Voluntary running counteracts right ventricular adverse remodeling and myocyte contraction impairment in pulmonary arterial hypertension model

Soares, Leôncio Lopes; Drummond, Filipe Rios; Rezende, Leonardo Mateus Teixeira de; Costa, Alexandre Jaime Lopes Dantas; Leal, Tiago Ferreira; Fidélis, Meilene Ribeiro; Machado‐Neves, Mariana; Prímola-Gomes, Thales Nicolau; Carneiro‐Júnior, Miguel Araujo; Reis, Emily Correna Carlo; Natali, Antônio José

doi:10.1016/j.lfs.2019.116974

Cited by 13 publications

(18 citation statements)

References 52 publications

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“…Consistently, in MCT‐induced mild PAH rats, exercise training was found to attenuate RV fibrosis and improve RV systolic pressure, thus improving RV function 18 , 19 . Another study also showed that voluntary running could delay PVR increases, RV adverse remodelling and subsequently the heart failure onset in PAH rats induced by MCT 20 …”

Section: Effects Of Exercise Rehabilitation Training On Vascular and Right Ventricular Remodellingmentioning

confidence: 73%

“…Exercise tolerance and quality of life 6MWD" [6][7][8]12,14 Quality of life score" [6][7][8] Heart rate at rest# 7 pVO2" [6][7][8] Oxygen saturation" 7 Maximal workload " 7 1-, 2-and 3-year survival rate" 7 Vascular and right ventricular remodelling Tissue level: Intramyocardial capillaries" 17 RV extracellular matrix# [18][19][20] RV systolic pressure" 18,19 Pulmonary artery thickness# 22,26 Pulmonary artery resistance# 20 Cardiac hypertrophy 18,[23][24][25] Molecule level: P-GSK-3/GSK-3# 22 Pulmonary eNOS" 18 SERCA2a# 19 Neurohumoral activation# 19…”

Section: Effects Of Exercise Rehabilitation Training On Exercise Tolementioning

confidence: 99%

“…18,19 Another study also showed that voluntary running could delay PVR increases, RV adverse remodelling and subsequently the heart failure onset in PAH rats induced by MCT. 20 The processes of vascular and RV remodelling involve a multitude of cellular and molecular elements. Glycogen synthesis kinase (GSK-3) is a protein that is inactivated by phosphorylation, and it has been found to be involved in cardiac hypertrophy and angiogenesis.…”

Section: Effects Of Exercise Rehabilitation Training On Vascular and mentioning

confidence: 99%

“… 18 , 19 Another study also showed that voluntary running could delay PVR increases, RV adverse remodelling and subsequently the heart failure onset in PAH rats induced by MCT. 20 …”

Section: Effects Of Exercise Rehabilitation Training On Vascular and mentioning

confidence: 99%

“…Vascular and right ventricular remodelling Tissue level: Intramyocardial capillaries↑ 17 RV extracellular matrix↓ 18–20 RV systolic pressure↑ 18 , 19 Pulmonary artery thickness↓ 22 , 26 Pulmonary artery resistance↓ 20 Cardiac hypertrophy 18 , 23–25 …”

Section: Introductionmentioning

confidence: 99%

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Effects of exercise rehabilitation training on patients with pulmonary hypertension

Zhang

2020

Pulm. circ.

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Pulmonary hypertension (PH) comprises a group of pathophysiological syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, which lead to right ventricular overload, and even right heart failure. PH has a poor prognosis and severely leads to a decline in quality of life. Historically, patients with PH were advised to limit their physical activity. However, an increasing number of studies have reported the safety and efficacy of exercise rehabilitation training in PH. This review briefly examined and summarized the effects of exercise rehabilitation training on PH patients reported in the recent literature. The findings of the reviewed studies indicate that exercise rehabilitation training in PH patients has beneficial effects in terms of exercise capacity and quality of life, vascular and right ventricle remodelling, inflammatory response, muscular function and oxidative stress. However, the underlying mechanisms and appropriate exercise strategies (e.g. the duration and intensity of exercise) still need to be explored. In conclusion, exercise rehabilitation training of the appropriate intensity and frequency can improve the prognosis and quality of life of PH patients. The training should be monitored by professional staff and be provided as an adjunct to pharmacological treatment. Larger clinical trials are required to confirm the safety and efficacy of exercise rehabilitation training in PH.

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Section: Effects Of Exercise Rehabilitation Training On Vascular and Right Ventricular Remodellingmentioning

confidence: 73%

Section: Effects Of Exercise Rehabilitation Training On Exercise Tolementioning

confidence: 99%

Section: Effects Of Exercise Rehabilitation Training On Vascular and mentioning

confidence: 99%

“… 18 , 19 Another study also showed that voluntary running could delay PVR increases, RV adverse remodelling and subsequently the heart failure onset in PAH rats induced by MCT. 20 …”

Section: Effects Of Exercise Rehabilitation Training On Vascular and mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of exercise rehabilitation training on patients with pulmonary hypertension

Zhang

2020

Pulm. circ.

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Resistance exercise training benefits pulmonary, cardiac, and muscular structure and function in rats with stable pulmonary artery hypertension

Soares,

Leite,

Ervilha

et al. 2023

Life Sciences

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Effect of Induced Pulmonary Arterial Hypertension on Testicular Parameters of Wistar Rats Subjected to Resistance Exercise Training

Ervilha

Soares

Bento

et al. 2023

Microscopy and Microanalysis

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Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. However, it remains unclear whether monocrotaline-induced PAH exerts detrimental effects on animal testes. Thus, we analyzed the impact of PAH on testicular morphology and function. Additionally, we investigated the effect of resistance exercise training (RT) on testicular parameters in PAH rats. Eight healthy Wistar rats and eight PAH rats were subjected to RT training for 30 days; the other PAH and healthy rats (n = 8/group) did not exercise. PAH rats had lower reproductive organ weight, serum testosterone levels, testicular glucose, and nitric oxide (NO) levels, Leydig cell parameters, tubular morphometry, germ cell counts, and daily sperm production than healthy animals did. The practice of RT attenuated the negative impact of PAH on the relative weights of the testes and epididymides, Leydig cell number, nuclear volume, testicular NO levels, and seminiferous epithelium architecture. Moreover, RT positively influenced testosterone levels in PAH animals. We conclude that PAH exerts deleterious effects on testicular histology and function. However, RT can be beneficial to the PAH-affected testicular parameters.

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Voluntary running counteracts right ventricular adverse remodeling and myocyte contraction impairment in pulmonary arterial hypertension model

Cited by 13 publications

References 52 publications

Effects of exercise rehabilitation training on patients with pulmonary hypertension

Effects of exercise rehabilitation training on patients with pulmonary hypertension

Resistance exercise training benefits pulmonary, cardiac, and muscular structure and function in rats with stable pulmonary artery hypertension

Effect of Induced Pulmonary Arterial Hypertension on Testicular Parameters of Wistar Rats Subjected to Resistance Exercise Training

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