Voluntary wheel running: a review and novel interpretation

Sherwin, CM

doi:10.1006/anbe.1998.0836

Cited by 419 publications

(333 citation statements)

References 169 publications

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“…However, time spent on wheel running after 2 weeks of exposure to the wheel and cage floor movement at baseline were not correlated (12-h average, Pearson correlation: r = 0.230, p = 0.317). Apparently, wheel running cannot be directly compared to other forms of locomotion, as was also concluded by others [24]. Thus, the higher baseline activity in DBA mice cannot explain why DBA mice were more sensitive to wheel running in the present study.…”

Section: Inbred Strain Differences In Wheel Runningmentioning

confidence: 46%

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Visser

Bos

Stoker

et al. 2007

Behavioural Brain Research

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Recent studies suggest running wheel activity to be naturally rewarding and reinforcing; considering the shared neuro-behavioural characteristics with drug-induced reward situations, wheel running behaviour gains interest as a tool to study mechanisms underlying reward-sensitivity. Previously, we showed that wheel running has the potential to disrupt the daily organization of home cage behaviour in female C57BL/6 [de Visser L, van den Bos R, Spruijt BM. Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion. Behav Brain Res 2005;160:382-8]. In the present study, we investigated the effects of novelty-induced stress on wheel running and its impact on home cage behaviour in male C57BL/6 and DBA/2 mice. Our aim was to determine whether wheel running may be used as a tool to study both genetic and environmentally induced differences in sensitivity to rewarding behaviour in mice. One group of male mice was placed in an automated home cage observation system for 2 weeks with a wheel integrated in the cage. A second group of mice was allowed to habituate to this cage for 1 week before a running wheel was introduced. Results showed a pronounced sensitising effect of novelty on the level of wheel running in C57Bl/6 mice but not in DBA mice. Overall levels of wheel running were higher in DBA/2 mice. Furthermore, wheel running affected circadian rhythmicity in DBA/2 mice but not in C57BL/6 mice.From these findings we tentatively suggest that wheel running behaviour could serve as a tool to study the interaction between genetic and environmental factors in sensitivity to rewarding behaviour in mice. As it is displayed spontaneously and easy to monitor, wheel running may be well suitable to be included in high-throughput phenotyping assays.

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Section: Inbred Strain Differences In Wheel Runningmentioning

confidence: 46%

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Visser

Bos

Stoker

et al. 2007

Behavioural Brain Research

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“…Finally, it is an extremely sensitive behavioral model. For example, it has been reported that changes in motor activity detected by running wheel were considerably greater compared to other testing apparatus (Sherwin, 1998).…”

Section: Voluntary Running As An Indicator Of Manganese-induced Toxicitymentioning

confidence: 95%

“…Unfortunately, MRI studies do not necessarily include a formal behavioral test and an assessment of potential toxic effects of manganese is usually limited to a rather subjective general observation of animal behavior in the home cage. In our study, we used a voluntary wheel running test, which is a relatively easy, but quantitative method for measuring rodents' physical activity in response to chemical or environmental stimuli (Sherwin, 1998). In addition to testing toxic effects of MnCl 2 , we used this behavioral test to map functional brain activity with MEMRI in naturally behaving and actively moving animals.…”

Section: Manganese-induced Motor Dysfunctionmentioning

confidence: 99%

“…Voluntary wheel running is a wildly used behavioral model for rodents and other experimental animals (Sherwin, 1998). In fact, it is the most common behavior performed by captive animals and usually occurs spontaneously within a few minutes of access to the wheel.…”

Section: Voluntary Running As An Indicator Of Manganese-induced Toxicitymentioning

confidence: 99%

“…For example, the aversive effects (e.g. pain) might determine levels of voluntary wheel running (Sherwin, 1998). Finally, it is an extremely sensitive behavioral model.…”

Section: Voluntary Running As An Indicator Of Manganese-induced Toxicitymentioning

confidence: 99%

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Mapping of functional brain activity in freely behaving rats during voluntary running using manganese-enhanced MRI: Implication for longitudinal studies

et al. 2010

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Magnetic resonance imaging (MRI) is widely used in basic and clinical research to map the structural and functional organization of the brain. An important need of MR research is for contrast agents that improve soft-tissue contrast, enable visualization of neuronal tracks, and enhance the capacity of MRI to provide functional information at different temporal scales. Unchelated manganese can be such an agent, and manganese-enhanced MRI (MEMRI) can potentially be an excellent technique for localization of brain activity (for review see Silva et al., 2004). Yet, the toxicity of manganese presents a major limitation for employing MEMRI in behavioral paradigms. We have tested systematically the voluntary wheel running behavior of rats after systemic application of MnCl 2 in a dose range of 16-80 mg/kg, which is commonly used in MEMRI studies. The results show a robust dose-dependent decrease in motor performance, which was accompanied by weight loss and decrease in food intake. The adverse effects lasted for up to 7 postinjection days. The lowest dose of MnCl 2 (16 mg/kg) produced minimal adverse effects, but was not sufficient for functional mapping. We have therefore evaluated an alternative method of manganese delivery via osmotic pumps, which provide a continuous and slow release of manganese. In contrast to a single systemic injection, the pump method did not produce any adverse locomotor effects, while achieving a cumulative concentration of manganese (80 mg/kg) sufficient for functional mapping. Thus, MEMRI with such an optimized manganese delivery that avoids toxic effects can be safely applied for longitudinal studies in behaving animals.

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Quantitative Genetics of Behavioral Phenotypes

Kostrzewa

Kas

2017

Handbook of Neurobehavioral Genetics and Phenotyping

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Voluntary wheel running: a review and novel interpretation

Cited by 419 publications

References 169 publications

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

Mapping of functional brain activity in freely behaving rats during voluntary running using manganese-enhanced MRI: Implication for longitudinal studies

Quantitative Genetics of Behavioral Phenotypes

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