibiting the stress-related behavior compared to forced exercise [24,25]. In the current study, voluntary wheel running reduced IκB-α phosphorylation, resulting in NF-κB inactivation.…”

Dos mundos conectados: Cómo la exposición al estrés social nos hace más vulnerables al consumo de drogas

“…Using the oral alcohol self-administration paradigm, an increase in consumption and motivation to obtain the substance have been observed in defeated animals. Moreover, this effect is maintained several months after the last social defeat (Reguilón et al, 2020). Similar results have been shown in mice subjected to social defeat during adolescence (Rodríguez-Arias et al, 2016).…”

“…Another critical time is during the rehabilitation process, where social stress can easily induce relapse. Preclinical studies support the outcomes observed in humans and show that exposure to social defeat increases alcohol intake compared to non-stressed animals (Reguilón et al, 2020). Using the oral alcohol self-administration paradigm, an increase in consumption and motivation to obtain the substance have been observed in defeated animals.…”

Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward

“…After SD, increases in the acquisition of and motivation to take cocaine has been extensively reported using the SA procedure [153][154][155][156]. Equally, defeated mice show higher ethanol intake in the oral SA paradigm [61,76,157,158]. Studies using the CPP paradigm have also shown an enhancement in the conditioned rewarding effects of cocaine and ethanol in stressed animals [73,[158][159][160][161].…”

“…Equally, defeated mice show higher ethanol intake in the oral SA paradigm [61,76,157,158]. Studies using the CPP paradigm have also shown an enhancement in the conditioned rewarding effects of cocaine and ethanol in stressed animals [73,[158][159][160][161]. Both the aforementioned paradigms permit a broad assessment of the rewarding effects of drugs of abuse as both measure the role of motivation and environmental cues [162,163].…”