Volumetric reduction of the corpus callosum in Alzheimer's disease in vivo as assessed with voxel-based morphometry

Chaim, Tiffany M.; Duran, Fábio L.S.; Uchida, Ricardo Riyoiti; Périco, Cintia Azevedo Marques; Castro, Cláudio Campi de; Busatto, Geraldo F.

doi:10.1016/j.pscychresns.2006.04.003

Cited by 74 publications

(76 citation statements)

References 46 publications

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“…The involvement of this tract as well as the CC, fornix, perforant path, and temporal WM is consistent with previous findings from DTI studies that reported diffusivity increases or anisotropy decreases in the same set of WM areas (Fellgiebel et al, 2004;Medina et al, 2006;Xie et al, 2006;Huang et al, 2007;Teipel et al, 2007;Zhang et al, 2007). Atrophy of the CC and perforant path have also already been highlighted in previous VBM studies of AD (Chaim et al, 2007) and MCI (Stoub et al, 2006), respectively. That highly consistent patterns of WM atrophy are defined using two highly different methods of acquisition and analysis such as DTI and VBM is noteworthy, and our study further emphasizes the validity and sensitivity of automatic whole-brain VBM to assess WM atrophy in AD.…”

Section: Discussionsupporting

confidence: 90%

Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

Villain¹,

Desgranges²,

Viader³

et al. 2008

Journal of Neuroscience

335

243

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In early Alzheimer's disease (AD), the hippocampal region is the area most severely affected by cellular and structural alterations, yet glucose hypometabolism predominates in the posterior association cortex and posterior cingulate gyrus. One prevalent hypothesis to account for this discrepancy is that posterior cingulate hypometabolism results from disconnection from the hippocampus through disruption of the cingulum bundle. However, only partial and indirect evidence currently supports this hypothesis. Thus, using structural magnetic resonance imaging and 2-[ 18 F]fluoro-2-deoxy-D-glucose positron emission tomography in 18 patients with early AD, we assessed the relationships between hippocampal atrophy, white matter integrity, and gray matter metabolism by means of a whole-brain voxel-based correlative approach. We found that hippocampal atrophy is specifically related to cingulum bundle disruption, which is in turn highly correlated to hypometabolism of the posterior cingulate cortex but also of the middle cingulate gyrus, thalamus, mammillary bodies, parahippocampal gyrus, and hippocampus (all part of Papez's circuit), as well as the right temporoparietal associative cortex. These results provide the first direct evidence supporting the disconnection hypothesis as a major factor contributing to the early posterior hypometabolism in AD. Disruption of the cingulum bundle also appears to relate to hypometabolism in a large connected network over and above the posterior cingulate cortex, encompassing the whole memory circuit of Papez (consistent with the key location of this white matter tract within this loop) and also, but indirectly, the right posterior association cortex.

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Section: Discussionsupporting

confidence: 90%

Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

Villain¹,

Desgranges²,

Viader³

et al. 2008

Journal of Neuroscience

335

243

View full text Add to dashboard Cite

show abstract

“…Thomann et al [10] found a significant loss of callosal volume in the anterior portion of the CC (rostrum, genu, and anterior body). Chaim and colleagues [8] reported a reduction in almost all subregions of the CC (genu, anterior and posterior body, isthmus, splenium), but mainly in the left hemisphere. Li et al [42] found a reduction limited to the posterior CC subregions (isthmus and splenium), and, in agreement with Chaim et al [8], prevalently on the left side of the CC.…”

Section: Voxel-based Morphometry Studiesmentioning

confidence: 99%

“…Many studies included AD patients with different degrees of pathology, for example, from mild to severe [7,14,15] or from mild to moderate [8,10,42] (see Tables 1, 2, 3). Thus, results may have been biased by the presence of subjects at different illness stages.…”

Section: Discrepancies With Previous Findingsmentioning

confidence: 99%

“…The corpus callosum (CC) has been implicated in this process [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. In particular, it has been suggested that callosal atrophy in AD is the anatomical correlate of Wallerian degeneration of commissural nerve fibers.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, the main result mentioned above, that is atrophy mainly in the callosal anterior and posterior subregions, comes from studies of AD groups that included patients in different illness stages, ranging from mild to severe dementia [7,8,[10][11][12][14][15][16][17][18][19][23][24][25][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] and sometimes selected using different diagnostic criteria [10,14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Paola

Spalletta

Caltagirone

2010

JAD

128

103

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Abstract. The corpus callosum (CC), which connects the two cerebral hemispheres, is the largest white matter fiber bundle in the human brain. This structure presents a peculiar myelination pattern: it has small diameter fibers, located in the genu, which myelinate much later in normal development, and large diameter fibers of the splenium, which myelinate early in development. Although the pathology of AD mainly involves the cerebral gray matter structure, there is evidence that white matter may also be involved. To illustrate callosal white matter changes in AD pathology, in this review we summarize in vivo imaging studies in humans, focusing on region of interest, voxel-based morphometry, diffusion-weighted imaging, and diffusion tensor imaging techniques. Our aims were to identify where in the CC, when in the different stages of AD, and how callosal changes can be detected with different MRI techniques. Results showed that changes in the anterior (genu and anterior body) as well as in the posterior (isthmus and splenum) portions of the CC might already be present in the early stages of AD. These findings support the hypothesis that two mechanisms, Wallerian degeneration and myelin breakdown, might be responsible for the region-specific changes detected in AD patients. Wallerian degeneration affects the posterior CC subregion, which receives axons directly from those brain areas (temporo-parietal lobe regions) primarily affected by the AD pathology. Instead, the myelin breakdown process affects the later-myelinating CC subregion and explains the earlier involvement of the genu in CC atrophy.

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Corpus callosum integrity loss predicts cognitive impairment in Leukoaraiosis

Wang

Bai

Liu

et al. 2020

Ann Clin Transl Neurol

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Objective: To investigate regional white matter fibers loss in Leukoaraiosis (LA) and its relationship with cognitive impairments. Methods: Fifty-six participants with LA and 38 healthy controls underwent clinical evaluations and MR scans. Participants with LA were classified as cognitively normal (LA-NC, n = 18), vascular cognitive impairment of none dementia (LA-VCIND, n = 24), and vascular dementia (LA-VaD, n = 14) by Mini-Mental State Examination and Clinical Dementia Rating. Cognitive domains including visual-spatial, naming, attention, language, abstraction, memory, and orientation were assessed. With the use of Tract-based spatial statistics, mean fractional anisotropy (FA) of major white matter fiber tracts were compared between LA and controls and among LA groups with varying levels of cognitive impairments. Regression analyses were performed to evaluate relationships between FA values and cognitive performance. Results: Participants showed significant FA reduction in the corpus callosum (CC), bilateral corona radiata, anterior limb of the internal capsule, external capsule, posterior thalamic radiation, and superior longitudinal fasciculus compared to controls and across LA groups. The LA-VaD group showed consistent damage in the body and genu of CC compared to the LA-NC and LA-VCIND groups. A positive correlation between visualspatial and FA reduction in right anterior corona radiates in LA-VCIND and body of CC in LA-VaD. Interpretation: We found regional fiber loss in the CC across the cognitive spectrum in patients with LA and correlations between FA and visuospatial impairment in the anterior corona radiata in patients with LA-VCIND and in the body of CC in patients with LA-VaD.

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Volumetric reduction of the corpus callosum in Alzheimer's disease in vivo as assessed with voxel-based morphometry

Cited by 74 publications

References 46 publications

Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Corpus callosum integrity loss predicts cognitive impairment in Leukoaraiosis

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