Volumetric imaging of the tumor microvasculature reflects outcomes and genomic states of clear cell renal cell carcinoma
Yuta Kaneko,
Tsukasa Masuda,
Kimiharu Takamatsu
et al.
Abstract:Tumor structure is heterogeneous and complex, and it is difficult to obtain complete characteristics by two‐dimensional analysis. The aim of this study was to visualize and characterize volumetric vascular information of clear cell renal cell carcinoma (ccRCC) tumors using whole tissue phenotyping and three‐dimensional light‐sheet microscopy. Here, we used the diagnosing immunolabeled paraffin‐embedded cleared organs pipeline for tissue clearing, immunolabeling, and three‐dimensional imaging. The spatial distr… Show more
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