Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia

doi:10.31083/j.jin.2019.01.118

Cited by 4 publications

(2 citation statements)

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“…Different modalities of swimming exercise are known to elicit a preconditioning effect [ 73 , 74 ], able to attenuate or reverse cerebral injury in the early stage after ischemia [ 75 ], and improve cognition [ 76 ]. Furthermore, NO production from the three NOS isoforms [ 77 ] and increased hydroxyl radical rate [ 78 ] triggered by aerobic exercise participate in the formation of associative and spatial memory [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat

Aguilar-Peralta

Gonzalez-Vazquez

Tomás-Sanchez

et al. 2022

Behavioural Neurology

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Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined effect of subacute prophylactic zinc administration and swimming exercise in a transient cerebral ischemia model. The prophylactic zinc administration (2.5 mg/kg of body weight) was provided every 24 h for four days before a 30 min common carotid artery occlusion (CCAO), and 24 h after reperfusion, the rats were subjected to swimming exercise in the Morris Water Maze (MWM). Learning was evaluated daily for five days, and memory on day 12 postreperfusion; anxiety or depression-like behavior was measured by the elevated plus maze and the motor activity by open-field test. Nitrites, lipid peroxidation, and the activity of superoxide dismutase (SOD) and catalase (CAT) were assessed in the temporoparietal cortex and hippocampus. The three nitric oxide (NO) synthase isoforms, chemokines, and their receptor levels were measured by ELISA. Nissl staining evaluated hippocampus cytoarchitecture and Iba-1 immunohistochemistry activated the microglia. Swimming exercise alone could not prevent ischemic damage but, combined with prophylactic zinc administration, reversed the cognitive deficit, decreased NOS and chemokine levels, prevented tissue damage, and increased Iba-1 (+) cell number. These results suggest that the subacute prophylactic zinc administration combined with swimming exercise, but not the individual treatment, prevents the ischemic damage on day 12 postreperfusion in the transient ischemia model.

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Section: Discussionmentioning

confidence: 99%

Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat

Aguilar-Peralta

Gonzalez-Vazquez

Tomás-Sanchez

et al. 2022

Behavioural Neurology

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“…Thus, it effectively reduced the expression of caspase-3 and inhibited neuronal apoptosis ( Choi et al, 2013 ). Zhang et al (2019) . showed that voluntary wheel running inhibits cellular apoptosis by downregulating the Bax/Bcl-2 ratio and caspase-3 protein expression.…”

Section: Mechanism Of Exercise Preconditioning Induced Cerebral Ische...mentioning

confidence: 99%

Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke

Zhu¹,

Sun²,

Hu³

et al. 2022

Front. Pharmacol.

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Exercise preconditioning has attracted extensive attention to induce endogenous neuroprotection and has become the hotspot in neurotherapy. The training exercise is given multiple times before cerebral ischemia, effectively inducing ischemic tolerance and alleviating secondary brain damage post-stroke. Compared with other preconditioning methods, the main advantages of exercise include easy clinical operation and being readily accepted by patients. However, the specific mechanism behind exercise preconditioning to ameliorate brain injury is complex. It involves multi-pathway and multi-target regulation, including regulation of inflammatory response, oxidative stress, apoptosis inhibition, and neurogenesis promotion. The current review summarizes the recent studies on the mechanism of neuroprotection induced by exercise, providing the theoretical basis of applying exercise therapy to prevent and treat ischemic stroke. In addition, we highlight the various limitations and future challenges of translational medicine from fundamental study to clinical application.

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The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke

Kheravi

Nayebifar

Aletaha

et al. 2021

BioMed Research International

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Despite the beneficial effects of exercise and physical activity, there is little knowledge about the effects of different types of physical activity on neural function. The present study assessed the effects of two types of selected aerobic exercises prior to stroke induction and characterized the expression of TrkB, TNF-α, and MMP2 genes in vivo. Forty male adult Wistar rats were exposed to aerobic exercises following randomization into four groups, including swimming + MCAO (Middle Cerebral Artery Occlusion) ( n = 10 ), treadmill training + MCAO ( n = 10 ), MCAO ( n = 10 ), and control ( n = 10 ). The swimming + MCAO group included swimming for 30 minutes each day, while the treadmill training + MCAO group program involved running for 30 minutes each day at an intensity of 15 m/min, for three weeks, five days a week. Neurological deficit was assessed using modified criteria at 24 h after the onset of cerebral ischemia. In the control group, the animals worked freely for three weeks without undergoing ischemia. The MCAO group also operated freely for three weeks after they underwent a stroke. Both training groups underwent ischemia after three weeks of training. TrkB, TNF-α, and MMP2 gene expressions were increased in the MCAO+ swimming training and in the MCAO + running training group compared to the control and MCAO groups, respectively. Preconditioning aerobic exercises significantly increased brain trophic support and reduced brain damage conditions in exercise groups, which support the importance of aerobic exercise in the prevention and treatment of stroke.

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Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia

Cited by 4 publications

References 45 publications

Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat

Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat

Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke

The Effect of Two Types of Exercise Preconditioning on the Expression of TrkB, TNF-α, and MMP2 Genes in Rats with Stroke

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