Volumetric oxygen mass transfer coefficient in an upflow cocurrent packed-bed bioreactor

Deront, M.; Samb, Falilou M.; Adler, N.; Péringer, Paul

doi:10.1016/s0009-2509(98)00003-7

Cited by 25 publications

(22 citation statements)

References 25 publications

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“…At the same time, the difference in k L a values between 0.13-m and 0.26-m beds is small (about 20 %). Consequently, the slightly higher values obtained by other authors might be due to variable geometry and largely different measurement techniques [12].…”

Section: Comparison With Results Obtained By Other Authorsmentioning

confidence: 77%

“…8. There are only limited results for the volumetric mass transfer coefficient in fibrous bed bioreactors, so prevailingly, data obtained for granular beds [12,16] were used. In so far as a result reported by Bhatia et al [15] which coincides with the upper range of gas velocity values of this study, it is shown in the figure.…”

Section: Comparison With Results Obtained By Other Authorsmentioning

confidence: 99%

“…There is a significant amount of research on the gas flow regimes, the gas holdup, and the static gas fraction in threephase fixed beds under ambient operating conditions [10][11][12][13][14][15][16]. Mass transfer in biofilter fixed beds has been studied recently by Maldonado et al [16] and before that by Deront et al [12]. Cases of granular beds have been analyzed in order to deter-mine the influence of the solid holdup, gas velocity, and liquid flow rate.…”

Section: Introductionmentioning

confidence: 99%

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Gas‐Liquid Mass Transfer in Fibrous Bed Reactor with Counter‐Current Liquid Recycle

Martinov¹,

Hadjiev²,

Vlaev

2009

Chem Eng & Technol

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In this work, the gas-liquid mass transfer in a lab-scale fibrous bed reactor with liquid recycle was studied. The volumetric gas-liquid mass transfer coefficient, k L a, is determined over a range of the superficial liquid velocity (0.0042-0.0126 m.s ), surface tension (35-72 mN/m), and viscosity (1-6 mPa.s). Increasing fluid velocities and viscosity, and decreasing interfacial tension, the volumetric oxygen transfer coefficient increased. In contrast to the case of co-current flow, the effect of gas superficial velocity was found to be more significant than the liquid superficial velocity. This behavior is explained by variation of the coalescing gas fraction and the reduction in bubble size. A correlation for k L a is proposed. The predicted values deviate within ± 15 % from the experimental values, thus, implying that the equation can be used to predict gas-liquid mass transfer rates in fibrous bed recycle bioreactors.

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Section: Comparison With Results Obtained By Other Authorsmentioning

confidence: 77%

Section: Comparison With Results Obtained By Other Authorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gas‐Liquid Mass Transfer in Fibrous Bed Reactor with Counter‐Current Liquid Recycle

Martinov¹,

Hadjiev²,

Vlaev

2009

Chem Eng & Technol

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“…Local methods involved physical measurement such as photography or conductivity to determine interfacial area of bubbles. Global methods can be divided in two groups: physical and chemical methods [6]. Physical absorption methods (based on gassing-in, gassing-out or pressure step) can be dynamic or steady state.…”

mentioning

confidence: 99%

“…Chemical absorption methods can be classified depending on the reactional rates. The most widely used chemical method is sulphite oxidation [1], but any reaction with oxygen can be used (hydrazine oxidation [10]; CuCl oxidation [6]) in the condition of a reaction rate sufficiently high compared with the OTR. Sometime CO 2 rather than O 2 is used to determined k L a, even if k L a slightly differs for these two gases [2,10].…”

mentioning

confidence: 99%

k L a determination: comparative study for a gas mass balance method

Poughon

Duchez

Cornet

et al. 2003

Bioprocess and Biosystems Engineering

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The determination of k(L) a by a gas balance method coupled with sulphite oxidation is compared for three kinds of processes (stirred tank, bubble column and fixed-bed column reactors) with a gassing-in and with a classical chemical sulphite oxidation method. The mathematical relations required for the determination of the k(L) a value are detailed. In coalescing gas-liquid conditions, the values calculated by the three methods are shown to be comparable. The gas balance method is more rapid than either the steady-state gassing-in or the chemical sulphite reaction rate measurement methods. It is also well adapted for three-phase systems (gas-liquid-solid) in which the non-coalescing effects of sulphite solution are reduced by solid interferences.

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Mass transfer and mixing characteristics in an airlift‐driven fibrous‐bed bioreactor

2010

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An internal loop airlift-driven fibrous bed bioreactor (ILALFBB) was designed and developed with a high degree of flexibility to handle genetically engineered and fragile shear-sensitive cells. The mixing and oxygen mass transfer characteristics have been investigated. A cotton fibre was set in the downcomer of the ILALB to represent the fibrous packed bed and the outcome results were compared with those of the polyurethane foam (PUF) packed and unpacked ILALB systems. The effects of fibre, packing height, bed top and bottom clearances, spacing between adjacent fibre surfaces, and superficial gas velocity were investigated. The liquid phase mixing output variables included the liquid circulation velocity (U Lc ), circulation time (t Lc ), mixing time (t Lm ), Bodenstein number (Bo L ), and axial dispersion coefficient (E L ), whereas the mass transfer out variable was the K L a. Bo L and E L in the riser and downcomer regions of all packed systems increased with increasing in packing height, packing top clearance, and superficial gas velocity, except the overall Bo L was independent of gas velocity at low gas velocities. The Bo L was found highest in the riser of the large cotton and small PUF packed system with large spacing and the E L in the downcomer of PUF packed systems with smaller spacing between fibre surfaces. Increased amounts of packing in the ILALB, whether in the form of cotton or PUF decreased the U Lc in the bioreactor because of the increased frictional resistance and tortuosity. The reduction in U Lc was significant for large packing with smaller spacing between fibre surfaces and increased bottom clearances of the cotton packed system. High circulation times (t Lc ) and shorter mixing times (t Lm ) were achieved using small PUF packing with large top clearance. Relatively high K L a values were obtained using large packing with large top clearances and spacing between fibre surfaces. The boost in K L a was associated with increased gas holdup and/or interfacial area, due to bubble breakage by the shearing action of the fibrous-bed. Empirical correlation proposed for E L , Bo L , and K L a gave a good fit of the experimental data.Un bioréacteurà boucle interne opérant par air-lift età lit fibreux (ILALFBB) aété conçu et développé avec un niveauélevé de flexibilité pour la manipulation des cellules génétiquement modifiées, fragiles et sensibleà l'effet de cisaillement. Les caractéristiques de mélange et de transfert de masse de l'oxygène ontétéétudiées. Les effets de la structure de la garniture de remplissage ontétéétudiés. BoL et E L dans les régions de canalisation montante et de la canalisation descendante de tous les systèmes garnis ont augmenté avec l'accroissement de la hauteur de remplissage, du dégagement supérieur de la garniture de remplissage et de la vitesse superficielle de gaz, sauf que le BoL globalétait indépendant de la vitesse de gazà faible vitesses de gaz. Le BoL le plusélevé aété observé dans la canalisation montante du système constitué de larges garnitures de coton, des pe...

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Volumetric oxygen mass transfer coefficient in an upflow cocurrent packed-bed bioreactor

Cited by 25 publications

References 25 publications

Gas‐Liquid Mass Transfer in Fibrous Bed Reactor with Counter‐Current Liquid Recycle

Gas‐Liquid Mass Transfer in Fibrous Bed Reactor with Counter‐Current Liquid Recycle

k L a determination: comparative study for a gas mass balance method

Mass transfer and mixing characteristics in an airlift‐driven fibrous‐bed bioreactor

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