Volumetric variation in subregions of the cerebellum correlates with working memory performance

Ding, Hui; Qin, Wen; Jiang, Tianzi; Zhang, Yunting; Yu, Chunshui

doi:10.1016/j.neulet.2011.12.016

Cited by 41 publications

(27 citation statements)

References 52 publications

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“…Additionally, previous studies have shown that cerebellar (Ding et al, 2012), striatum, lateral prefrontal and frontoparietal grey matter volume alterations are associated with WM capacity (Ruge and Wolfensteller, 2015), and that larger volume in the lateral prefrontal cortex is particularly susceptible to variations in WM capacity (Reid et al, 2015). Furthermore, training using a WM task has been associated with reductions in frontoparietal network volume (Takeuchi et al, 2011), although there is some indication that basal ganglia networks are more susceptible to WM training (Klingberg, 2014).…”

Section: Discussionmentioning

confidence: 99%

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

Brooks

Burch

Maiorana

et al. 2016

NeuroImage: Clinical

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BackgroundProtracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known.Methods66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18–50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa. 17 MA patients received 4 weeks of treatment as usual (TAU), and 24 MA patients completed TAU plus daily 30-minute cognitive training (CT) using an N-back working memory task. Magnetic resonance imaging (MRI) at baseline and 4-week follow-up was acquired and voxel-based morphometry (VBM) was used for analysis.ResultsTAU was associated with larger bilateral striatum (caudate/putamen) volume, whereas CT was associated with more widespread increases of the bilateral basal ganglia (incorporating the amygdala and hippocampus) and reduced bilateral cerebellum volume coinciding with improvements in impulsivity scores.ConclusionsWhile psychological intervention is associated with larger volume in mesolimbic reward regions, the utilisation of additional working memory training as an adjunct to treatment may further normalize frontostriatal structure and function.

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Section: Discussionmentioning

confidence: 99%

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

Brooks

Burch

Maiorana

et al. 2016

NeuroImage: Clinical

View full text Add to dashboard Cite

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“…WM was assessed with a letter 2-back task as described previously (Ding et al , 2012). Briefly, each participant viewed a series of letters that were presented sequentially and was asked to judge whether the letter on the screen was identical to the one presented two trials back.…”

Section: Methodsmentioning

confidence: 99%

The Impact of MIR137 on Dorsolateral Prefrontal–Hippocampal Functional Connectivity in Healthy Subjects

Liu

Zhang

Hou

et al. 2014

Neuropsychopharmacol

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A recent mega-analysis combining genome-wide association study data revealed that a variant of microRNA 137 (MIR137) exhibits the most significant association with schizophrenia. Other biological evidence also consistently suggests that MIR137 may have a pivotal role in the pathogenesis of schizophrenia. However, the underlying neural mechanism remains unclear. As the disrupted dorsolateral prefrontal cortex (DLPFC) coupling with the hippocampal formation (HF) has been widely observed in schizophrenia patients, DLPFC-HF dysconnectivity can therefore be thought of as a pivotal intermediate phenotype that links genetic variants of psychiatric risk genes to schizophrenia. This study used resting-state functional magnetic resonance imaging to test whether the MIR137 variant (rs1625579) impacts DLPFC-HF functional connectivity and cognitive performance in 290 young, healthy Han Chinese individuals. To identify functional connectivity between DLPFC and HF, a seed-based functional connectivity analysis was used. The association between DLPFC-HF connectivity and working memory performance was further examined in individuals with different MIR137 genotypes. The individuals who are homozygous for the MIR137 risk allele (TT), which confers a high risk for schizophrenia, exhibited significantly different DLPFC-HF functional connectivity compared with TG individuals. Moreover, the DLPFC-HF connectivity could predict the working memory performance in MIR137 TG individuals, but not in TT individuals. The current findings obtained in a large sample of healthy participants identified potential neural mechanisms linking MIR137 with the risk of developing schizophrenia via the intermediate phenotype of DLPFC-HF connectivity.

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“…Finally, the results were displayed using FSLviewer (http://fsl.fmrib.ox.ac.uk/fsl/fslview/). Generally, AlphaSim is widely used in previous literatures about VBM data analysis (DeYoung et al, 2010;Schwartz et al, 2010;Ding et al, 2012;Zou et al, 2012;Farb et al, 2013;Kong et al, 2013;Yang et al, 2013). Although the results corrected by Monte Carlo simulation might have some limitations reported in the study of Silver et al (2011), it can provide the appropriate cluster-level threshold to achieve the desired false-positive rate.…”

Section: Mri Data Analysismentioning

confidence: 99%

Brain structure links trait creativity to openness to experience

Li¹,

Li²,

Huang³

et al. 2014

Social Cognitive and Affective Neuroscience

122

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Creativity is crucial to the progression of human civilization and has led to important scientific discoveries. Especially, individuals are more likely to have scientific discoveries if they possess certain personality traits of creativity (trait creativity), including imagination, curiosity, challenge and risk-taking. This study used voxel-based morphometry to identify the brain regions underlying individual differences in trait creativity, as measured by the Williams creativity aptitude test, in a large sample (n ¼ 246). We found that creative individuals had higher gray matter volume in the right posterior middle temporal gyrus (pMTG), which might be related to semantic processing during novelty seeking (e.g. novel association, conceptual integration and metaphor understanding). More importantly, although basic personality factors such as openness to experience, extroversion, conscientiousness and agreeableness (as measured by the NEO Personality Inventory) all contributed to trait creativity, only openness to experience mediated the association between the right pMTG volume and trait creativity. Taken together, our results suggest that the basic personality trait of openness might play an important role in shaping an individuals trait creativity.

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Volumetric variation in subregions of the cerebellum correlates with working memory performance

Cited by 41 publications

References 52 publications

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

The Impact of MIR137 on Dorsolateral Prefrontal–Hippocampal Functional Connectivity in Healthy Subjects

Brain structure links trait creativity to openness to experience

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