Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression

Gobinath, Aarthi R.; Richardson, Robin; Chow, Carmen; Workman, Joanna L.; Lieblich, Stephanie E.; Barr, Alasdair M.; Galea, Liisa A.M.

doi:10.1016/j.neuropharm.2017.09.017

Cited by 48 publications

(31 citation statements)

References 65 publications

(69 reference statements)

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“…As mentioned above, previous research also shows that the hippocampus has a high degree of plasticity during pregnancy and the postpartum period [82; 83; 85; 224; 225], making it a likely region for the actions of these medications on the maternal brain. Indeed, postpartum SSRI treatment affects the maternal hippocampus by decreasing intermediate and increasing post-mitotic immature neurons in the SGZ and GCL of the dentate gyrus three weeks after giving birth [211] as well as a decrease in the density of immature neurons around the same period [217]. There appears to be a time course with regards to SSRI effects on neurogenesis in the maternal hippocampus, as others report that at weaning and one week after weaning postpartum SSRI treatment has no effect on the rates of cell proliferation [213] or the number of immature neurons in the dentate gyrus [191; 211; 213].…”

Section: Ssris Affect Maternal Neuroplasticity-mentioning

confidence: 99%

Serotonin and motherhood: From molecules to mood

Pawluski

Lonstein

2019

Frontiers in Neuroendocrinology

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Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain. Serotonin is also implicated in the pathophysiology of numerous affective disorders and likely plays an important role in the pathophysiology of maternal mental illness. Therefore, the main goals of this review are to detail: 1) how the serotonin system of the female brain changes across pregnancy and postpartum, 2) the role of the central serotonergic system in maternal caregiving and maternal aggression, and 3) how the serotonin system and selective serotonin reuptake inhibitor medications (SSRIs) are involved in the treatment of maternal mental illness. Although there is much work to be done, studying the central serotonin system's multifaceted role in the maternal brain is vital to our understanding of the processes governing matrescence and the maintenance of motherhood.

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Section: Ssris Affect Maternal Neuroplasticity-mentioning

confidence: 99%

Serotonin and motherhood: From molecules to mood

Pawluski

Lonstein

2019

Frontiers in Neuroendocrinology

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“…We have found that in a rodent model of postpartum depression, fluoxetine does not restore reduced levels of neurogenesis or increased levels of passive coping in the forced swim test at the end of the postpartum period (postpartum day 24, after 22 days of continual exposure to SSRI). Curiously however, we do see that fluoxetine can reverse maternal care deficits assessed in the early postpartum [71][72][73], suggesting that SSRIs may be effective in the early postpartum, but not in the late postpartum. Furthermore, Lonstein and colleagues [36,74,75] have noted changes in serotonin signalling during pregnancy and the postpartum, and these alterations likely influence the efficacy of SSRIs.…”

mentioning

confidence: 83%

“…Thus, it may not be surprising given that estradiol levels are decreased during the postpartum that selective serotonin reuptake inhibitors (SSRIs) may not be as efficacious during the postpartum. Certainly, studies in our laboratory have accumulated to suggest that efficacy of SSRIs such as fluoxetine and paroxetine are blunted during the late postpartum [71][72][73]. We have found that in a rodent model of postpartum depression, fluoxetine does not restore reduced levels of neurogenesis or increased levels of passive coping in the forced swim test at the end of the postpartum period (postpartum day 24, after 22 days of continual exposure to SSRI).…”

mentioning

confidence: 92%

“…Furthermore, Lonstein and colleagues [36,74,75] have noted changes in serotonin signalling during pregnancy and the postpartum, and these alterations likely influence the efficacy of SSRIs. More recently, we have found that exercise can be used in the postpartum as a viable option to increase neurogenesis and reduce immobility in the forced swim test with or without the addition of an SSRI [72]. It is not clear what may be interfering with the ability of SSRIs to increase neurogenesis across the postpartum but it may be related to the hormonal milieu and changes to serotonin signalling during the postpartum period.…”

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confidence: 99%

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Beyond sex differences: short and long-term implications of motherhood on women’s health

Galea

Qiu

Duarte‐Guterman

2018

Current Opinion in Physiology

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“…Collectively, these data suggest exercise enhanced the effect of fluoxetine on neurogenesis during the postpartum period and might be an effective adjunct treatment to pharmacotherapies. High running alone did not affect acute swim stress‐induced CORT concentrations or CORT concentrations following 2 hr recovery (Gobinath et al, ). Thus, mechanisms independent of the HPA axis might modulate the combined effect of exercise and fluoxetine on hippocampal neurogenesis.…”

Section: Hippocampal Neurogenesis Across Pregnancy the Postpartum Pementioning

confidence: 99%

Maternal experience and adult neurogenesis in mammals: Implications for maternal care, cognition, and mental health

Medina

Workman

2018

J of Neuroscience Research

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The transition to motherhood encompasses physiological and behavioral adaptations essential for the initiation and maintenance of offspring care and feeding and includes widespread changes throughout the brain. The growth of new neurons occurs across the lifespan in distinct regions of mammalian brains and changes dynamically across reproductive events in female mammals. The subventricular zone (SVZ) and dentate gyrus (DG) of the hippocampus undergo high rates of neurogenesis in adulthood and are sensitive to hormonal fluctuations. Pregnancy and the postpartum period are associated with increased cell proliferation in the SVZ and interneuron survival in the olfactory bulb. In mice, peripartum prolactin signaling mediates SVZ neurogenesis and is important for enhanced olfactory recognition of offspring and maternal care. In contrast, cell proliferation and immature neuron survival decrease in the DG during the postpartum period. High baseline glucocorticoid concentrations suppress hippocampal neurogenesis, potentially representing an energetic trade-off accompanying a reduced need for spatial navigation early postpartum. In women, hippocampal volume decline during pregnancy and partial recovery during the postpartum period could contribute to the risk of psychiatric illness. New evidence indicates that the dorsal raphe nucleus (DR) is an additional site for adult neurogenesis sensitive to reproductive experience and offspring contact. In this review, we discuss the initial and lasting impact of maternal experience on adult neurogenesis. Because neurogenesis has been implicated in a variety of psychiatric and neurodegenerative illnesses, understanding how reproductive experience alters new neuron production in maternal mammals has far-reaching implications for women's health and wellness across the lifespan.

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Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression

Cited by 48 publications

References 65 publications

Serotonin and motherhood: From molecules to mood

Serotonin and motherhood: From molecules to mood

Beyond sex differences: short and long-term implications of motherhood on women’s health

Maternal experience and adult neurogenesis in mammals: Implications for maternal care, cognition, and mental health

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