Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity

Kahler‐Quesada, Arianna; Grant, Kathleen A.; Walter, Nicole A.R.; Newman, Natali; Allen, Matthew R.; Burr, David B.; Branscum, Adam J.; Maddalozzo, Gianni F.; Turner, Russell T.; Iwaniec, Urszula T.

doi:10.1111/acer.14202

Cited by 22 publications

(19 citation statements)

References 62 publications

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“…For skeletal system, low dosage of ethanol might be beneficial but high levels of ethanol consumption resulted in turnover imbalance where bone resorption exceeded formation . A very recent study indicated that a high dose of ethanol mainly decreased the function of osteoblast, without a significant impact on osteoclast activity . Our pilot study, as well as some others’, revealed that both trabecular and cortical bone were sensitive to long‐term and high‐dose ethanol .…”

Section: Discussionsupporting

confidence: 60%

“…2,[58][59][60] A very recent study indicated that a high dose of ethanol mainly decreased the function of osteoblast, without a significant impact on osteoclast activity. 61 Our pilot study, as well as some others', revealed that both trabecular and cortical bone were sensitive to long-term and high-dose ethanol. 12,62 Intriguingly, it was demonstrated that in the rat model, cortical bone was more vulnerable to high dose of ethanol than trabecular bone.…”

Section: Discussionmentioning

confidence: 48%

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miR‐136‐3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol‐induced osteopenia

Chen

Zhu

et al. 2020

The FASEB Journal

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Alcohol consumption is regarded as one of the leading risk factors for secondary osteopenia. Coupled angiogenesis and osteogenesis via distinct type‐H vessels orchestrates subtle biological processes of bone homeostasis. The dysfunction of angiogenesis and osteogenesis contributes to decreased bone mass during the development of osteopenia. Herein, we identified microRNA‐136‐3p was remarkedly downregulated in the mouse model of alcohol‐induced osteopenia. Following the alcohol administration, downregulated microRNA‐136‐3p significantly suppressed vascularization and osteogenic differentiation in human umbilical vein endothelial cells (HUVECs) and bone mesenchymal stem cells (BMSCs), respectively. Furthermore, microRNA‐136‐3p could target phosphatase and tensin homolog deleted on chromosome ten (PTEN) in both HUVECs and BMSCs, thus substantially modulating the capacity of vessel formation and osteogenic differentiation. In the mouse model, microRNA‐136‐3p Agomir ameliorated alcohol‐induced osteopenia, with the concomitant restoration of bone mass and type‐H vessel formation. For the first time, this study demonstrated the pivotal role of microRNA‐136‐3p/PTEN axis in regulations of vascularization and bone formation, which might become the potential therapeutic target of alcohol‐induced bone loss.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 48%

miR‐136‐3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol‐induced osteopenia

Chen

Zhu

et al. 2020

The FASEB Journal

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“…This variation might be attributed to the different biological responses of relevant bone cells trying to repair necrotic tissue 54 , re ecting distinct effects of these two etiologies. It has been proposed that glucocorticoid and alcohol reduce femoral artery perfusion through mechanisms such as vascular endothelial injury and microvascular thrombosis 55,56 . They can also induce the formation of intramedullary fat, which increases the pressure in the bones, leading to venous congestion and blocked arteries 19,57,58 .…”

Section: Discussionmentioning

confidence: 99%

Differences in the Microarchitectural and Histomorphologic Characteristics Between Glucocorticoid-induced Osteonecrosis of Femoral Head and Alcohol-induced Osteonecrosis of Femoral Head

Chen

Liu

et al. 2021

Preprint

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AimsTo analyze microarchitecture and histomorphology characteristics of different regions in femoral heads from patients with glucocorticoid-induced osteonecrosis of femoral head (GIONFH) and alcohol-induced osteonecrosis of femoral head (AIONFH). MethodsPatients diagnosed with GIONFH and AIONFH were recruited. Femoral heads were obtained after total hip replacement. Micro-CT was applied to evaluate the microstructure of 9 regions of interest (ROIs) in the femoral head. Along the supero-inferior orientation, the femoral head was divided into necrotic region, reactive interface, and normal region; along the medio-lateral orientation, the femoral head was divided into medial region, central region and lateral region. Decalcified and undecalcified bone histology were then performed to assess histopathological alterations and bone remodeling levels. Results42 GIONFH patients (50 hips) and 43 AIONFH patients (50 hips) anticipated in the study. In the necrotic region, most of the microarchitectural parameters did not differ significantly between GIONFH and AIONFH, whereas both the reactive interface and normal region illustrated significant differences in the microstructure and histomorphometry. The reactive interface and normal region exhibited a less sclerotic microarchitecture, but a higher bone remodeling level in GIONFH as compared with AIONFH. Despite similar necrotic pathological manifestations, subchondral trabecular microfracture in the necrotic region was more severe and vasculature of the reactive interface was more abundant in GIONFH. ConclusionsAlthough these two subtypes of ONFH shared similar microarchitecture and pathological features in the necrotic region, GIONFH exhibited a less sclerotic microarchitecture and a more active bone metabolic status in both the reactive interface and normal region.

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“…The findings from a study on voluntary chronic heavy alcohol consumption in male rhesus macaques revealed that voluntary chronic heavy alcohol consumption reduces cancellous bone formation in lumbar vertebra by decreasing osteoblast-lined bone perimeter, a response associated with an increase in bone marrow adiposity (90).…”

Section: Mood Disorders (Bipolar Disorder Cyclothymic Disorder and Dmentioning

confidence: 99%

Chronic Alcohol Use and Accompanying Noncommunicable Diseases

Ayenigbara

2020

Croat. nurs. j. (Online)

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Introduction. Heavy and chronic alcohol use connotes frequent, continuous and persistent consumption of alcoholic drinks over an extended period of time. Importantly, heavy consumption of alcohol causes many health problems to the drinker and the society at large, as over 5.1% of the global burden of morbidity and injuries are attributable to alcohol usage alone. Aim. The purpose of this study is to identify some of the noncommunicable diseases that are associated with chronic alcohol consumption through a systematic and narrative review, with detailed descriptions of the occurrences. Methods. A systematic and narrative review of literature that evaluates noncommunicable diseases associated with chronic alcohol consumption was carried out using Google, Medline and databases of major international health organizations. Keywords used as search terms were alcoholism, chronic alcohol use and heavy alcohol use; these terms were matched with occurrences and risk of noncommunicable diseases. Studies included in this review are clinical trials, meta-analyses, randomized controlled trials, and systematic and review articles. Results. The findings revealed that chronic alcohol use is either a single or joint risk factor for Alzheimer’s disease and dementia, arthritis, brain malfunction, cancer (most commonly of the oropharynx, larynx, oesophagus, liver, colon, rectum or breast), chronic obstructive pulmonary disease (COPD), diabetes, epilepsy, heart diseases and cardiovascular diseases, immune system dysfunction, malnourishment and vitamin deficiencies, mood disorders, bipolar disorder and depression, osteoporosis and bone malformation, pancreatitis, and ulcers and gastrointestinal problems. Conclusion. These findings are background information as they revealed some of the noncommunicable diseases associated with chronic alcohol use. Hence, more and precise long-term cohort studies are necessary for a better understanding of the occurrences and epidemiology of noncommunicable diseases as a result of chronic alcohol use.

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Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity

Cited by 22 publications

References 62 publications

miR‐136‐3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol‐induced osteopenia

miR‐136‐3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol‐induced osteopenia

Differences in the Microarchitectural and Histomorphologic Characteristics Between Glucocorticoid-induced Osteonecrosis of Femoral Head and Alcohol-induced Osteonecrosis of Femoral Head

Chronic Alcohol Use and Accompanying Noncommunicable Diseases

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