Volumetry improves the assessment of the vestibular aqueduct size in inner ear malformation

Weiss, Nora M.; Breitsprecher, Tabita M.; Pscheidl, Alexander; Bächinger, David; Volkenstein, Stefan; Dazert, Stefan; Mlynski, Robert; Langner, Sönke; Roland, Peter S.; Dhanasingh, Anandhan

doi:10.1007/s00405-022-07681-4

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…For linear measurements of the VA, the Cincinnati protocol was followed ( 90 ). On the other hand, following the recommendations of Weiss et al ( 91 ), the volume of the VA was measured, establishing its limits at the intersection of this structure with the vestibule and in the plane perpendicular to the opercular rim.…”

Section: Methodsmentioning

confidence: 99%

The child who lived: Down syndrome among Neanderthals?

Conde-Valverde,

Quirós-Sánchez,

Diez-Valero

et al. 2024

Sci. Adv.

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Caregiving for disabled individuals among Neanderthals has been known for a long time, and there is a debate about the implications of this behavior. Some authors believe that caregiving took place between individuals able to reciprocate the favor, while others argue that caregiving was produced by a feeling of compassion related to other highly adaptive prosocial behaviors. The study of children with severe pathologies is particularly interesting, as children have a very limited possibility to reciprocate the assistance. We present the case of a Neanderthal child who suffered from a congenital pathology of the inner ear, probably debilitating, and associated with Down syndrome. This child would have required care for at least 6 years, likely necessitating other group members to assist the mother in childcare

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Section: Methodsmentioning

confidence: 99%

The child who lived: Down syndrome among Neanderthals?

Conde-Valverde,

Quirós-Sánchez,

Diez-Valero

et al. 2024

Sci. Adv.

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“…Recent research has found that LVAS can be better diagnosed by measuring the 3D volume of VA (Boston et al, 2007;Weiss et al, 2022). In this study, LVAS was diagnosed by measuring the width of the VA operculum and midpoint.…”

Section: The Rationality Of the Modelmentioning

confidence: 95%

Fluid-solid coupling model and biological features of large vestibular aqueduct syndrome

Chen

Luo

Zhou

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: Computed tomography (CT) images of the temporal bone of large vestibular aqueduct syndrome (LVAS) patients were used to establish 3D numerical models based on the structure of the inner ear, which are, in turn, used to construct inner ear fluid-solid coupling models. The physiological features and pathophysiology of LVAS were analyzed from a biomechanical perspective using finite element analysis.Methods: CT images of the temporal bone were collected from five children attending the Second Hospital of Dalian Medical University in 2022. The CT images were used to build 3D models of the inner ear containing the vestibular aqueduct (VA) by Mimics and Geomagic software, and round window membrane models and fluid-solid coupling models were built by ANSYS software to perform fluid-solid coupling analysis.Results: By applying different pressure loads, the deformation of the round window membranes occurred, and their trend was basically the same as that of the load. The deformation and stress of the round window membranes increased with the increase in load. Under the same load, the deformation and stress of the round window membranes increased with the expansion of the midpoint width of the VA.Conclusion: CT images of the temporal bone used clinically could establish a complete 3D numerical model of the inner ear containing VA. Fluctuations in cerebrospinal fluid pressure could affect inner ear pressure, and VA had a limiting effect on the pressure from cerebrospinal fluid. The larger the VA, the smaller the limiting effect on the pressure.

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Internal auditory canal volume in normal and malformed inner ears

Bächinger

Breitsprecher

Pscheidl

et al. 2022

Eur Arch Otorhinolaryngol

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Purpose A narrow bony internal auditory canal (IAC) may be associated with a hypoplastic cochlear nerve and poorer hearing performances after cochlear implantation. However, definitions for a narrow IAC vary widely and commonly, qualitative grading or two-dimensional measures are used to characterize a narrow IAC. We aimed to refine the definition of a narrow IAC by determining IAC volume in both control patients and patients with inner ear malformations (IEMs). Methods In this multicentric study, we included high-resolution CT (HRCT) scans of 128 temporal bones (85 with IEMs: cochlear aplasia, n = 11; common cavity, n = 2; cochlear hypoplasia type, n = 19; incomplete partition type I/III, n = 8/8; Mondini malformation, n = 16; enlarged vestibular aqueduct syndrome, n = 19; 45 controls). The IAC diameter was measured in the axial plane and the IAC volume was measured by semi-automatic segmentation and three-dimensional reconstruction. Results In controls, the mean IAC diameter was 5.5 mm (SD 1.1 mm) and the mean IAC volume was 175.3 mm3 (SD 52.6 mm3). Statistically significant differences in IAC volumes were found in cochlear aplasia (68.3 mm3, p < 0.0001), IPI (107.4 mm3, p = 0.04), and IPIII (277.5 mm3, p = 0.0004 mm3). Inter-rater reliability was higher in IAC volume than in IAC diameter (intraclass correlation coefficient 0.92 vs. 0.77). Conclusions Volumetric measurement of IAC in cases of IEMs reduces measurement variability and may add to classifying IEMs. Since a hypoplastic IAC can be associated with a hypoplastic cochlear nerve and sensorineural hearing loss, radiologic assessment of the IAC is crucial in patients with severe sensorineural hearing loss undergoing cochlear implantation.

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Volumetry improves the assessment of the vestibular aqueduct size in inner ear malformation

Cited by 5 publications

References 46 publications

The child who lived: Down syndrome among Neanderthals?

The child who lived: Down syndrome among Neanderthals?

Fluid-solid coupling model and biological features of large vestibular aqueduct syndrome

Internal auditory canal volume in normal and malformed inner ears

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