Voluntary Running Exercise Alters Microbiota Composition and Increases n-Butyrate Concentration in the Rat Cecum

Matsumoto, Megumi; Inoüe, Ryo; Tsukahara, Takamitsu; Ushida, Kazunari; Chiji, Hideyuki; Matsubara, Noritaka; Hara, Hiroshi

doi:10.1271/bbb.70474

Cited by 284 publications

(249 citation statements)

References 19 publications

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“…12 Notable differences in microbiota composition have also been shown between exercised and sedentary rats. 14 Nevertheless, the associations between specific gut bacteria and human host metabolism and immunity in relation to obesity remain largely uncharacterized. The objective of this study was to evaluate the effects of a multidisciplinary obesity treatment programme (including energy-restricted diet and increased physical activity) on fecal microbial composition and immunoglobulin-coating bacteria in overweight or obese adolescents and assess their relationship to biochemical parameters and weight loss.…”

Section: Introductionmentioning

confidence: 99%

Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents

et al. 2008

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Objective: To evaluate the effects of a multidisciplinary obesity treatment programme on fecal microbiota composition and immunoglobulin-coating bacteria in overweight and obese adolescents and their relationship to weight loss. Design: Longitudinal intervention study based on both a calorie-restricted diet (calorie reduction ¼ 10-40%) and increased physical activity (calorie expenditure ¼ 15-23 kcal/kg body weight per week) for 10 weeks. Participants: Thirty-nine overweight and obese adolescents (BMI mean 33.1 range 23.7-50.4; age mean 14.8 range, 13.0-16.0). Measurements: BMI, BMI z-scores and plasma biochemical parameters were measured before and after the intervention. Fecal microbiota was analyzed by fluorescent in situ hybridization. Immunoglobulin-coating bacteria were detected using fluorescentlabelled F(ab 0 )2 antihuman IgA, IgG and IgM. Results: Reductions in Clostridium histolyticum and E. rectale-C. coccoides proportions significantly correlated with weight and BMI z-score reductions in the whole adolescent population. Proportions of C. histolyticum, C. lituseburense and E. rectale-C. coccoides dropped significantly whereas those of the Bacteroides-Prevotella group increased after the intervention in those adolescents who lost more than 4 kg. Total fecal energy was almost significantly reduced in the same group of adolescents but not in the group that lost less than 2.5 kg. IgA-coating bacterial proportions also decreased significantly in participants who lost more than 6 kg after the intervention, paralleled to reductions in C. histolyticum and E. rectale-C. coccoides populations. E. rectale-C. coccoides proportions also correlated with weight loss and BMI z-score reduction in participants whose weight loss exceeded 4 kg. Conclusions: Specific gut bacteria and an associated IgA response were related to body weight changes in adolescents under lifestyle intervention. These results suggest interactions between diet, gut microbiota and host metabolism and immunity in obesity.

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Section: Introductionmentioning

confidence: 99%

Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents

et al. 2008

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“…Also, SCFA levels of butyrate were found significantly increased in male Wistar rats subjected to a free-wheel running protocol with respect to sedentary controls [75]. As said, SCFAs are one of the major end products of microbial fermentation and contribute to intestinal energy homeostasis by modulating immune system and reducing inflammation and oxidative stress.…”

Section: Animal Studiesmentioning

confidence: 84%

“…Matsumoto et al hypothesized that cecal butyrate concentrations were inversely related to colon disease risks due to exercise [75]. Other animal studies supported the exercise-induced increase in butyrate-producing bacteria [76], however results might vary according to the protocol employed (voluntary-versus controlled exercise) [77].…”

Section: Animal Studiesmentioning

confidence: 99%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella

Luzi

Terruzzi³

2018

Digestive and Liver Disease

124

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Please cite this article as: Codella Roberto, Luzi Livio, Terruzzi Ileana.Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases.Digestive and Liver Disease https://doi.org/10.1016/j.dld. 2017.11.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractLimited animal and human research findings implied that exercise might have a

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“…Matsumoto et al [45] were the first to show that voluntary exercise in animals is able to change SCFA production (mainly n-butyrate) in the cecum. In addition, this study reported alteration in the cecal microbiota profile after exercise with greater predominance of butyrate-producing bacteria species [45]. This shift in butyrate production and bacteria composition in the exercised group was also shown by Evans et al [43].…”

Section: Short-chain Fatty Acidsmentioning

confidence: 99%

“…Matsumoto et al [45] were among the first to report that physical exercise modifies intestinal microbiota composition. More recently, it has been shown that the effects of exercise on intestinal microbiota are partly independent from dietary changes [76].…”

Section: Physical Exercise and Colonic Luminal Content Characteristicsmentioning

confidence: 99%

Colon epithelial cells luminal environment and physiopathological consequences: impact of nutrition and exercise

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et al. 2018

Nutrire

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The colonic epithelial cells represent a border between the colon luminal content, containing notably bacteria and a complex mixture of compounds, and the "milieu interieur" as defined by the French physiologist Claude Bernard. The physical-chemical composition of the luminal content, including luminal pH and bacterial metabolite, that obviously is not constant, is modified for instance according to the diet. Data obtained recently indicate that physical exercise may also modify the colonic luminal content. Evidence has indicated that modification of the luminal content characteristics has, indeed, consequences for the colonic epithelial cells, notably in terms of energy metabolism and DNA integrity. Although such alterations impact presumably the homeostatic process of the colonic epithelium renewal and the epithelial barrier function, their contribution to pathological processes like mucosal inflammation, pre-neoplasia, and neoplasia remains partly elusive. Open questions remain regarding the individual and collective roles of luminal changes, particularly in a long-term perspective. These questions are related particularly to the capacity of the bacterial metabolites to cross the mucus layer before entering the colonocytes, to the concentrations of metabolites in proximity of the colonic crypt stem cells, and to the capacity of colonocytes to detoxicate deleterious compounds, to take up and utilize beneficial compounds.

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Voluntary Running Exercise Alters Microbiota Composition and Increases n-Butyrate Concentration in the Rat Cecum

Cited by 284 publications

References 19 publications

Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents

Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Colon epithelial cells luminal environment and physiopathological consequences: impact of nutrition and exercise

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